DOI: 10.1002/bies.950180604. BMP‐1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation

BMP‐1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation

10.1002/bies.950180604

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractMembers of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP‐1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF‐β superfamily. Recent finding(1) indicate that BMP‐1 is identical to pro‐collagen C‐proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern formation during development. Taken together, current studies indicate that BMP‐1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes.

Bibliography

Sarras, M. P. (1996). BMPâ1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation. BioEssays, 18(6), 439â442. Portico.

Authors 1

Michael P. Sarras (first)

References 26 Referenced 52

10.1126/science.271.5247.360
10.1073/pnas.76.4.1828
10.1126/science.3201241
10.1016/S0021-9258(18)54648-2 / J. Biol. Chem. / The astacin family of metallopeptidases by Dumermuth E. (1991)
10.1002/pro.5560040701
10.1016/0014-5793(93)80312-I
10.1002/pro.5560040502
10.1016/0076-6879(95)48052-8
10.1016/0092-8674(91)90522-Z
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10.1093/genetics/141.1.271 / Genetics / The tolkin gene is a tolloid/BMP‐1 homologue that is essential for Drosophila development by Finelli A. L. (1995)
10.1242/dev.114.3.583 / Development / Localized enhancement and repression of the activity of the TGF‐beta family member, decapentaplegic, is necessary for dorsal‐ventral pattern formation in the Drosophila embryo by Ferguson E. L. (1992)
10.1006/dbio.1994.1079
10.1242/dev.120.4.861 / Development / Mutational analysis of the Drosophila tolloid gene, a human BMP‐1 homolog by Finelli A. L. (1994)
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10.1016/0092-8674(93)80045-G
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10.1242/dev.114.3.769 / Development / Early mRNAs, spatially restricted along the animal‐vegetal axis of sea urchin embryos, include one encoding a protein related to tolloid and BMP‐1 by Reyolds S. D. (1992)
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10.1016/0076-6879(95)48021-8
10.1242/dev.121.6.1591 / Development / Hydra metalloproteinase 1 (HMP1), a member of the astacin family, localizes to extracellular matirx in a head specific manner and has a functional role during development by Yan L. (1995)
10.1016/0962-8924(92)90057-T
10.1083/jcb.124.1.171
10.1146/annurev.cb.06.110190.003121

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 3:21 a.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 5:05 a.m.)
Indexed	6 days, 13 hours ago (Aug. 30, 2025, 12:27 p.m.)
Issued	29 years, 3 months ago (June 1, 1996)
Published	29 years, 3 months ago (June 1, 1996)
Published Online	20 years, 7 months ago (Feb. 5, 2005)
Published Print	29 years, 3 months ago (June 1, 1996)

Funders 0

None

BibTeX

@article{Sarras_1996, title={BMP‐1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation}, volume={18}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950180604}, DOI={10.1002/bies.950180604}, number={6}, journal={BioEssays}, publisher={Wiley}, author={Sarras, Michael P.}, year={1996}, month=jun, pages={439–442} }

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