DOI: 10.1002/bies.950180505. Hierarchical guidance cues in the developing nervous system of <i>C. elegans</i>

Hierarchical guidance cues in the developing nervous system of C. elegans

10.1002/bies.950180505

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractDuring embryogenesis, the basic axon scaffold of the nervous system is formed by special axons that pioneer pathways between groups of cells. To find their way, the pioneer growth cones detect specific cues in their extracellular environment. One of these guidance cues is netrin. Observations and experimental manipulations in vertebrates and nematodes have shown that netrin is a bifunctional guidance cue that can simultaneously attract and repel axons. During the formation of this basic axon scaffold in Caenorhabditis elegans, the netrin UNC‐6 is expressed by neuroglia and pioneer neurons, providing hierarchical guidance cues throughout the animal. Each cue has a characteristic role depending on the cell type, its position and the developmental stage. These roles include activities as global, decussation and labeled‐pathway cues. This hierarchical model of UNC‐6 netrin‐mediated guidance suggests a method by which guidance cues can direct formation of basic axon scaffolds in developing nervous systems.

Bibliography

Wadsworth, W. G., & Hedgecock, E. M. (1996). Hierarchical guidance cues in the developing nervous system of C. elegans. BioEssays, 18(5), 355â362. Portico.

Authors 2

William G. Wadsworth (first)
Edward M. Hedgecock (additional)

References 48 Referenced 35

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 3:15 a.m.)
Deposited	1 year, 10 months ago (Oct. 27, 2023, 9:35 a.m.)
Indexed	3 months, 3 weeks ago (May 12, 2025, 4:27 p.m.)
Issued	29 years, 4 months ago (May 1, 1996)
Published	29 years, 4 months ago (May 1, 1996)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	29 years, 4 months ago (May 1, 1996)

Funders 0

None

BibTeX

@article{Wadsworth_1996, title={Hierarchical guidance cues in the developing nervous system of C. elegans}, volume={18}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950180505}, DOI={10.1002/bies.950180505}, number={5}, journal={BioEssays}, publisher={Wiley}, author={Wadsworth, William G. and Hedgecock, Edward M.}, year={1996}, month=may, pages={355–362} }

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