DOI: 10.1002/bies.950160104. Convergence and divergence in the evolution of transport proteins

Convergence and divergence in the evolution of transport proteins

10.1002/bies.950160104

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractDifferent families of transport proteins catalyze transmembrane solute translocation, employing different mechanisms and energy sources. Several of these functionally dissimilar proteins nevertheless exhibit similar strutural units, consisting of six tightly packed α‐helices which may comprise all or part of a transmembrane channel. It is now recognized that some of these families arose independently of each other by convergence, while others arose from common precursors by divergence. The former families apparently arose at different times in evolutionary history, in different groups of organisms, employing different routes.

Bibliography

Saier, M. H. (1994). Convergence and divergence in the evolution of transport proteins. BioEssays, 16(1), 23â29. Portico.

Authors 1

Milton H. Saier (first)

References 56 Referenced 25

10.1111/j.1095-8312.1999.tb01918.x
10.1016/0923-2508(90)90001-7
10.1002/bies.950141106
{'key': 'e_1_2_1_5_2', 'volume-title': 'The Structure of Biological Membranes', 'author': 'Yeagle P.', 'year': '1992'} / The Structure of Biological Membranes by Yeagle P. (1992)
10.3109/10409239309086795
10.1016/0968-0004(93)90081-W
10.3109/10409239309086796
Fagan M. J.andSaier M. H. Jr.(1994). P‐type ATPases of eukaryotes and bacteria: Sequence comparisons and construction of phylogenetic trees.J. Mol. Evol. in press. (10.1007/BF00175496)
10.1016/0959-440X(91)90034-Q
10.1126/science.1279804
10.1111/j.1365-2958.1991.tb02145.x
10.1111/j.1365-2958.1992.tb01487.x
10.1016/0014-5793(91)80336-2
10.1038/358727a0
{'key': 'e_1_2_1_16_2', 'volume-title': 'Ionic Channels of Excitable Membranes', 'author': 'Hille B.', 'year': '1992'} / Ionic Channels of Excitable Membranes by Hille B. (1992)
10.1146/annurev.bb.22.060193.001133
10.1006/jmbi.1993.1107
10.1096/fasebj.4.9.1693348
10.1146/annurev.bb.20.060191.000433
10.1083/jcb.118.2.481
10.1016/S0021-9258(19)36953-4
10.1016/B978-0-444-89871-5.50027-4
10.1111/j.1365-2958.1991.tb01823.x
10.1016/S0021-9258(19)38941-0 / J. Biol. Chem. / Hydrodnamic characterization of the major intrinsic protein from the bovine lens fiber membranes by Aerts T. (1990)
10.1016/0955-0674(92)90090-Y
10.1016/S0021-9258(19)37116-9 / J. Biol. Chem. / Membrane topology of the pBR322 tetracycline resistance protein. TetA‐PhoA gene fusions and implications for the mechanism of TetA membrane insertion by Allard J. D. (1992)
10.1128/jb.175.2.565-567.1993
10.1002/pro.5560020103
Reizer J. Reizer A.andSaier M. H. Jr.(1994). A functional superfamily of sodium:solute symporters.Biochim. Biophys. Acta.in press. (10.1016/0304-4157(94)90003-5)
10.1016/0014-5793(92)80905-V
10.1016/0968-0004(90)90194-G
{'key': 'e_1_2_1_33_2', 'volume-title': 'The Evolution of Metabolic Function', 'author': 'Mortlock R. P.', 'year': '1992'} / The Evolution of Metabolic Function by Mortlock R. P. (1992)
10.1128/jb.174.5.1433-1438.1992
10.1111/j.1365-2958.1990.tb00698.x
10.1073/pnas.88.21.9603
10.1016/S0021-9258(19)50243-5
10.1146/annurev.cb.08.110192.000435
10.1002/pro.5560011012
10.1016/0300-9084(90)90063-M
10.1128/mr.57.2.320-346.1993 / Microbiol. Rev. / Structural, functional and evolutionary relation‐ships among the extracellular solute‐binding receptors of bacteria by Tam R. (1993)
10.1006/jmbi.1993.1543
Fath M. J.andKolter R.(1993). ABC‐transporters: The bacterial exporters.Microbiol. Rev. in press. (10.1128/mr.57.4.995-1017.1993)
10.1016/0896-6273(90)90212-X
10.1016/0896-6273(93)90269-W
10.1016/S0021-9258(18)45882-6 / J. Biol. Chem. / Topology of the hydrophobic membrane‐bound components of the histidine periplasmic permease. Comparison with other members of the family by Kerppola R. E. (1992)
10.1111/j.1365-2958.1993.tb01094.x
10.1016/0923-2508(90)90008-E
10.1111/j.1365-2958.1993.tb01607.x
10.1016/0147-619X(92)90004-T
10.1128/jb.174.9.3092-3094.1992
10.1016/S0021-9258(18)42315-0
10.1016/S0021-9258(18)41771-1
10.1128/jb.175.2.351-357.1993
10.1111/j.1749-6632.1992.tb43801.x
10.1128/jb.175.11.3480-3485.1993
10.1073/pnas.87.4.1456

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 5:11 a.m.)
Deposited	1 year, 10 months ago (Oct. 24, 2023, 10:10 a.m.)
Indexed	3 weeks, 2 days ago (Aug. 5, 2025, 8:35 a.m.)
Issued	31 years, 7 months ago (Jan. 1, 1994)
Published	31 years, 7 months ago (Jan. 1, 1994)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	31 years, 7 months ago (Jan. 1, 1994)

Funders 0

None

BibTeX

@article{Saier_1994, title={Convergence and divergence in the evolution of transport proteins}, volume={16}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950160104}, DOI={10.1002/bies.950160104}, number={1}, journal={BioEssays}, publisher={Wiley}, author={Saier, Milton H.}, year={1994}, month=jan, pages={23–29} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        5
      ]
    ],
    "date-time": "2025-08-05T12:35:21Z",
    "timestamp": 1754397321612
  },
  "reference-count": 56,
  "publisher": "Wiley",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            2,
            5
          ]
        ],
        "date-time": "2005-02-05T00:00:00Z",
        "timestamp": 1107561600000
      },
      "content-version": "vor",
      "delay-in-days": 4053,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [
      "onlinelibrary.wiley.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        1
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Different families of transport proteins catalyze transmembrane solute translocation, employing different mechanisms and energy sources. Several of these functionally dissimilar proteins nevertheless exhibit similar strutural units, consisting of six tightly packed \u03b1\u2010helices which may comprise all or part of a transmembrane channel. It is now recognized that some of these families arose independently of each other by convergence, while others arose from common precursors by divergence. The former families apparently arose at different times in evolutionary history, in different groups of organisms, employing different routes.</jats:p>",
  "DOI": "10.1002/bies.950160104",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        2,
        25
      ]
    ],
    "date-time": "2005-02-25T10:11:16Z",
    "timestamp": 1109326276000
  },
  "page": "23-29",
  "update-policy": "http://dx.doi.org/10.1002/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 25,
  "title": "Convergence and divergence in the evolution of transport proteins",
  "prefix": "10.1002",
  "volume": "16",
  "author": [
    {
      "suffix": "Jr",
      "given": "Milton H.",
      "family": "Saier",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2005,
        2,
        5
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1095-8312.1999.tb01918.x"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0923-2508(90)90001-7"
    },
    {
      "key": "e_1_2_1_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bies.950141106"
    },
    {
      "key": "e_1_2_1_5_2",
      "volume-title": "The Structure of Biological Membranes",
      "author": "Yeagle P.",
      "year": "1992"
    },
    {
      "key": "e_1_2_1_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.3109/10409239309086795"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0968-0004(93)90081-W"
    },
    {
      "key": "e_1_2_1_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.3109/10409239309086796"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "crossref",
      "unstructured": "Fagan M. J.andSaier M. H. Jr.(1994). P\u2010type ATPases of eukaryotes and bacteria: Sequence comparisons and construction of phylogenetic trees.J. Mol. Evol. in press.",
      "DOI": "10.1007/BF00175496"
    },
    {
      "key": "e_1_2_1_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0959-440X(91)90034-Q"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1279804"
    },
    {
      "key": "e_1_2_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1991.tb02145.x"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1992.tb01487.x"
    },
    {
      "key": "e_1_2_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(91)80336-2"
    },
    {
      "key": "e_1_2_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/358727a0"
    },
    {
      "key": "e_1_2_1_16_2",
      "volume-title": "Ionic Channels of Excitable Membranes",
      "author": "Hille B.",
      "year": "1992"
    },
    {
      "key": "e_1_2_1_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bb.22.060193.001133"
    },
    {
      "key": "e_1_2_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.1993.1107"
    },
    {
      "key": "e_1_2_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fasebj.4.9.1693348"
    },
    {
      "key": "e_1_2_1_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bb.20.060191.000433"
    },
    {
      "key": "e_1_2_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.118.2.481"
    },
    {
      "key": "e_1_2_1_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)36953-4"
    },
    {
      "key": "e_1_2_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/B978-0-444-89871-5.50027-4"
    },
    {
      "key": "e_1_2_1_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1991.tb01823.x"
    },
    {
      "key": "e_1_2_1_25_2",
      "doi-asserted-by": "crossref",
      "first-page": "8675",
      "DOI": "10.1016/S0021-9258(19)38941-0",
      "article-title": "Hydrodnamic characterization of the major intrinsic protein from the bovine lens fiber membranes",
      "volume": "265",
      "author": "Aerts T.",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "e_1_2_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0955-0674(92)90090-Y"
    },
    {
      "key": "e_1_2_1_27_2",
      "doi-asserted-by": "crossref",
      "first-page": "17809",
      "DOI": "10.1016/S0021-9258(19)37116-9",
      "article-title": "Membrane topology of the pBR322 tetracycline resistance protein. TetA\u2010PhoA gene fusions and implications for the mechanism of TetA membrane insertion",
      "volume": "267",
      "author": "Allard J. D.",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "e_1_2_1_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.175.2.565-567.1993"
    },
    {
      "key": "e_1_2_1_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/pro.5560020103"
    },
    {
      "key": "e_1_2_1_30_2",
      "doi-asserted-by": "crossref",
      "unstructured": "Reizer J. Reizer A.andSaier M. H. Jr.(1994). A functional superfamily of sodium:solute symporters.Biochim. Biophys. Acta.in press.",
      "DOI": "10.1016/0304-4157(94)90003-5"
    },
    {
      "key": "e_1_2_1_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(92)80905-V"
    },
    {
      "key": "e_1_2_1_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0968-0004(90)90194-G"
    },
    {
      "key": "e_1_2_1_33_2",
      "volume-title": "The Evolution of Metabolic Function",
      "author": "Mortlock R. P.",
      "year": "1992"
    },
    {
      "key": "e_1_2_1_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.174.5.1433-1438.1992"
    },
    {
      "key": "e_1_2_1_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1990.tb00698.x"
    },
    {
      "key": "e_1_2_1_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.21.9603"
    },
    {
      "key": "e_1_2_1_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(19)50243-5"
    },
    {
      "key": "e_1_2_1_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cb.08.110192.000435"
    },
    {
      "key": "e_1_2_1_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/pro.5560011012"
    },
    {
      "key": "e_1_2_1_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0300-9084(90)90063-M"
    },
    {
      "key": "e_1_2_1_41_2",
      "doi-asserted-by": "crossref",
      "first-page": "320",
      "DOI": "10.1128/mr.57.2.320-346.1993",
      "article-title": "Structural, functional and evolutionary relation\u2010ships among the extracellular solute\u2010binding receptors of bacteria",
      "volume": "57",
      "author": "Tam R.",
      "year": "1993",
      "journal-title": "Microbiol. Rev."
    },
    {
      "key": "e_1_2_1_42_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.1993.1543"
    },
    {
      "key": "e_1_2_1_43_2",
      "doi-asserted-by": "crossref",
      "unstructured": "Fath M. J.andKolter R.(1993). ABC\u2010transporters: The bacterial exporters.Microbiol. Rev. in press.",
      "DOI": "10.1128/mr.57.4.995-1017.1993"
    },
    {
      "key": "e_1_2_1_44_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(90)90212-X"
    },
    {
      "key": "e_1_2_1_45_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0896-6273(93)90269-W"
    },
    {
      "key": "e_1_2_1_46_2",
      "doi-asserted-by": "crossref",
      "first-page": "2329",
      "DOI": "10.1016/S0021-9258(18)45882-6",
      "article-title": "Topology of the hydrophobic membrane\u2010bound components of the histidine periplasmic permease. Comparison with other members of the family",
      "volume": "267",
      "author": "Kerppola R. E.",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "e_1_2_1_47_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1993.tb01094.x"
    },
    {
      "key": "e_1_2_1_48_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0923-2508(90)90008-E"
    },
    {
      "key": "e_1_2_1_49_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1365-2958.1993.tb01607.x"
    },
    {
      "key": "e_1_2_1_50_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0147-619X(92)90004-T"
    },
    {
      "key": "e_1_2_1_51_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.174.9.3092-3094.1992"
    },
    {
      "key": "e_1_2_1_52_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)42315-0"
    },
    {
      "key": "e_1_2_1_53_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0021-9258(18)41771-1"
    },
    {
      "key": "e_1_2_1_54_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.175.2.351-357.1993"
    },
    {
      "key": "e_1_2_1_55_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1749-6632.1992.tb43801.x"
    },
    {
      "key": "e_1_2_1_56_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.175.11.3480-3485.1993"
    },
    {
      "key": "e_1_2_1_57_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.4.1456"
    }
  ],
  "container-title": "BioEssays",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbies.950160104",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.950160104",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        24
      ]
    ],
    "date-time": "2023-10-24T14:10:24Z",
    "timestamp": 1698156624000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/bies.950160104"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        1
      ]
    ]
  },
  "references-count": 56,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1994,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/bies.950160104"
  ],
  "URL": "http://dx.doi.org/10.1002/bies.950160104",
  "relation": {},
  "ISSN": [
    "0265-9247",
    "1521-1878"
  ],
  "subject": [],
  "container-title-short": "BioEssays",
  "published": {
    "date-parts": [
      [
        1994,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "1993-09-27",
      "order": 1,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2005-02-05",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}