DOI: 10.1002/bies.950150305. The assembly of signalling complexes by receptor tyrosine kinases

The assembly of signalling complexes by receptor tyrosine kinases

10.1002/bies.950150305

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractCell proliferation in response to growth factors is mediated by specific high affinity receptors. Ligand‐binding by receptors of the protein tyrosine kinase family results in the stimulation of several intracellular signal transduction pathways. Key signalling enzymes are recruited to the plasma membrane through the formation of stable complexes with activated receptors. These interactions are mediated by the conserved, non‐catalytic SH2 domains present in the signalling molecules, which bind with high affinity and specificity to tyrosine‐phosphorylated sequences on the receptors. The assembly of enzyme complexes is emerging as a major mechanism of signal transduction and may regulate the pleiotropic effects of growth factors.

Bibliography

Panayotou, G., & Waterfield, M. D. (1993). The assembly of signalling complexes by receptor tyrosine kinases. BioEssays, 15(3), 171â177. Portico.

Authors 2

George Panayotou (first)
Michael D. Waterfield (additional)

References 78 Referenced 103

10.1126/science.1659742
10.1038/304035a0
10.1038/307521a0
10.1002/j.1460-2075.1988.tb03044.x
10.1016/0092-8674(90)90801-K
10.1016/0959-440X(91)90035-R
10.1038/339155a0
10.1038/339230a0
10.1128/MCB.10.8.4035
10.1126/science.3018928
10.1038/332644a0
10.1038/351033a0
10.1016/0092-8674(91)90411-Q
10.1016/0092-8674(91)90410-Z
10.1016/0092-8674(91)90409-R
10.1016/0092-8674(92)90166-A
10.1016/0092-8674(87)90168-1
10.1016/0092-8674(89)90182-7
10.1126/science.2466336 / Science / Role of phosphatidylinositol kinase in PDGF receptor signal transduction by Coughlin S. R. (1989)
10.1002/j.1460-2075.1990.tb07527.x
10.1002/j.1460-2075.1992.tb05182.x
10.1016/0092-8674(92)90444-H
10.1002/j.1460-2075.1992.tb05426.x
10.1038/342699a0
10.1002/j.1460-2075.1990.tb07417.x
10.1002/j.1460-2075.1992.tb05181.x
10.1016/0092-8674(89)90869-6
10.1016/0092-8674(91)90639-G
10.1073/pnas.87.10.3816
10.1126/science.2541501
10.1128/MCB.9.7.2934
10.1016/0092-8674(89)90048-2
10.1016/0092-8674(89)90047-0
10.1073/pnas.86.21.8232
10.1128/MCB.10.2.435
10.1128/MCB.12.1.128
10.1002/j.1460-2075.1992.tb05087.x
10.1128/MCB.11.10.5068
10.1016/0092-8674(90)90054-I
10.1038/342711a0
10.1016/0092-8674(90)90220-9
10.1126/science.2157284
10.1128/MCB.12.6.2534
10.1128/MCB.10.11.5601
10.1038/343377a0
10.1002/j.1460-2075.1990.tb07887.x
10.1021/bi00143a001
10.1016/0092-8674(92)90167-B
10.1016/0092-8674(90)90013-5
10.1016/0092-8674(91)90228-Q
10.1073/pnas.85.23.8855
10.1016/0092-8674(89)90100-1
10.1128/MCB.11.2.913
10.1002/j.1460-2075.1990.tb07576.x
10.1126/science.1708916
10.1016/0959-440X(92)90235-Y
{'key': 'e_1_2_1_58_2', 'first-page': '73', 'article-title': 'Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway', 'volume': '3', 'author': 'Margolis B.', 'year': '1992', 'journal-title': 'Cell Growth & Diff.'} / Cell Growth & Diff. / Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway by Margolis B. (1992)
10.1126/science.2173144
10.1128/MCB.12.3.981
10.1128/MCB.12.3.991
10.1128/MCB.12.8.3415
10.1038/358646a0
10.1038/358684a0
10.1016/0092-8674(92)90437-H
10.1128/MCB.12.2.609
10.1128/MCB.11.2.1107
10.1002/bies.950130303
10.1126/science.1700866
10.1016/0092-8674(91)90461-7
10.1126/science.1848725
10.1002/j.1460-2075.1992.tb05524.x
10.1128/MCB.11.7.3780
10.1126/science.2163545
10.1038/358678a0
10.1038/358681a0
10.1016/S0021-9258(19)39361-5 / J. Biol. Chem. / Human platelets from 3‐phosphorylated phosphoinositides in response to a‐thrombin, U46619, or GTPγS by Kucera G. L. (1990)
10.1038/334353a0
10.1128/MCB.10.12.6742

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 4:20 a.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 2:21 a.m.)
Indexed	2 months ago (June 26, 2025, 2:24 p.m.)
Issued	32 years, 5 months ago (March 1, 1993)
Published	32 years, 5 months ago (March 1, 1993)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	32 years, 5 months ago (March 1, 1993)

Funders 0

None

BibTeX

@article{Panayotou_1993, title={The assembly of signalling complexes by receptor tyrosine kinases}, volume={15}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950150305}, DOI={10.1002/bies.950150305}, number={3}, journal={BioEssays}, publisher={Wiley}, author={Panayotou, George and Waterfield, Michael D.}, year={1993}, month=mar, pages={171–177} }

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