Crossref
journal-article
Wiley
BioEssays (311)
Abstract
AbstractEukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.
References
58
Referenced
202
10.1038/newbio239197a0
/ Nature New Biology / Origin of concatameric T4 DNA by Watson J. D. (1972)10.1016/0022-5193(73)90198-7
10.1146/annurev.bi.53.070184.001115
10.1146/annurev.ge.23.120189.003051
{'key': 'e_1_2_1_6_2', 'first-page': '181', 'article-title': 'The remaking of chromosomes', 'volume': '13', 'author': 'Muller H. J.', 'year': '1938', 'journal-title': 'The Collecting Net – Woods Hole'}
/ The Collecting Net – Woods Hole / The remaking of chromosomes by Muller H. J. (1938)10.1093/genetics/26.2.234
10.1073/pnas.78.10.6354
10.1093/genetics/106.2.207
/ Genetics / Healing of broken linear dicentric chromosomes in yeast by Haber J. E. (1984)10.1016/0022-2836(78)90294-2
10.1016/0378-1119(80)90150-X
10.1073/pnas.78.5.3015
10.1016/0092-8674(82)90109-X
10.1038/310154a0
10.1093/nar/15.22.9143
10.1016/0092-8674(88)90494-1
10.1038/338771a0
10.1038/338774a0
10.1128/MCB.9.1.345
10.1016/0092-8674(87)90577-0
10.1101/SQB.1983.047.01.135
10.1016/0092-8674(89)90610-7
10.1021/bi00455a020
10.1093/nar/15.21.8877
10.1038/342825a0
10.1016/0092-8674(89)90112-8
10.1002/j.1460-2075.1988.tb02916.x
10.1073/pnas.87.5.1758
10.1016/0092-8674(84)90205-8
10.1128/MCB.8.1.251
10.1128/MCB.7.12.4424
10.1016/0092-8674(88)90142-0
10.1073/pnas.81.5.1475
10.1038/303592a0
10.1016/0092-8674(87)90501-0
10.1038/337429a0
10.1038/345456a0
10.1128/MCB.8.11.4642
10.1073/pnas.85.2.534
10.1139/g89-104
10.1016/0092-8674(85)90170-9
10.1016/0092-8674(87)90576-9
10.1093/nar/16.14.6953
10.1128/MCB.9.6.2761
10.1016/0092-8674(89)90035-4
10.1038/337331a0
10.1126/science.1689074
10.1038/344126a0
10.1016/0092-8674(90)90653-V
10.1016/0014-4827(61)90192-6
10.1016/0047-6374(82)90056-2
{'key': 'e_1_2_1_52_2', 'first-page': '518', 'article-title': 'Structure and variability of human chromosome ends', 'volume': '10', 'author': 'De‐Lange T.', 'year': '1990', 'journal-title': 'Molec. Cell Biol.'}
/ Molec. Cell Biol. / Structure and variability of human chromosome ends by De‐Lange T. (1990)10.1038/345458a0
10.1101/SQB.1986.051.01.026
10.1093/nar/17.12.4611
10.1073/pnas.85.23.9086
{'key': 'e_1_2_1_57_2', 'first-page': '465', 'article-title': 'Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos', 'volume': '28', 'author': 'Benn P. A.', 'year': '1976', 'journal-title': 'Am. J. Hum. Genet.'}
/ Am. J. Hum. Genet. / Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos by Benn P. A. (1976)-
Hastie N. D. Dempster M. Dunlop M. G. Thompson D. K.andAllshire R. C.(1990). Telomere reduction in colorectal carcinoma and in association with aging in humans.Naturein press.
(
10.1038/346866a0
) 10.1016/0092-8674(90)90478-W
Dates
Type | When |
---|---|
Created | 20 years, 6 months ago (Feb. 25, 2005, 6:22 a.m.) |
Deposited | 1 year, 10 months ago (Oct. 22, 2023, 1:27 p.m.) |
Indexed | 2 months, 3 weeks ago (June 7, 2025, 12:28 a.m.) |
Issued | 35 years ago (Aug. 1, 1990) |
Published | 35 years ago (Aug. 1, 1990) |
Published Online | 20 years, 6 months ago (Feb. 5, 2005) |
Published Print | 35 years ago (Aug. 1, 1990) |