DOI: 10.1002/bies.950100608. Estrogens, antiestrogens and cell proliferation

Estrogens, antiestrogens and cell proliferation

10.1002/bies.950100608

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractThe classical estrogen receptor model does not sufficiently account for the tumor‐promoting activity of extrogens or for the antiproliferative effect of antiestrogens in estrogen‐dependent tumors. Particular difficulties not readily accommodated within the model are that hormonal autonomy can supervene without loss of the estrogen receptor and that antiestrogen effects are highly context‐dependent, without apparent differences in the estrogen receptor itself or in metabolic transformation of antiestrogens. Recent studies suggest that estrogens may promote cell proliferation, in part, through the mediation of growth factors and that antiestrogens may exert some of their effects by mechanisms unrelated to the estrogen receptor.

Bibliography

Kon, O. L. (1989). Estrogens, antiestrogens and cell proliferation. BioEssays, 10(6), 210â214. Portico.

Authors 1

Oi Lian Kon (first)

References 30 Referenced 19

{'key': 'e_1_2_1_2_2', 'first-page': '245', 'article-title': 'Biochemical pharmacology of antiestrogen action', 'volume': '36', 'author': 'Jordan V. C.', 'year': '1984', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. / Biochemical pharmacology of antiestrogen action by Jordan V. C. (1984)
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{'key': 'e_1_2_1_12_2', 'first-page': '3617', 'article-title': 'Antiproliferative effect of verapamil alone on brain tumor cells. in vitor', 'volume': '48', 'author': 'Schmidt W. F.', 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Antiproliferative effect of verapamil alone on brain tumor cells. in vitor by Schmidt W. F. (1988)
{'key': 'e_1_2_1_13_2', 'first-page': '70', 'article-title': 'Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line', 'volume': '47', 'author': 'Greenberg D. A.', 'year': '1987', 'journal-title': 'Cancer Res.'} / Cancer Res. / Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line by Greenberg D. A. (1987)
{'key': 'e_1_2_1_14_2', 'first-page': '1243', 'article-title': 'Triphenylethylenes: a new class of protein kinase C inhibitors', 'volume': '76', 'author': "O'Brian C. A.", 'year': '1986', 'journal-title': 'J. Natl. Cancer Inst.'} / J. Natl. Cancer Inst. / Triphenylethylenes: a new class of protein kinase C inhibitors by O'Brian C. A. (1986)
{'key': 'e_1_2_1_15_2', 'first-page': '3626', 'article-title': 'Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue', 'volume': '48', 'author': "O'Brian C. A.", 'year': '1988', 'journal-title': 'Cancer Res.'} / Cancer Res. / Specific and direct binding of protein kinase C to an immobilized tamoxifen analogue by O'Brian C. A. (1988)
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{'key': 'e_1_2_1_25_2', 'first-page': '4260', 'article-title': 'Modulation of epidermal growth factor receptor gene expression by transforming growth factor‐beta in a human breast carcinoma cell line', 'volume': '47', 'author': 'Fernandez‐Pol J. A.', 'year': '1987', 'journal-title': 'Cancer Res.'} / Cancer Res. / Modulation of epidermal growth factor receptor gene expression by transforming growth factor‐beta in a human breast carcinoma cell line by Fernandez‐Pol J. A. (1987)
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10.1016/0092-8674(86)90280-1

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 6:09 a.m.)
Deposited	1 year, 10 months ago (Oct. 22, 2023, 3:54 a.m.)
Indexed	4 months ago (April 22, 2025, 3:13 a.m.)
Issued	36 years, 2 months ago (June 1, 1989)
Published	36 years, 2 months ago (June 1, 1989)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	36 years, 2 months ago (June 1, 1989)

Funders 0

None

BibTeX

@article{Kon_1989, title={Estrogens, antiestrogens and cell proliferation}, volume={10}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950100608}, DOI={10.1002/bies.950100608}, number={6}, journal={BioEssays}, publisher={Wiley}, author={Kon, Oi Lian}, year={1989}, month=jun, pages={210–214} }

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