DOI: 10.1002/bies.950070409. Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein

Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein

10.1002/bies.950070409

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractReceptor‐mediated stimulation induces massive actin polymerization and cyto‐skeletal reorganization. The activity of a potent actin‐modulating protein, gelsolin, is regulated both by Ca2+ and polyphos‐phoinositides, and it may have a pivotal role in restructuring the actin cytoskeleton in response to agonist stimulation. Structure‐function analysis of gelsolin has (1) indicated that its NH2‐terminal half is primarily responsible for modulating actin filament length and polymerization; and (2) elucidated mechanisms by which Ca2+ and phospholipids may regulate such functions. Gelsolin is functionally and structurally similar to villin, another Ca2+‐activated actin‐severing protein found in microvilli, suggesting that gelsolin may be a prototype of this family of actin‐modulating proteins. A molecular variant of gelsolin is secreted and may be involved in the clearance of actin filaments released during tissue damage. The two forms of gelsolin are encoded by a single gene, and distinct messages are derived by alternative message splicing.

Bibliography

Yin, H. L. (1987). Gelsolin: Calciumâ and polyphosphoinositideâregulated actinâ modulating protein. BioEssays, 7(4), 176â179. Portico.

Authors 1

H. L. Yin (first)

References 27 Referenced 177

10.1146/annurev.cb.01.110185.002033
10.1146/annurev.bi.55.070186.005011
10.1016/S0021-9258(17)42816-X / J. Biol. Chem. / Actin‐gelsolin interactions: evidence for two actin‐binding sites by Bryan J. (1984)
10.1021/bi00335a046
10.1111/j.1432-1033.1986.tb10126.x
10.1021/bi00344a047
{'key': 'e_1_2_1_8_2', 'first-page': '15033', 'article-title': 'Interaction of plasma gelsolin with G‐actin and F‐actin in the presence and absence of calcium ions', 'volume': '260', 'author': 'Coue M.', 'year': '1985', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. / Interaction of plasma gelsolin with G‐actin and F‐actin in the presence and absence of calcium ions by Coue M. (1985)
10.1016/0006-291X(86)90878-8
10.1083/jcb.102.4.1459
10.1007/BF01753583
10.1084/jem.165.1.97
Lind S. E. Janmey P. A. Chaponnier C. Herbert T. J.&Stossel T. P.(1987). Reversible binding of action to gelsolin and profilin in human platelets.J. Cell Biol.(in press). (10.1083/jcb.105.2.833)
10.1038/325362a0 / Nature / Modulation of gelsolin function by phosphatidylinositol‐4,5‐bis‐phosphate by Janmey P. A. (1987)
Janmey P. A. Kazuko I. Yin H. L.Stossel T. P.(1987). Polyphosphomositide micelles and polyphos‐phoinositide‐containing vesicles dissociate endogenous gelsolin‐actin complexes and promote actin assembly from the fast‐growing end of actin filaments blocked by gelsolin.J. Biol. Chem.(In press.) (10.1016/S0021-9258(18)45341-0)
10.1038/314472a0
Smith D. B. Janmey P. A. Herbert T. J. &Lind S. E.(1987) Quantitative measurement of plasma gelsolin and its incorporation into fibrin clots.J. Lab. Clin. Med.(in press).
10.1016/S0021-9258(18)95726-1 / J. Biol. Chem. / Isolation and properties of two actin‐binding domains in gelsolin by Kwiatkowski D. J. (1985)
{'key': 'e_1_2_1_19_2', 'first-page': '9294', 'article-title': 'Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin', 'volume': '259', 'author': 'Yin H. L.', 'year': '1985', 'journal-title': 'J. Cell. Biol.'} / J. Cell. Biol. / Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin by Yin H. L. (1985)
Kwiatkowski D. J. Mehl R.&Yin H. L.(1987). Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin.J. Cell Biol.(submitted). (10.1083/jcb.106.2.375)
10.1016/S0021-9258(18)61205-0
10.1083/jcb.101.4.1236
10.1083/jcb.103.4.1473
10.1021/bi00361a018
Yin H. L. Iida K.&Janmey P. A.(1986).Identification of a polyphosphoinositide‐regulated domain which mediates binding of gelsolin to the side of actin filaments prior to severing. Manuscript in preparation.
10.1038/323455a0
10.1111/j.1432-1033.1987.tb10997.x
10.1038/315248a0

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 6:38 a.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 8:13 a.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 2:46 p.m.)
Issued	37 years, 10 months ago (Oct. 1, 1987)
Published	37 years, 10 months ago (Oct. 1, 1987)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	37 years, 10 months ago (Oct. 1, 1987)

Funders 0

None

BibTeX

@article{Yin_1987, title={Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein}, volume={7}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950070409}, DOI={10.1002/bies.950070409}, number={4}, journal={BioEssays}, publisher={Wiley}, author={Yin, H. L.}, year={1987}, month=oct, pages={176–179} }

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