Abstract
AbstractIn vertebrate and invertebrate nonmuscle myosins, light‐ and heavy‐chain phosphorylation regulate myosin assembly into filaments, and interaction with actin. Vertebrate non‐muscle myosins can exist in vitro in three main states, either ‘folded’ (assembly‐blocked) or ‘extended’ (assembly‐competent) monomers, and filaments. Light‐chain phosphorylation regulates the ‘dynamic equilibrium’ between these states. The ability of the myosin to undergo changes in conformation and state of assembly may be an important mechanism in regulating the organization of the cytoskeleton and cell motility.
References
29
Referenced
61
10.1146/annurev.bi.46.070177.004053
10.1146/annurev.bi.53.070184.000343
10.1007/BF00711965
10.1073/pnas.75.2.588
10.1038/314321a0
10.1083/jcb.71.3.848
10.1038/314194a0
10.1038/302436a0
10.1016/0022-2836(86)90161-0
10.1146/annurev.bi.49.070180.004421
10.1016/S0006-3495(86)83622-0
10.1016/0092-8674(87)90704-5
10.1016/S0021-9258(18)34755-0
/ J. Biol. Chem. / Localization of the three phosphorylation sites on each heavy chain of Acanthamoeba myosin II to a segment at the end of the tail by Collins J. H. (1982)10.1002/j.1460-2075.1984.tb02289.x
10.1016/S0091-679X(08)61431-4
10.1073/pnas.77.12.7292
10.1083/jcb.104.5.1309
10.1111/j.1432-1033.1986.tb09747.x
10.1016/0014-5793(87)81576-4
10.1126/science.3026049
10.1007/978-3-642-70070-5_9
10.1016/0076-6879(86)34109-0
10.1083/jcb.103.4.1527
10.1038/308864a0
10.1111/j.1432-1033.1987.tb11444.x
10.1083/jcb.74.1.251
10.1016/0076-6879(86)34118-1
10.1038/322080a0
10.1073/pnas.83.24.9433
Dates
Type | When |
---|---|
Created | 20 years, 6 months ago (Feb. 25, 2005, 6:38 a.m.) |
Deposited | 1 year, 10 months ago (Oct. 21, 2023, 8:12 a.m.) |
Indexed | 5 months, 1 week ago (March 24, 2025, 2:45 a.m.) |
Issued | 37 years, 11 months ago (Oct. 1, 1987) |
Published | 37 years, 11 months ago (Oct. 1, 1987) |
Published Online | 20 years, 6 months ago (Feb. 5, 2005) |
Published Print | 37 years, 11 months ago (Oct. 1, 1987) |
@article{Citi_1987, title={Regulation of non‐muscle myosin structure and function}, volume={7}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950070404}, DOI={10.1002/bies.950070404}, number={4}, journal={BioEssays}, publisher={Wiley}, author={Citi, Sandra and Kendrick‐Jones, John}, year={1987}, month=oct, pages={155–159} }