DOI: 10.1002/bies.950050108. Spectrin subtypes in mammalian brain

10.1002/bies.950050108

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractMammalian neural cells contain at least two forms of brain spectrin: brain spectrin (240/235) which is located primarily in the axons and presynaptic terminals of neurons, and brain spectrin (240/235E) which is found in the cell bodies, dendrites and postsynaptic terminals of neurones. Brain spectrin (240/235E) is also found in certain glial cell types. Antibodies against red blood cell spectrin detect only brain spectrin (240/235E), while antibodies against brain spectrin isolated from axonal and synaptic membranes detect brain spectrin (240/235). Previous apparent discrepancies in the literature concerning brain spectrin localization at the light microscope level were undoubtedly due to different laboratories detecting distinct brain spectrin subtypes, based on the particular antibody being utilized for immunohistochemistry. In this review we (1) discuss the data supporting the presence of at least two distinct subtypes of mammalian brain spectrin, (2) explain how these results reconcile previous discrepancies concerning the localization of spectrin within neural cells, and (3) suggest the future implications of these findings.

Bibliography

Goodman, S. R., Riederer, B. M., & Zagon, L. S. (1986). Spectrin subtypes in mammalian brain. BioEssays, 5(1), 25â29. Portico.

Authors 3

Steven R. Goodman (first)
Beat M. Riederer (additional)
Lan S. Zagon (additional)

References 22 Referenced 12

10.1152/ajpcell.1983.244.3.C121
10.1073/pnas.81.14.4404
{'key': 'e_1_2_1_4_2', 'first-page': '415', 'volume-title': 'The Red Cell: Sixth Ann Arbor Conference', 'author': 'Goodman S. R.', 'year': '1984'} / The Red Cell: Sixth Ann Arbor Conference by Goodman S. R. (1984)
10.1016/S0021-9258(18)34761-6 / J. Biol. Chem. / Erythrocyte membrane skeletal protein bands 4. la and 4. lb are sequence‐related phosphoproteins by Goodman S. R. (1982)
10.1073/pnas.78.12.7570
10.1016/0361-9230(84)90239-9
Goodman S. R.&Zagon I. S.(1985). The neural cell spectrin skeleton: a review.Am. J. Physiol.(in press).
10.1016/S0021-9258(18)90728-3 / J. Biol. Chem. / Brain ankyrin: a membrane‐associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel by Davis J. Q. (1984)
10.1016/S0021-9258(18)34140-1
Goodman S. R. Krebs K. E. Zagon I. S.&Sihag R. K.(1986).Brain protein 4. 1 subtypes: a working hypothesis. Submitted.
{'key': 'e_1_2_1_12_2', 'first-page': '287a', 'article-title': 'Synapsin I, a species of brain protein 4. 1, binds to the ends of brain spectrin tetramer', 'volume': '101', 'author': 'Krebs K. E.', 'year': '1985', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. / Synapsin I, a species of brain protein 4. 1, binds to the ends of brain spectrin tetramer by Krebs K. E. (1985)
10.1152/ajpcell.1984.247.1.C61 / Am. J. Physiol. / A spectrin‐like protein from mouse brain membranes: phosphorylation of the 235,000 dalton subunit by Goodman S. R. (1984)
10.1083/jcb.97.2.574
10.1111/j.1432-1033.1984.tb08498.x
10.1083/jcb.90.3.631
10.1002/cm.970030529
10.1523/JNEUROSCI.04-12-03089.1984 / J. Neurosci. / Localization of spectrin in mammalian brain by Zagon I. S. (1984)
{'key': 'e_1_2_1_19_2', 'first-page': '286a', 'article-title': 'Distinct spectrin subtypes in mammalian brain', 'volume': '101', 'author': 'Riederer B. M.', 'year': '1985', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. / Distinct spectrin subtypes in mammalian brain by Riederer B. M. (1985)
Riederer B. M. Zagon I. S.&Goodman S. R.(1986). Brain spectrin (240/235) and brain spectrin (240/235E): two distinct spectrin subtypes with different locations within mammalian neural cells.J. Cell Biol.(in press) (10.1083/jcb.102.6.2088)
10.1126/science.6190228
10.1126/science.6356364
10.1111/j.1462-5822.2007.00901.x

Dates

Type	When
Created	20 years, 6 months ago (Feb. 25, 2005, 7:02 a.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 9:59 p.m.)
Indexed	1 year, 10 months ago (Oct. 22, 2023, 10:28 a.m.)
Issued	39 years, 8 months ago (Jan. 1, 1986)
Published	39 years, 8 months ago (Jan. 1, 1986)
Published Online	20 years, 6 months ago (Feb. 5, 2005)
Published Print	39 years, 8 months ago (Jan. 1, 1986)

Funders 0

None

BibTeX

@article{Goodman_1986, title={Spectrin subtypes in mammalian brain}, volume={5}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.950050108}, DOI={10.1002/bies.950050108}, number={1}, journal={BioEssays}, publisher={Wiley}, author={Goodman, Steven R. and Riederer, Beat M. and Zagon, Lan S.}, year={1986}, month=jan, pages={25–29} }

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