DOI: 10.1002/bies.20388. Polycomb, trithorax and the decision to differentiate

Polycomb, trithorax and the decision to differentiate

10.1002/bies.20388

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractFor stem cells, life is full of potential: they have a high capacity to proliferate and a wide choice of future identities. When they differentiate, cells leave behind this freedom and become ever more committed to a single fate. Intriguingly, the Polycomb and Trithorax groups of proteins are vital to the very different natures of both stem cells and differentiated cells, but little is known about how they make the transition from one cell type to the other. A recent paper1 throws light on this mystery, showing that the Polycomb proteins dramatically change their behaviour at a crucial moment of differentiation. BioEssays 28: 330–334, 2006. © 2006 Wiley Periodicals, Inc.

Bibliography

Ringrose, L. (2006). Polycomb, trithorax and the decision to differentiate. BioEssays, 28(4), 330â334. Portico.

Authors 1

Leonie Ringrose (first)

References 30 Referenced 9

10.1126/science.1118101
10.1146/annurev.genet.38.072902.091907
10.1126/science.308.5722.624
10.1101/sqb.2004.69.319
10.1016/S1534-5807(03)00337-X
10.1146/annurev.genet.32.1.495
10.1016/j.cell.2004.08.005
10.1038/16476
10.1016/S0092-8674(00)81181-2
10.1242/dev.128.6.993
10.1128/MCB.22.22.8026-8034.2002
10.1242/dev.129.21.4915 / Development / Transcription through the iab‐7 cis‐regulatory domain of the bithorax complex interferes with maintenance of Polycomb‐mediated silencing by Hogga I (2002)
10.1242/dev.129.21.4923
10.1101/gad.326205
10.1242/dev.125.1.125
10.1242/dev.01373
10.1242/dev.01314
10.1101/gad.1099903
10.1242/jcs.01736
10.1038/nature03207
10.1007/s004120050355
10.1016/S0968-0004(99)01535-2
10.1016/j.molcel.2004.10.015
10.1242/dev.01950
10.1016/S0092-8674(03)00159-4
10.1038/nature02985
10.1016/j.devcel.2004.10.005
10.1038/nature02017
10.1038/nature02385
10.1038/nature04120

Dates

Type	When
Created	19 years, 5 months ago (March 17, 2006, 4:49 p.m.)
Deposited	1 year, 9 months ago (Nov. 15, 2023, 11:28 a.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 3:08 p.m.)
Issued	19 years, 5 months ago (March 17, 2006)
Published	19 years, 5 months ago (March 17, 2006)
Published Online	19 years, 5 months ago (March 17, 2006)
Published Print	19 years, 4 months ago (April 1, 2006)

Funders 0

None

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