DOI: 10.1002/bies.201000088. SMN and Gemins: ‘We are family’ … or are we?

SMN and Gemins: ‘We are family’ … or are we?

10.1002/bies.201000088

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractGemins 2–8 and Unr‐interacting protein (UNRIP) are intimate partners of the survival motor neuron (SMN) protein, which is the determining factor for the neuromuscular disorder spinal muscular atrophy (SMA). The most documented role of SMN, Gemins and UNRIP occurs within the large macromolecular SMN complex and involves the cytoplasmic assembly of spliceosomal uridine‐rich small nuclear ribonucleoproteins (UsnRNPs), a housekeeping process critical in all cells. Several reports detailing alternative functions for SMN in either motor neurons or skeletal muscles may, however, hold the answer to the extreme neuromuscular tissue specificity observed in SMA. Recent discoveries indicate that collaboration between SMN and Gemins also extends to these non‐canonical functions, hence raising the possibility that mutations in Gemin genes may be the cause of unlinked neuromuscular hereditary syndromes. This review evaluates the functions of Gemins and UNRIP inside the SMN complex and discusses whether these less notorious SMN complex members are capable of acting independently of SMN.

Bibliography

Cauchi, R. J. (2010). SMN and Gemins: âWe are familyâ â¦ or are we? BioEssays, 32(12), 1077â1089. Portico.

Authors 1

Ruben J. Cauchi (first)

References 120 Referenced 93

Dates

Type	When
Created	14 years, 10 months ago (Oct. 15, 2010, 2:56 a.m.)
Deposited	1 year, 10 months ago (Oct. 16, 2023, 7:55 p.m.)
Indexed	1 day, 7 hours ago (Aug. 21, 2025, 12:57 p.m.)
Issued	14 years, 10 months ago (Oct. 15, 2010)
Published	14 years, 10 months ago (Oct. 15, 2010)
Published Online	14 years, 10 months ago (Oct. 15, 2010)
Published Print	14 years, 8 months ago (Dec. 1, 2010)

Funders 0

None

BibTeX

@article{Cauchi_2010, title={SMN and Gemins: ‘We are family’ … or are we?: Insights into the partnership between Gemins and the spinal muscular atrophy disease protein SMN}, volume={32}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.201000088}, DOI={10.1002/bies.201000088}, number={12}, journal={BioEssays}, publisher={Wiley}, author={Cauchi, Ruben J.}, year={2010}, month=oct, pages={1077–1089} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        21
      ]
    ],
    "date-time": "2025-08-21T16:57:55Z",
    "timestamp": 1755795475375
  },
  "reference-count": 120,
  "publisher": "Wiley",
  "issue": "12",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2010,
            10,
            15
          ]
        ],
        "date-time": "2010-10-15T00:00:00Z",
        "timestamp": 1287100800000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [
      "onlinelibrary.wiley.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2010,
        12
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Gemins 2\u20138 and Unr\u2010interacting protein (UNRIP) are intimate partners of the survival motor neuron (SMN) protein, which is the determining factor for the neuromuscular disorder spinal muscular atrophy (SMA). The most documented role of SMN, Gemins and UNRIP occurs within the large macromolecular SMN complex and involves the cytoplasmic assembly of spliceosomal uridine\u2010rich small nuclear ribonucleoproteins (UsnRNPs), a housekeeping process critical in all cells. Several reports detailing alternative functions for SMN in either motor neurons or skeletal muscles may, however, hold the answer to the extreme neuromuscular tissue specificity observed in SMA. Recent discoveries indicate that collaboration between SMN and Gemins also extends to these non\u2010canonical functions, hence raising the possibility that mutations in Gemin genes may be the cause of unlinked neuromuscular hereditary syndromes. This review evaluates the functions of Gemins and UNRIP inside the SMN complex and discusses whether these less notorious SMN complex members are capable of acting independently of SMN.</jats:p>",
  "DOI": "10.1002/bies.201000088",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2010,
        10,
        15
      ]
    ],
    "date-time": "2010-10-15T06:56:34Z",
    "timestamp": 1287125794000
  },
  "page": "1077-1089",
  "update-policy": "http://dx.doi.org/10.1002/crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 93,
  "title": "SMN and Gemins: \u2018We are family\u2019 \u2026 or are we?",
  "prefix": "10.1002",
  "volume": "32",
  "author": [
    {
      "given": "Ruben J.",
      "family": "Cauchi",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2010,
        10,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_10_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.nmd.2008.10.004"
    },
    {
      "key": "e_1_2_10_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/400_2009_4"
    },
    {
      "key": "e_1_2_10_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nrn2670"
    },
    {
      "key": "e_1_2_10_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00725.x"
    },
    {
      "key": "e_1_2_10_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.96.20.11167"
    },
    {
      "key": "e_1_2_10_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ng0598-63"
    },
    {
      "key": "e_1_2_10_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/9.19.2869"
    },
    {
      "key": "e_1_2_10_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80367-0"
    },
    {
      "key": "e_1_2_10_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.147.6.1181"
    },
    {
      "key": "e_1_2_10_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.148.6.1177"
    },
    {
      "key": "e_1_2_10_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M109448200"
    },
    {
      "key": "e_1_2_10_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M110141200"
    },
    {
      "key": "e_1_2_10_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M203478200"
    },
    {
      "key": "e_1_2_10_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M512243200"
    },
    {
      "key": "e_1_2_10_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M607505200"
    },
    {
      "key": "e_1_2_10_17_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.febslet.2005.03.034"
    },
    {
      "key": "e_1_2_10_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/9.7.1093"
    },
    {
      "key": "e_1_2_10_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddi343"
    },
    {
      "key": "e_1_2_10_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80368-2"
    },
    {
      "key": "e_1_2_10_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nrm2124"
    },
    {
      "key": "e_1_2_10_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nrm1259"
    },
    {
      "key": "e_1_2_10_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M608528200"
    },
    {
      "key": "e_1_2_10_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M809031200"
    },
    {
      "key": "e_1_2_10_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M609297200"
    },
    {
      "key": "e_1_2_10_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M702317200"
    },
    {
      "key": "e_1_2_10_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1186/1471-2121-8-28"
    },
    {
      "key": "e_1_2_10_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddn320"
    },
    {
      "key": "e_1_2_10_29_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1371/journal.pgen.1000265"
    },
    {
      "key": "e_1_2_10_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddg157"
    },
    {
      "key": "e_1_2_10_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.18.9920"
    },
    {
      "key": "e_1_2_10_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1210/en.2007-1237"
    },
    {
      "key": "e_1_2_10_33_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.152318699"
    },
    {
      "key": "e_1_2_10_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1242/dev.00920"
    },
    {
      "key": "e_1_2_10_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/9.5.663"
    },
    {
      "key": "e_1_2_10_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/9.5.675"
    },
    {
      "key": "e_1_2_10_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.E08-01-0024"
    },
    {
      "key": "e_1_2_10_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0802287105"
    },
    {
      "key": "e_1_2_10_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M003299200"
    },
    {
      "key": "e_1_2_10_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ncb1101-945"
    },
    {
      "key": "e_1_2_10_41_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.19.10.6554"
    },
    {
      "key": "e_1_2_10_42_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/cdf585"
    },
    {
      "key": "e_1_2_10_43_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/8.13.2351"
    },
    {
      "key": "e_1_2_10_44_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0508947102"
    },
    {
      "key": "e_1_2_10_45_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddi168"
    },
    {
      "key": "e_1_2_10_46_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.ceb.2009.02.004"
    },
    {
      "key": "e_1_2_10_47_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cell.2008.09.020"
    },
    {
      "key": "e_1_2_10_48_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/sqb.2006.71.001"
    },
    {
      "key": "e_1_2_10_49_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.molcel.2006.05.036"
    },
    {
      "key": "e_1_2_10_50_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nsmb.1584"
    },
    {
      "key": "e_1_2_10_51_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.str.2005.03.014"
    },
    {
      "key": "e_1_2_10_52_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.molcel.2010.03.014"
    },
    {
      "key": "e_1_2_10_53_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.23.1.414-423.2003"
    },
    {
      "key": "e_1_2_10_54_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/cshperspect.a000653"
    },
    {
      "key": "e_1_2_10_55_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200104083"
    },
    {
      "key": "e_1_2_10_56_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1371/journal.pone.0006171"
    },
    {
      "key": "e_1_2_10_57_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.e08-05-0525"
    },
    {
      "key": "e_1_2_10_58_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.yexcr.2003.08.022"
    },
    {
      "key": "e_1_2_10_59_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s00412-004-0285-5"
    },
    {
      "key": "e_1_2_10_60_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.147.4.715"
    },
    {
      "key": "e_1_2_10_61_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200311121"
    },
    {
      "key": "e_1_2_10_62_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/excr.2000.4858"
    },
    {
      "key": "e_1_2_10_63_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/excr.2001.5186"
    },
    {
      "key": "e_1_2_10_64_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1534-5807(02)00222-8"
    },
    {
      "key": "e_1_2_10_65_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.908401"
    },
    {
      "key": "e_1_2_10_66_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200207028"
    },
    {
      "key": "e_1_2_10_67_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddm192"
    },
    {
      "key": "e_1_2_10_68_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.25.7.2744-2756.2005"
    },
    {
      "key": "e_1_2_10_69_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200704163"
    },
    {
      "key": "e_1_2_10_70_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.E06-03-0247"
    },
    {
      "key": "e_1_2_10_71_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/gkl374"
    },
    {
      "key": "e_1_2_10_72_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200511038"
    },
    {
      "key": "e_1_2_10_73_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.0704977104"
    },
    {
      "key": "e_1_2_10_74_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.yexcr.2010.05.001"
    },
    {
      "key": "e_1_2_10_75_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nrm2080"
    },
    {
      "key": "e_1_2_10_76_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.ydbio.2009.05.553"
    },
    {
      "key": "e_1_2_10_77_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.E09-09-0777"
    },
    {
      "key": "e_1_2_10_78_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.devcel.2009.10.017"
    },
    {
      "key": "e_1_2_10_79_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nsmb.1783"
    },
    {
      "key": "e_1_2_10_80_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.25.13.5543-5551.2005"
    },
    {
      "key": "e_1_2_10_81_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddi390"
    },
    {
      "key": "e_1_2_10_82_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.cell.2008.03.031"
    },
    {
      "key": "e_1_2_10_83_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1371/journal.pgen.1000773"
    },
    {
      "key": "e_1_2_10_84_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/9.1.47"
    },
    {
      "key": "e_1_2_10_85_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1460-9568.1999.00428.x"
    },
    {
      "key": "e_1_2_10_86_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/10.5.497"
    },
    {
      "key": "e_1_2_10_87_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/11.14.1605"
    },
    {
      "key": "e_1_2_10_88_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.23-16-06627.2003"
    },
    {
      "key": "e_1_2_10_89_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.3967-05.2006"
    },
    {
      "key": "e_1_2_10_90_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.bbrc.2010.02.158"
    },
    {
      "key": "e_1_2_10_91_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.bbrc.2010.05.139"
    },
    {
      "key": "e_1_2_10_92_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1371/journal.pone.0003209"
    },
    {
      "key": "e_1_2_10_93_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/11.1.93"
    },
    {
      "key": "e_1_2_10_94_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.yexcr.2005.05.014"
    },
    {
      "key": "e_1_2_10_95_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200304128"
    },
    {
      "key": "e_1_2_10_96_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddq073"
    },
    {
      "key": "e_1_2_10_97_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200703187"
    },
    {
      "key": "e_1_2_10_98_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.342005"
    },
    {
      "key": "e_1_2_10_99_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1523/JNEUROSCI.1637-06.2006"
    },
    {
      "key": "e_1_2_10_100_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.200610053"
    },
    {
      "key": "e_1_2_10_101_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddn234"
    },
    {
      "key": "e_1_2_10_102_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/hmg/ddm379"
    },
    {
      "key": "e_1_2_10_103_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.974702"
    },
    {
      "key": "e_1_2_10_104_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1261/rna.5181104"
    },
    {
      "key": "e_1_2_10_105_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fj.06-6155com"
    },
    {
      "key": "e_1_2_10_106_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/gkn979"
    },
    {
      "key": "e_1_2_10_107_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.13.4.437"
    },
    {
      "key": "e_1_2_10_108_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/pr900884g"
    },
    {
      "key": "e_1_2_10_109_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/pr9006987"
    },
    {
      "key": "e_1_2_10_110_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/gkq271"
    },
    {
      "key": "e_1_2_10_111_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1371/journal.pone.0007825"
    },
    {
      "key": "e_1_2_10_112_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.embor.7401088"
    },
    {
      "key": "e_1_2_10_113_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/s12192-010-0169-y"
    },
    {
      "key": "e_1_2_10_114_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.27.19136"
    },
    {
      "key": "e_1_2_10_115_2",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1210/mend.15.1.0580",
      "article-title": "The DEAD box protein DP103 is a regulator of steroidogenic factor\u20101",
      "volume": "15",
      "author": "Ou Q",
      "year": "2001",
      "journal-title": "Mol Endocrinol"
    },
    {
      "key": "e_1_2_10_116_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M309308200"
    },
    {
      "key": "e_1_2_10_117_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(02)00714-6"
    },
    {
      "key": "e_1_2_10_118_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/j.bbrc.2005.08.184"
    },
    {
      "key": "e_1_2_10_119_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/29.17.3595"
    },
    {
      "key": "e_1_2_10_120_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1371/journal.pone.0007030"
    },
    {
      "key": "e_1_2_10_121_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/pr0504539"
    }
  ],
  "container-title": "BioEssays",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbies.201000088",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.201000088",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        10,
        16
      ]
    ],
    "date-time": "2023-10-16T23:55:08Z",
    "timestamp": 1697500508000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/bies.201000088"
    }
  },
  "subtitle": [
    "Insights into the partnership between Gemins and the spinal muscular atrophy disease protein SMN"
  ],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2010,
        10,
        15
      ]
    ]
  },
  "references-count": 120,
  "journal-issue": {
    "issue": "12",
    "published-print": {
      "date-parts": [
        [
          2010,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/bies.201000088"
  ],
  "URL": "http://dx.doi.org/10.1002/bies.201000088",
  "relation": {},
  "ISSN": [
    "0265-9247",
    "1521-1878"
  ],
  "subject": [],
  "container-title-short": "BioEssays",
  "published": {
    "date-parts": [
      [
        2010,
        10,
        15
      ]
    ]
  },
  "assertion": [
    {
      "value": "2010-10-15",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}