DOI: 10.1002/bies.1132. Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition

Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition

10.1002/bies.1132

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractSeveral molecular mechanisms contribute directly and mechanically to the loss of epithelial phenotype. During epithelial–mesenchymal transition (EMT), adherens junctions and desmosomes are at least partially dissociated. At the same time, a massive cytoskeleton reorganization takes place, involving the rho family and the remodeling of the actin microfilament mesh. Numerous pathways have been described in vitro that control phenotype transition in specific cell models. In vivo developmental studies suggest that transcriptional control, activated by a specific pathway involving Ras, Src and potentially the Wnt pathway, is an essential step. Recent functional and localization experiments indicate that the slug/snail family of transcription factors functions overall as an epithelial phenotype repressor and could represent a key EMT contributor. BioEssays 23:912–923, 2001. © 2001 John Wiley & Sons, Inc.

Bibliography

Savagner, P. (2001). Leaving the neighborhood: molecular mechanisms involved during epithelialâmesenchymal transition. BioEssays, 23(10), 912â923. Portico.

Authors 1

P. Savagner (first)

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Dates

Type	When
Created	23 years ago (Aug. 25, 2002, 3:53 p.m.)
Deposited	1 year, 10 months ago (Sept. 28, 2023, 7:17 p.m.)
Indexed	1 month ago (July 24, 2025, 8:30 a.m.)
Issued	23 years, 11 months ago (Sept. 25, 2001)
Published	23 years, 11 months ago (Sept. 25, 2001)
Published Online	23 years, 11 months ago (Sept. 25, 2001)
Published Print	23 years, 10 months ago (Oct. 1, 2001)

Funders 0

None

BibTeX

@article{Savagner_2001, title={Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition}, volume={23}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.1132}, DOI={10.1002/bies.1132}, number={10}, journal={BioEssays}, publisher={Wiley}, author={Savagner, P.}, year={2001}, month=sep, pages={912–923} }

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