DOI: 10.1002/bies.1074. A cellular survival switch: poly(ADP‐ribosyl)ation stimulates DNA repair and silences transcription

A cellular survival switch: poly(ADP‐ribosyl)ation stimulates DNA repair and silences transcription

10.1002/bies.1074

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractPoly(ADP‐ribosyl)ation is a post‐translational modification occurring in the nucleus. The most abundant and best‐characterized enzyme catalyzing this reaction, poly(ADP‐ribose) polymerase 1 (PARP1), participates in fundamental nuclear events. The enzyme functions as molecular “nick sensor”. It binds with high affinity to DNA single‐strand breaks resulting in the initiation of its catalytic activity. Activated PARP1 promotes base excision repair. In addition, PARP1 modifies several transcription factors and thereby precludes their binding to DNA. We propose that a major function of PARP1 includes the silencing of transcription preventing expression of damaged genes. Concomitant stimulation of DNA repair suggests that PARP1 acts as a switch between transcription and DNA repair. Another PARP‐type enzyme, tankyrase, is involved in the regulation of telomere elongation. Tankyrase modifies a telomere‐associated protein and thereby prevents it masking telomeric repeats providing access of telomerase for telomere elongation. Therefore, poly(ADP‐ribosyl)ation reactions may act as molecular switches in DNA metabolism. BioEssays 23:543–548, 2001. © 2001 John Wiley & Sons, Inc.

Bibliography

Ziegler, M., & Oei, S. L. (2001). A cellular survival switch: poly(ADPâribosyl)ation stimulates DNA repair and silences transcription. BioEssays, 23(6), 543â548. Portico.

Authors 2

Mathias Ziegler (first)
Shiao Li Oei (additional)

References 49 Referenced 91

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{'key': 'e_1_2_1_4_2', 'first-page': '127', 'article-title': 'The role of poly(ADP‐ribosyl)ation', 'volume': '131', 'author': 'Oei SL', 'year': '1997', 'journal-title': 'Rev Physiol Biochem Pharmacol'} / Rev Physiol Biochem Pharmacol / The role of poly(ADP‐ribosyl)ation by Oei SL (1997)
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Dates

Type	When
Created	22 years, 11 months ago (Sept. 10, 2002, 7:33 p.m.)
Deposited	1 year, 9 months ago (Nov. 19, 2023, 11:38 a.m.)
Indexed	2 months ago (July 2, 2025, 3:07 p.m.)
Issued	24 years, 3 months ago (May 25, 2001)
Published	24 years, 3 months ago (May 25, 2001)
Published Online	24 years, 3 months ago (May 25, 2001)
Published Print	24 years, 3 months ago (June 1, 2001)

Funders 0

None

BibTeX

@article{Ziegler_2001, title={A cellular survival switch: poly(ADP‐ribosyl)ation stimulates DNA repair and silences transcription}, volume={23}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.1074}, DOI={10.1002/bies.1074}, number={6}, journal={BioEssays}, publisher={Wiley}, author={Ziegler, Mathias and Oei, Shiao Li}, year={2001}, month=may, pages={543–548} }

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