DOI: 10.1002/bies.10392. The many colours of chromodomains

10.1002/bies.10392

Crossref journal-article

Wiley

BioEssays (311)

Abstract

AbstractLocal differences in chromatin organisation may profoundly affect the activity of eukaryotic genomes. Regulation at the level of DNA packaging requires the targeting of structural proteins and histone‐modifying enzymes to specific sites and their stable or dynamic interaction with the nucleosomal fiber. The “chromodomain”, a domain shared by many regulators of chromatin structure, has long been suspected to serve as a module mediating chromatin interactions in a variety of different protein contexts. However, recent functional analyses of a number of different chromodomains revealed an unexpected diversity of interaction targets, including histones, DNA and even RNA. The chromodomains of today seem to have evolved from a common ancestral fold to fulfill various functions in different molecular contexts. Combining information gained from recent functional and structural studies of chromodomains with a bioinformatic classification of their structure could lead to the definition of sequence motifs with predictive quality for chromodomain function. BioEssays 26:133–140, 2004. © 2004 Wiley Periodicals, Inc.

Bibliography

Brehm, A., Tufteland, K. R., Aasland, R., & Becker, P. B. (2004). The many colours of chromodomains. BioEssays, 26(2), 133â140. Portico.

Authors 4

Alexander Brehm (first)
Katharina R. Tufteland (additional)
Rein Aasland (additional)
Peter B. Becker (additional)

References 72 Referenced 137

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Dates

Type	When
Created	21 years, 7 months ago (Jan. 22, 2004, 4 a.m.)
Deposited	1 year, 9 months ago (Nov. 17, 2023, 7:58 p.m.)
Indexed	1 month, 1 week ago (July 20, 2025, 6:45 p.m.)
Issued	21 years, 7 months ago (Jan. 21, 2004)
Published	21 years, 7 months ago (Jan. 21, 2004)
Published Online	21 years, 7 months ago (Jan. 21, 2004)
Published Print	21 years, 6 months ago (Feb. 1, 2004)

Funders 0

None

BibTeX

@article{Brehm_2004, title={The many colours of chromodomains}, volume={26}, ISSN={1521-1878}, url={http://dx.doi.org/10.1002/bies.10392}, DOI={10.1002/bies.10392}, number={2}, journal={BioEssays}, publisher={Wiley}, author={Brehm, Alexander and Tufteland, Katharina R. and Aasland, Rein and Becker, Peter B.}, year={2004}, month=jan, pages={133–140} }

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