DOI: 10.1002/art.10112. Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis

Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis

10.1002/art.10112

Crossref journal-article

Wiley

Arthritis & Rheumatism (311)

Abstract

AbstractObjectiveSome chemokine receptors, such as CCR5 and CCR4, are differentially expressed on Th1 and Th2 cells. To determine whether differential expression of the chemokine receptors occurs in patients with lupus nephritis, we examined the expression of CCR4 and CCR5 on peripheral blood lymphocytes and mononuclear cells infiltrated into the renal tissue of patients with lupus nephritis.MethodsThe expression of CCR4 and CCR5 on CD4+,CD45RO+ cells was analyzed by flow cytometry and compared between patients with systemic lupus erythematosus (SLE) and healthy controls. Correlation between the absolute number of CCR4+ or CCR5+ cells and clinical parameters was also analyzed. Mononuclear infiltrates in the renal tissue of SLE patients were analyzed for the expression of CCR4, CCR5, and CD4 by immunohistochemical staining.ResultsThe absolute number of CCR4+, but not CCR5+, T lymphocytes in the peripheral blood was significantly decreased in the patients with SLE compared with that in the healthy controls, and this positively correlated with the serum levels of C3 and CH50. Most of the CD4+ T lymphocytes that infiltrated into the renal tissue of the patients with lupus nephritis expressed CCR4, but not CCR5.ConclusionThese results suggest that CCR4+ T lymphocytes in peripheral blood, which represent Th2 cells, preferentially migrate into the renal tissue of patients with lupus nephritis. The maldistribution of CCR4+ T lymphocytes might be involved in the pathogenesis of lupus nephritis.

Bibliography

Yamada, M., Yagita, H., Inoue, H., Takanashi, T., Matsuda, H., Munechika, E., Kanamaru, Y., Shirato, I., Tomino, Y., Matushima, K., Okumura, K., & Hashimoto, H. (2002). Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis. Arthritis & Rheumatism, 46(3), 735â740. Portico.

Authors 12

Masato Yamada (first)
Hideo Yagita (additional)
Hideko Inoue (additional)
Tsuyoshi Takanashi (additional)
Hironori Matsuda (additional)
Eiko Munechika (additional)
Yutaka Kanamaru (additional)
Isao Shirato (additional)
Yasuhiko Tomino (additional)
Kouji Matushima (additional)
Ko Okumura (additional)
Hiroshi Hashimoto (additional)

References 13 Referenced 34

10.1080/030097498440859
10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L
10.1111/j.1600-065X.1995.tb00069.x
10.1084/jem.187.1.129
10.1126/science.277.5334.2005
10.1093/intimm/11.1.81
10.4049/jimmunol.161.2.547 / J Immunol / The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells by Zingoni A (1998)
10.1038/34814
10.1172/JCI1422
10.1002/art.1780251101
10.1002/art.1780350606
10.1093/intimm/11.4.553
10.4049/jimmunol.161.10.5111 / J Immunol / Selective up‐regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells by D'Ambrosio D (1998)

Dates

Type	When
Created	22 years, 11 months ago (Oct. 6, 2002, 8 a.m.)
Deposited	1 year, 9 months ago (Nov. 22, 2023, 8:14 p.m.)
Indexed	1 month, 2 weeks ago (July 24, 2025, 8:20 a.m.)
Issued	23 years, 6 months ago (March 1, 2002)
Published	23 years, 6 months ago (March 1, 2002)
Published Online	23 years, 6 months ago (March 7, 2002)
Published Print	23 years, 6 months ago (March 1, 2002)

Funders 0

None

BibTeX

@article{Yamada_2002, title={Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis}, volume={46}, ISSN={1529-0131}, url={http://dx.doi.org/10.1002/art.10112}, DOI={10.1002/art.10112}, number={3}, journal={Arthritis & Rheumatism}, publisher={Wiley}, author={Yamada, Masato and Yagita, Hideo and Inoue, Hideko and Takanashi, Tsuyoshi and Matsuda, Hironori and Munechika, Eiko and Kanamaru, Yutaka and Shirato, Isao and Tomino, Yasuhiko and Matushima, Kouji and Okumura, Ko and Hashimoto, Hiroshi}, year={2002}, month=mar, pages={735–740} }

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