DOI: 10.1002/app.13354. Direct synthesis of poly(<scp>D,L</scp>‐lactic acid) by melt polycondensation and its application in drug delivery

Direct synthesis of poly(D,L‐lactic acid) by melt polycondensation and its application in drug delivery

10.1002/app.13354

Crossref journal-article

Wiley

Journal of Applied Polymer Science (311)

Abstract

AbstractStarting from D,L‐acid and SnCl2 as catalyst, poly(D,L‐lactic acid) (PDLLA) was directly synthesized by melt polycondensation. Under the appropriate conditions such as 0.5 wt % SnCl2, 170–180°C, 70 Pa, and 10 h, the viscosity‐average molecular weight (Mη) of PDLLA was 4100 Da. PDLLA produced by the most practical method was used as the drug‐delivery material for erythromycin and ciprofloxacin. The optimal conditions for the preparation of erythromycin–poly(D,L‐lactic acid)–microsphere (ERY–PDLLA–MS) for lung targeting was investigated, and further confirmed by good reappearance tests. DSC and SEM demonstrated that ERY–PDLLA–MS had good spherical shape. The release in vitro of ERY–PDLLA–MS was effective and the half‐time (T1/2) was 51.0 h. After 175 h, the accumulated release percentage was 80.0%. The test in vivo showed that ERY–PDLLA–MS was more easily distributed in rabbit lung tissue. When PDLLA was applied in an antibacterial ciprofloxacin drug‐delivery microsphere (CIP–PDLLA–MS), CIP–PDLLA–MS was also characterized with DSC and SEM, and the release T1/2 in vitro was 24.9 h. After 53.2 h, the accumulated release percentage reached 84.0%, which indicated that CIP–PDLLA–MS was advantageous to long‐term release. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2143–2150, 2004

Bibliography

Zhao, Y., Wang, Z., Wang, J., Mai, H., Yan, B., & Yang, F. (2003). Direct synthesis of poly(D,Lâlactic acid) by melt polycondensation and its application in drug delivery. Journal of Applied Polymer Science, 91(4), 2143â2150. Portico.

Authors 6

Yaoming Zhao (first)
Zhaoyang Wang (additional)
Jun Wang (additional)
Hangzhen Mai (additional)
Bing Yan (additional)
Fan Yang (additional)

References 12 Referenced 65

10.1016/S0045-6535(00)00323-4
10.1246/bcsj.68.2125
{'issue': '2', 'key': 'e_1_2_6_4_2', 'first-page': '366', 'volume': '42', 'author': 'Mai H. Z.', 'year': '2001', 'journal-title': 'Polymer Preprints'} / Polymer Preprints by Mai H. Z. (2001)
10.1002/(SICI)1099-0518(20000501)38:9<1673::AID-POLA33>3.0.CO;2-T
10.1016/S0032-3861(00)00889-2
{'issue': '1', 'key': 'e_1_2_6_7_2', 'first-page': '526', 'volume': '43', 'author': 'Mai H. Z.', 'year': '2002', 'journal-title': 'Polymer Preprints'} / Polymer Preprints by Mai H. Z. (2002)
{'issue': '1', 'key': 'e_1_2_6_8_2', 'first-page': '528', 'volume': '43', 'author': 'Wang Z. Y.', 'year': '2002', 'journal-title': 'Polymer Preprints'} / Polymer Preprints by Wang Z. Y. (2002)
10.1002/pol.1979.170170831
10.1081/DDC-100100328
10.1016/S0378-5173(98)00019-2
10.1002/jps.2600690703
10.3109/02652049109021862

Dates

Type	When
Created	21 years, 8 months ago (Dec. 23, 2003, 5 a.m.)
Deposited	1 year, 11 months ago (Sept. 25, 2023, 12:37 a.m.)
Indexed	4 months ago (April 30, 2025, 7:27 a.m.)
Issued	21 years, 8 months ago (Dec. 8, 2003)
Published	21 years, 8 months ago (Dec. 8, 2003)
Published Online	21 years, 8 months ago (Dec. 8, 2003)
Published Print	21 years, 6 months ago (Feb. 15, 2004)

Funders 0

None

BibTeX

@article{Zhao_2003, title={Direct synthesis of poly(<scp>D,L</scp>‐lactic acid) by melt polycondensation and its application in drug delivery}, volume={91}, ISSN={1097-4628}, url={http://dx.doi.org/10.1002/app.13354}, DOI={10.1002/app.13354}, number={4}, journal={Journal of Applied Polymer Science}, publisher={Wiley}, author={Zhao, Yaoming and Wang, Zhaoyang and Wang, Jun and Mai, Hangzhen and Yan, Bing and Yang, Fan}, year={2003}, month=dec, pages={2143–2150} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        4,
        30
      ]
    ],
    "date-time": "2025-04-30T11:27:16Z",
    "timestamp": 1746012436898
  },
  "reference-count": 12,
  "publisher": "Wiley",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2003,
            12,
            8
          ]
        ],
        "date-time": "2003-12-08T00:00:00Z",
        "timestamp": 1070841600000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        2,
        15
      ]
    ]
  },
  "abstract": "<jats:title>Abstract</jats:title><jats:p>Starting from <jats:sc>D,L</jats:sc>\u2010acid and SnCl<jats:sub>2</jats:sub> as catalyst, poly(<jats:sc>D,L</jats:sc>\u2010lactic acid) (PDLLA) was directly synthesized by melt polycondensation. Under the appropriate conditions such as 0.5 wt % SnCl<jats:sub>2</jats:sub>, 170\u2013180\u00b0C, 70 Pa, and 10 h, the viscosity\u2010average molecular weight (<jats:italic>M</jats:italic><jats:sub>\u03b7</jats:sub>) of PDLLA was 4100 Da. PDLLA produced by the most practical method was used as the drug\u2010delivery material for erythromycin and ciprofloxacin. The optimal conditions for the preparation of erythromycin\u2013poly(<jats:sc>D,L</jats:sc>\u2010lactic acid)\u2013microsphere (ERY\u2013PDLLA\u2013MS) for lung targeting was investigated, and further confirmed by good reappearance tests. DSC and SEM demonstrated that ERY\u2013PDLLA\u2013MS had good spherical shape. The release <jats:italic>in vitro</jats:italic> of ERY\u2013PDLLA\u2013MS was effective and the half\u2010time (<jats:italic>T</jats:italic><jats:sub>1/2</jats:sub>) was 51.0 h. After 175 h, the accumulated release percentage was 80.0%. The test <jats:italic>in vivo</jats:italic> showed that ERY\u2013PDLLA\u2013MS was more easily distributed in rabbit lung tissue. When PDLLA was applied in an antibacterial ciprofloxacin drug\u2010delivery microsphere (CIP\u2013PDLLA\u2013MS), CIP\u2013PDLLA\u2013MS was also characterized with DSC and SEM, and the release <jats:italic>T</jats:italic><jats:sub>1/2</jats:sub> <jats:italic>in vitro</jats:italic> was 24.9 h. After 53.2 h, the accumulated release percentage reached 84.0%, which indicated that CIP\u2013PDLLA\u2013MS was advantageous to long\u2010term release. \u00a9 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 2143\u20132150, 2004</jats:p>",
  "DOI": "10.1002/app.13354",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        12,
        23
      ]
    ],
    "date-time": "2003-12-23T10:00:40Z",
    "timestamp": 1072173640000
  },
  "page": "2143-2150",
  "source": "Crossref",
  "is-referenced-by-count": 65,
  "title": "Direct synthesis of poly(<scp>D,L</scp>\u2010lactic acid) by melt polycondensation and its application in drug delivery",
  "prefix": "10.1002",
  "volume": "91",
  "author": [
    {
      "given": "Yaoming",
      "family": "Zhao",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Zhaoyang",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jun",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hangzhen",
      "family": "Mai",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Bing",
      "family": "Yan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Fan",
      "family": "Yang",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2003,
        12,
        8
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_6_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0045-6535(00)00323-4"
    },
    {
      "key": "e_1_2_6_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1246/bcsj.68.2125"
    },
    {
      "issue": "2",
      "key": "e_1_2_6_4_2",
      "first-page": "366",
      "volume": "42",
      "author": "Mai H. Z.",
      "year": "2001",
      "journal-title": "Polymer Preprints"
    },
    {
      "key": "e_1_2_6_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1099-0518(20000501)38:9<1673::AID-POLA33>3.0.CO;2-T"
    },
    {
      "key": "e_1_2_6_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0032-3861(00)00889-2"
    },
    {
      "issue": "1",
      "key": "e_1_2_6_7_2",
      "first-page": "526",
      "volume": "43",
      "author": "Mai H. Z.",
      "year": "2002",
      "journal-title": "Polymer Preprints"
    },
    {
      "issue": "1",
      "key": "e_1_2_6_8_2",
      "first-page": "528",
      "volume": "43",
      "author": "Wang Z. Y.",
      "year": "2002",
      "journal-title": "Polymer Preprints"
    },
    {
      "key": "e_1_2_6_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/pol.1979.170170831"
    },
    {
      "key": "e_1_2_6_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1081/DDC-100100328"
    },
    {
      "key": "e_1_2_6_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0378-5173(98)00019-2"
    },
    {
      "key": "e_1_2_6_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/jps.2600690703"
    },
    {
      "key": "e_1_2_6_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.3109/02652049109021862"
    }
  ],
  "container-title": "Journal of Applied Polymer Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fapp.13354",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/app.13354",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        9,
        25
      ]
    ],
    "date-time": "2023-09-25T04:37:45Z",
    "timestamp": 1695616665000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/app.13354"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        12,
        8
      ]
    ]
  },
  "references-count": 12,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2004,
          2,
          15
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/app.13354"
  ],
  "URL": "http://dx.doi.org/10.1002/app.13354",
  "relation": {},
  "ISSN": [
    "0021-8995",
    "1097-4628"
  ],
  "subject": [],
  "container-title-short": "J of Applied Polymer Sci",
  "published": {
    "date-parts": [
      [
        2003,
        12,
        8
      ]
    ]
  }
}