DOI: 10.1002/anr.1780321207. Regulation of human synovial fibroblast collagenase messenger RNA by interleukin‐1

Regulation of human synovial fibroblast collagenase messenger RNA by interleukin‐1

10.1002/anr.1780321207

Crossref journal-article

Wiley

Arthritis & Rheumatism (311)

Abstract

AbstractInterleukin‐1 (IL‐1) may contribute to tissue destruction in rheumatoid arthritis, in part, by inducing messenger RNA (mRNA) that encodes interstitial collagenase. In human synovial fibroblasts in vitro, IL‐1 induced collagenase mRNA accumulation 6 hours after being added to the cells. High levels of mRNA remained present for at least 48 hours after treatment. The rate of transcription of collagenase in isolated nuclei peaked after approximately 6 hours of treatment with IL‐1 and declined thereafter, becoming nearly undetectable by 24 hours. The persistence of mRNA, in view of the transient peak of transcription, suggested that collagenase mRNA was stable in synovial fibroblasts. The half‐life of collagenase mRNA after the synoviocytes were treated with actinomycin D was approximately 27 hours, both in the presence and in the absence of IL‐1. It has been noted that induction of the expression of collagenase by phorbol esters requires fos protein synthesis and is mediated through a tetradecanoyl phorbol acetate response element in the 5′‐flanking region of the gene. However, we found that cycloheximide, when added to synovial fibroblast cultures up to 6 hours after treatment with IL‐1, inhibited the expression of collagenase mRNA. These results suggest that fos alone is unlikely to be sufficient for collagenase expression, and that additional factors, or alternative pathways, are involved in the induction of collagenase by IL‐1.

Bibliography

McCachren, S. S., Greer, P. K., & Niedel, J. E. (1989). Regulation of human synovial fibroblast collagenase messenger RNA by interleukinâ1. Arthritis & Rheumatism, 32(12), 1539â1545. Portico.

Authors 3

S. Spence McCachren (first)
Paula K. Greer (additional)
James E. Niedel (additional)

References 31 Referenced 43

{'key': 'e_1_2_1_2_2', 'first-page': '376', 'article-title': 'Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations', 'volume': '168', 'author': 'Moscatelli DA', 'year': '1985', 'journal-title': 'Exp Cell Res'} / Exp Cell Res / Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations by Moscatelli DA (1985)
10.1016/S0021-9258(17)35859-3 / J Biol Chem / Secretion of metalloproteinases by stimulated capillary endothelial cells by Herron GS (1986)
10.1042/bj1610535 / Biochem J / A latent form of collagenase in the involuting rat uterus and its activation by a serine protease by Woessner JF (1977)
10.1172/JCI106177
{'key': 'e_1_2_1_6_2', 'first-page': '31', 'article-title': 'The mechanisms of cartilage catabolism', 'volume': '18', 'author': 'Dingle JT', 'year': '1986', 'journal-title': 'Agents Actions'} / Agents Actions / The mechanisms of cartilage catabolism by Dingle JT (1986)
{'key': 'e_1_2_1_7_2', 'first-page': '3', 'article-title': 'Biochemical mechanisms of tumor invasion and metastases', 'volume': '256', 'author': 'Liotta LA', 'year': '1988', 'journal-title': 'Prog Clin Biol Res'} / Prog Clin Biol Res / Biochemical mechanisms of tumor invasion and metastases by Liotta LA (1988)
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10.1172/JCI111949
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10.1021/bi00591a005
10.1016/0006-291X(88)90633-X
10.1038/311433a0
{'key': 'e_1_2_1_18_2', 'first-page': '6600', 'article-title': 'Human fibroblast collagenase', 'volume': '261', 'author': 'Goldberg GI', 'year': '1986', 'journal-title': 'J Biol Chem'} / J Biol Chem / Human fibroblast collagenase by Goldberg GI (1986)
10.1073/pnas.83.22.8749
10.4049/jimmunol.140.9.2964 / J Immunol / Exacerbation of arthritis by IL‐1 in rat joints previously injured by peptidoglycan‐polysaccharide by Stimpson SA (1988)
{'key': 'e_1_2_1_21_2', 'first-page': '295', 'article-title': 'Cytokines and the chronic inflammation of rheumatic disease. 1. The presence of interleukin 1 in synovial fluids', 'volume': '55', 'author': 'Nouri AM', 'year': '1984', 'journal-title': 'Clin Exp Immunol'} / Clin Exp Immunol / Cytokines and the chronic inflammation of rheumatic disease. 1. The presence of interleukin 1 in synovial fluids by Nouri AM (1984)
10.1002/art.1780260806
10.1002/art.1780120206
{'key': 'e_1_2_1_24_2', 'volume-title': 'The role of collagenases in joint destruction, The Joints and Synovial Fluid', 'author': 'Harris ED', 'year': '1977'} / The role of collagenases in joint destruction, The Joints and Synovial Fluid by Harris ED (1977)
10.1016/S0021-9258(18)37599-9 / J Biol Chem / Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts by Lindholm D (1988)
10.1021/bi00369a006
10.1016/S0021-9258(18)68705-8 / J Biol Chem / The complete primary structure of human matrix metalloproteinase‐3: identity with stromelysin by Saus J (1988)
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10.1016/0092-8674(87)90612-X
10.1016/0092-8674(88)90195-X
{'key': 'e_1_2_1_32_2', 'first-page': '213', 'article-title': 'Analysis of fos protein complexes and fos related antigens by high resolution two‐dimensional gel electrophoresis', 'volume': '1', 'author': 'Franza BR', 'year': '1987', 'journal-title': 'Oncogene'} / Oncogene / Analysis of fos protein complexes and fos related antigens by high resolution two‐dimensional gel electrophoresis by Franza BR (1987)

Dates

Type	When
Created	18 years, 6 months ago (Feb. 14, 2007, 5:40 p.m.)
Deposited	1 year, 9 months ago (Nov. 23, 2023, 5:05 a.m.)
Indexed	3 months, 1 week ago (May 26, 2025, 9:05 a.m.)
Issued	35 years, 9 months ago (Dec. 1, 1989)
Published	35 years, 9 months ago (Dec. 1, 1989)
Published Online	19 years, 8 months ago (Dec. 14, 2005)
Published Print	35 years, 9 months ago (Dec. 1, 1989)

Funders 0

None

BibTeX

@article{McCachren_1989, title={Regulation of human synovial fibroblast collagenase messenger RNA by interleukin‐1}, volume={32}, ISSN={1529-0131}, url={http://dx.doi.org/10.1002/anr.1780321207}, DOI={10.1002/anr.1780321207}, number={12}, journal={Arthritis & Rheumatism}, publisher={Wiley}, author={McCachren, S. Spence and Greer, Paula K. and Niedel, James E.}, year={1989}, month=dec, pages={1539–1545} }

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