Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
10.1002/anie.199001381
Crossref journal-article
Wiley
Angewandte Chemie International Edition in English (311)
Abstract

AbstractStarburst dendrimers are three‐dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol. Protecting group strategies are crucial in these syntheses, which proceed via discrete “Aufbau” stages referred to as generations. Critical molecular design parameters (CMDPs) such as size, shape, and surface chemistry may be controlled by the reactions and synthetic building blocks used. Starburst dendrimers can mimic certain properties of micelles and liposomes and even those of biomolecules and the still more complicated, but highly organized, building blocks of biological systems. Numerous applications of these compounds are conceivable, particularly in mimicking the functions of large biomolecules as drug carriers and immunogens. This new branch of “supramolecular chemistry” should spark new developments in both organic and macromolecular chemistry.

Bibliography

Tomalia, D. A., Naylor, A. M., & Goddard, W. A. (1990). Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter. Angewandte Chemie International Edition in English, 29(2), 138–175. Portico.

Authors 3
  1. Donald A. Tomalia (first)
  2. Adel M. Naylor (additional)
  3. William A. Goddard (additional)
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Dates
Type When
Created 21 years, 8 months ago (Dec. 30, 2003, 7:03 p.m.)
Deposited 1 year, 10 months ago (Oct. 22, 2023, 6:02 a.m.)
Indexed 4 days, 15 hours ago (Sept. 3, 2025, 6:29 a.m.)
Issued 35 years, 7 months ago (Feb. 1, 1990)
Published 35 years, 7 months ago (Feb. 1, 1990)
Published Online 21 years, 8 months ago (Dec. 22, 2003)
Published Print 35 years, 7 months ago (Feb. 1, 1990)
Funders 0

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@article{Tomalia_1990, title={Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter}, volume={29}, ISSN={0570-0833}, url={http://dx.doi.org/10.1002/anie.199001381}, DOI={10.1002/anie.199001381}, number={2}, journal={Angewandte Chemie International Edition in English}, publisher={Wiley}, author={Tomalia, Donald A. and Naylor, Adel M. and Goddard, William A.}, year={1990}, month=feb, pages={138–175} }