DOI: 10.1002/anie.198101431. Protein Differentiation: Emergence of Novel Proteins during Evolution

Protein Differentiation: Emergence of Novel Proteins during Evolution

10.1002/anie.198101431

Crossref journal-article

Wiley

Angewandte Chemie International Edition in English (311)

Abstract

AbstractThe almost limitless number of proteins can be reduced to approximately 200 basic structures, i.e. geometries of polypeptide chains; these form, the set from which the tracable protein differentiation started. Protein differentiation begins with a gene duplication. One of the gene products is conserved since it must continue to fulfill the original function. The other gene product is conserved as soon as it has taken over a new function. Comparing amino acid sequences of equivalent proteins in two species yields the evolutionary distance between these species, which allows dating of their common ancestor (“molecular palaeontology”). These comparisons are now applied to the geometries of nonequivalent proteins, elucidating the pathways of protein differentiation.

Bibliography

Schulz, G. E. (1981). Protein Differentiation: Emergence of Novel Proteins during Evolution. Angewandte Chemie International Edition in English, 20(2), 143â151. Portico.

Authors 1

Georg E. Schulz (first)

References 50 Referenced 17

{'key': 'e_1_2_1_1_2', 'volume-title': 'Molecular Evolution and Polymorphism', 'author': 'Dickerson R. E.', 'year': '1977'} / Molecular Evolution and Polymorphism by Dickerson R. E. (1977)
{'key': 'e_1_2_1_2_2', 'volume-title': 'Protein Crystallography', 'author': 'Blundell T. L.', 'year': '1976'} / Protein Crystallography by Blundell T. L. (1976)
{'key': 'e_1_2_1_3_2', 'volume-title': 'Atlas of Protein Sequence and Structure', 'author': 'Dayhoff M. O.', 'year': '1978'} / Atlas of Protein Sequence and Structure by Dayhoff M. O. (1978)
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Dates

Type	When
Created	21 years, 8 months ago (Dec. 31, 2003, 10:18 a.m.)
Deposited	1 year, 11 months ago (Oct. 1, 2023, 9:35 p.m.)
Indexed	1 year, 11 months ago (Oct. 2, 2023, 12:27 a.m.)
Issued	44 years, 7 months ago (Feb. 1, 1981)
Published	44 years, 7 months ago (Feb. 1, 1981)
Published Online	21 years, 8 months ago (Dec. 22, 2003)
Published Print	44 years, 7 months ago (Feb. 1, 1981)

Funders 0

None

BibTeX

@article{Schulz_1981, title={Protein Differentiation: Emergence of Novel Proteins during Evolution}, volume={20}, ISSN={0570-0833}, url={http://dx.doi.org/10.1002/anie.198101431}, DOI={10.1002/anie.198101431}, number={2}, journal={Angewandte Chemie International Edition in English}, publisher={Wiley}, author={Schulz, Georg E.}, year={1981}, month=feb, pages={143–151} }

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