DOI: 10.1002/ana.410440324. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

10.1002/ana.410440324

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractRecently, α‐synuclein was shown to be a structural component of the filaments in Lewy bodies (LBs) of Parkinson's disease (PD), dementia with LBs (DLB) as well as the LB variant of Alzheimer's disease, and this suggests that α‐synuclein could play a mechanistic role in the pathogenesis of these disorders. To determine whether α‐synuclein is a building block of inclusions in other neurodegenerative movement disorders, we examined brains from patients with multiple system atrophy (MSA) and detected α‐synuclein, but not β‐ or γ‐synuclein, in glial cytoplasmic inclusions (GCIs) throughout the MSA brain. In MSA white matter, α‐synuclein–positive GCIs were restricted to oligodendrocytes, and α‐synuclein accumulated selectively in MSA white matter with α‐synuclein–positive GCIs. Taken together with evidence that LBs contain insoluble α‐synuclein, our data suggest that a reduction in the solubility of α‐synuclein may induce this protein to form filaments that aggregate into cytoplasmic inclusions, which contribute to the dysfunction or death of glial cells as well as neurons in neurodegenerative disorders with different phenotypes.

Bibliography

Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. âY. (1998). Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble Î±âsynuclein. Annals of Neurology, 44(3), 415â422. Portico.

Authors 10

Pang‐hsien Tu (first)
James E. Galvin (additional)
Minami Baba (additional)
Benoit Giasson (additional)
Taisuke Tomita (additional)
Susan Leight (additional)
Shigeo Nakajo (additional)
Takeshi Iwatsubo (additional)
John Q. Trojanowski (additional)
Virginia M.‐Y. Lee (additional)

References 43 Referenced 564

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Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 10:21 a.m.)
Deposited	1 year, 9 months ago (Oct. 28, 2023, 9:52 a.m.)
Indexed	3 weeks, 1 day ago (July 30, 2025, 11:08 a.m.)
Issued	26 years, 11 months ago (Sept. 1, 1998)
Published	26 years, 11 months ago (Sept. 1, 1998)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	26 years, 11 months ago (Sept. 1, 1998)

Funders 0

None

BibTeX

@article{Tu_1998, title={Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein}, volume={44}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410440324}, DOI={10.1002/ana.410440324}, number={3}, journal={Annals of Neurology}, publisher={Wiley}, author={Tu, Pang‐hsien and Galvin, James E. and Baba, Minami and Giasson, Benoit and Tomita, Taisuke and Leight, Susan and Nakajo, Shigeo and Iwatsubo, Takeshi and Trojanowski, John Q. and Lee, Virginia M.‐Y.}, year={1998}, month=sep, pages={415–422} }

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