DOI: 10.1002/ana.410440108. Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan

Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan

10.1002/ana.410440108

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractTo clarify the alterations of tau, amyloid β protein (Aβ) 1–40 and Aβ1–42(43) in the cerebrospinal fluid (CSF) that accompany normal aging and the progression of Alzheimer's disease (AD), CSF samples of 93 AD patients, 32 longitudinal subjects among these 93 AD patients, 33 patients with non‐AD dementia, 56 with other neurological diseases, and 54 normal control subjects from three independent institutes were analyzed by sensitive enzyme‐linked immunosorbent assays. Although the tau levels increased with aging, a significant elevation of tau and a correlation between the tau levels and the clinical progression were observed in the AD patients. A significant decrease of the Aβ1–42(43) levels and a significant increase of the ratio of Aβ1–40 to Aβ1–42(43) were observed in the AD patients. The longitudinal AD study showed continuous low Aβ1–42(43) levels and an increase of the ratio of Aβ1–40 to Aβ1–42(43) before the onset of AD. These findings suggest that CSF tau may increase with the clinical progression of dementia and that the alteration of the CSF level of Aβ1–42(43) and the ratio of Aβ1–40 to Aβ1–42(43) may start at early stages in AD. The assays of CSF tau, Aβ1–40, and Aβ1–42(43) provided efficient diagnostic sensitivity (71%) and specificity (83%) by using the production of tau levels and the ratio of Aβ1–40 to Aβ1–42(43), and an improvement in sensitivity (to 91%) was obtained in the longitudinal evaluation.

Bibliography

Kanai, M., Matsubara, E., Isoe, K., Urakami, K., Nakashima, K., Arai, H., Sasaki, H., Abe, K., Iwatsubo, T., Kosaka, T., Watanabe, M., Tomidokoro, Y., Shizuka, M., Mizushima, K., Nakamura, T., Igeta, Y., Ikeda, Y., Amari, M., Kawarabayashi, T., â¦ Shoji, M. (1998). Longitudinal study of cerebrospinal fluid levels of tau, AÎ²1â40, and AÎ²1â42(43) in Alzheimerâs disease: A study in Japan. Annals of Neurology, 44(1), 17â26. Portico.

Authors 25

M. Kanai (first)
E. Matsubara (additional)
K. Isoe (additional)
K. Urakami (additional)
K. Nakashima (additional)
H. Arai (additional)
H. Sasaki (additional)
K. Abe (additional)
T. Iwatsubo (additional)
T. Kosaka (additional)
M. Watanabe (additional)
Y. Tomidokoro (additional)
M. Shizuka (additional)
K. Mizushima (additional)
T. Nakamura (additional)
Y. Igeta (additional)
Y. Ikeda (additional)
M. Amari (additional)
T. Kawarabayashi (additional)
K. Ishiguro (additional)
Y. Harigaya (additional)
K. Wakabayashi (additional)
K. Okamoto (additional)
S. Hirai (additional)
M. Shoji (additional)

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10.1002/ana.410370325

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 10:17 a.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 11:38 a.m.)
Indexed	2 months, 1 week ago (June 26, 2025, 2:24 p.m.)
Issued	27 years, 2 months ago (July 1, 1998)
Published	27 years, 2 months ago (July 1, 1998)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	27 years, 2 months ago (July 1, 1998)

Funders 0

None

BibTeX

@article{Kanai_1998, title={Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer’s disease: A study in Japan}, volume={44}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410440108}, DOI={10.1002/ana.410440108}, number={1}, journal={Annals of Neurology}, publisher={Wiley}, author={Kanai, M. and Matsubara, E. and Isoe, K. and Urakami, K. and Nakashima, K. and Arai, H. and Sasaki, H. and Abe, K. and Iwatsubo, T. and Kosaka, T. and Watanabe, M. and Tomidokoro, Y. and Shizuka, M. and Mizushima, K. and Nakamura, T. and Igeta, Y. and Ikeda, Y. and Amari, M. and Kawarabayashi, T. and Ishiguro, K. and Harigaya, Y. and Wakabayashi, K. and Okamoto, K. and Hirai, S. and Shoji, M.}, year={1998}, month=jul, pages={17–26} }

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