DOI: 10.1002/ana.410400204. Neurodegenerative disorders with extensive tau pathology: A comparative study and review

Neurodegenerative disorders with extensive tau pathology: A comparative study and review

10.1002/ana.410400204

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractMany neurodegenerative disorders with onset in mid to late adult life present diagnostic challenges to clinicians and pathologists alike. A distinguishing neuropathological feature has traditionally been the presence or absence of neurofibrillary tangles. Recent biochemical and molecular biological studies have identified the microtubule‐binding protein tau as the predominant component of these and related inclusions, and have provided powerful new reagents for the study of neurodegenerative diseases. Several diseases previously considered distinct pathophysiological entities contain similar tau‐immunoreactive lesions, but qualitative and regional anatomical differences in vulnerability can differentiate the disorders. Comparison of tau‐immunoreactive lesions in three relatively uncommon neurodegenerative diseases—progressive supranuclear palsy, Pick's disease, and corticobasal degeneration—illustrates the types of analyses that demonstrate unexpeceted pathological similarities, but also fundamental differences between these disorders. These results have important implications for the differential diagnosis of disorders containing tau‐immunoreactive lesions, including Alzheimer's disease.

Bibliography

Feany, M. B., & Dickson, D. W. (1996). Neurodegenerative disorders with extensive tau pathology: A comparative study and review. Annals of Neurology, 40(2), 139â148. Portico.

Authors 2

Mel B. Feany (first)
Dennis W. Dickson (additional)

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Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 9:47 a.m.)
Deposited	1 year, 9 months ago (Oct. 26, 2023, 9:24 p.m.)
Indexed	1 month, 1 week ago (July 16, 2025, 9:42 a.m.)
Issued	29 years ago (Aug. 1, 1996)
Published	29 years ago (Aug. 1, 1996)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	29 years ago (Aug. 1, 1996)

Funders 0

None

BibTeX

@article{Feany_1996, title={Neurodegenerative disorders with extensive tau pathology: A comparative study and review}, volume={40}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410400204}, DOI={10.1002/ana.410400204}, number={2}, journal={Annals of Neurology}, publisher={Wiley}, author={Feany, Mel B. and Dickson, Dennis W.}, year={1996}, month=aug, pages={139–148} }

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