DOI: 10.1002/ana.410380413. Reduction of β‐amyloid peptide<sub>42</sub> in the cerebrospinal fluid of patients with Alzheimer's disease

Reduction of β‐amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease

10.1002/ana.410380413

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractIn this clinical study, the cerebrospinal fluid (CSF) level of a Novemberel form of the β‐amyloid peptide (Aβ) extending to position 42 (Aβ42) was determined in patients with Alzheimer's disease (AD) as well as controls. In addition to measurement of CSF Aβ42 levels, total Aβ peptides, microtubule‐associated protein τ, and apolipoprotein E (ApoE) genotype were also assessed. It is interesting that CSF Aβ42 levels were found to be significantly lower in AD patients relative to controls, whereas total Aβ levels were not. Aβ42 has recently been shown to preferentially deposit in the brain tissue of patients with AD, suggesting that diminished clearance may account for its reduction in CSF. As previously reported, τ levels were increased in AD patients; however, neither Aβ42 nor τ levels were apparently influenced by the ApoE genotype.

Bibliography

Motter, R., VigoâPelfrey, C., Kholodenko, D., Barbour, R., JohnsonâWood, K., Galasko, D., Chang, L., Miller, B., Clark, C., Green, R., Olson, D., Southwick, P., Wolfert, R., Munroe, B., Lieberburg, I., Seubert, P., & Schenk, D. (1995). Reduction of Î²âamyloid peptide42 in the cerebrospinal fluid of patients with Alzheimerâs disease. Annals of Neurology, 38(4), 643â648. Portico.

Authors 17

R. Motter (first)
C. Vigo‐Pelfrey (additional)
D. Kholodenko (additional)
R. Barbour (additional)
K. Johnson‐Wood (additional)
D. Galasko (additional)
L. Chang (additional)
B. Miller (additional)
C. Clark (additional)
R. Green (additional)
D. Olson (additional)
P. Southwick (additional)
R. Wolfert (additional)
B. Munroe (additional)
I. Lieberburg (additional)
P. Seubert (additional)
D. Schenk (additional)

References 25 Referenced 528

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10.1111/j.1471-4159.1993.tb09823.x
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10.1016/0896-6273(94)90458-8
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Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 11:27 a.m.)
Deposited	1 year, 10 months ago (Oct. 26, 2023, 2:06 p.m.)
Indexed	1 day, 8 hours ago (Sept. 2, 2025, 6:37 a.m.)
Issued	29 years, 11 months ago (Oct. 1, 1995)
Published	29 years, 11 months ago (Oct. 1, 1995)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	29 years, 11 months ago (Oct. 1, 1995)

Funders 0

None

BibTeX

@article{Motter_1995, title={Reduction of β‐amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer’s disease}, volume={38}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410380413}, DOI={10.1002/ana.410380413}, number={4}, journal={Annals of Neurology}, publisher={Wiley}, author={Motter, R. and Vigo‐Pelfrey, C. and Kholodenko, D. and Barbour, R. and Johnson‐Wood, K. and Galasko, D. and Chang, L. and Miller, B. and Clark, C. and Green, R. and Olson, D. and Southwick, P. and Wolfert, R. and Munroe, B. and Lieberburg, I. and Seubert, P. and Schenk, D.}, year={1995}, month=oct, pages={643–648} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>In this clinical study, the cerebrospinal fluid (CSF) level of a Novemberel form of the \u03b2\u2010amyloid peptide (A\u03b2) extending to position 42 (A\u03b2<jats:sub>42</jats:sub>) was determined in patients with Alzheimer's disease (AD) as well as controls. In addition to measurement of CSF A\u03b2<jats:sub>42</jats:sub> levels, total A\u03b2 peptides, microtubule\u2010associated protein \u03c4, and apolipoprotein E (ApoE) genotype were also assessed. It is interesting that CSF A\u03b2<jats:sub>42</jats:sub> levels were found to be significantly lower in AD patients relative to controls, whereas total A\u03b2 levels were not. A\u03b2<jats:sub>42</jats:sub> has recently been shown to preferentially deposit in the brain tissue of patients with AD, suggesting that diminished clearance may account for its reduction in CSF. As previously reported, \u03c4 levels were increased in AD patients; however, neither A\u03b2<jats:sub>42</jats:sub> nor \u03c4 levels were apparently influenced by the ApoE genotype.</jats:p>",
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