DOI: 10.1002/ana.410330406. Association of a monoamine oxidase B allele with Parkinson's disease

Association of a monoamine oxidase B allele with Parkinson's disease

10.1002/ana.410330406

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractMonoamine oxidase B(MAO‐B) is implicated in the cause of Parkinson's disease(PD) because of its role in metabolizing the neurotoxin 1‐methyl–4‐phenyl–1,2,3,6‐tetrahydropyridine, and forming H2O2 during dopamine metabolism. Altered MAO‐B activity has been observed in PD platelets. Polymerase chain reaction was used to amplify a portion of the MAO‐B gene. Polymerase chain reaction products were screened with restriction enzymes to identify fragments useful for single‐stranded conformational polymorphism analysis. A single‐stranded conformational polymorphism was identified in an MAO‐B polymerase chain reaction product after Hae III digestion. One hundred twenty‐one control individuals were allelotyped with frequencies of 0.45 and 0.55 for alleles 1 and 2, respectively. Frequencies of 0.62 and 0.38 (1 and 2, respectively) were observed in a population of 46 patients with PD. The presence of MAO‐B allele 1 is associated with a relative risk for PD of 2.03‐fold (confidence interval, 1.44–2.61; p < 0.02). For comparison, a monoamine oxidase A polymorphism was used to determine allelic frequencies in these same populations and no statistically significant differences were found. These results suggest that an inherited variant of MAO‐B may be involved in a genetic predisposition for PD.

Bibliography

Kurth, J. H., Kurth, M. C., Poduslo, S. E., & Schwankhaus, J. D. (1993). Association of a monoamine oxidase B allele with Parkinsonâs disease. Annals of Neurology, 33(4), 368â372. Portico.

Authors 4

Janice H. Kurth (first)
Matthias C. Kurth (additional)
Shirley E. Poduslo (additional)
John D. Schwankhaus (additional)

References 32 Referenced 122

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Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 9:37 a.m.)
Deposited	1 year, 10 months ago (Oct. 25, 2023, 6:02 p.m.)
Indexed	1 week, 2 days ago (Aug. 27, 2025, 11:43 a.m.)
Issued	32 years, 5 months ago (April 1, 1993)
Published	32 years, 5 months ago (April 1, 1993)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	32 years, 5 months ago (April 1, 1993)

Funders 0

None

BibTeX

@article{Kurth_1993, title={Association of a monoamine oxidase B allele with Parkinson’s disease}, volume={33}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410330406}, DOI={10.1002/ana.410330406}, number={4}, journal={Annals of Neurology}, publisher={Wiley}, author={Kurth, Janice H. and Kurth, Matthias C. and Poduslo, Shirley E. and Schwankhaus, John D.}, year={1993}, month=apr, pages={368–372} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>Monoamine oxidase B(MAO\u2010B) is implicated in the cause of Parkinson's disease(PD) because of its role in metabolizing the neurotoxin 1\u2010methyl\u20134\u2010phenyl\u20131,2,3,6\u2010tetrahydropyridine, and forming H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> during dopamine metabolism. Altered MAO\u2010B activity has been observed in PD platelets. Polymerase chain reaction was used to amplify a portion of the MAO\u2010B gene. Polymerase chain reaction products were screened with restriction enzymes to identify fragments useful for single\u2010stranded conformational polymorphism analysis. A single\u2010stranded conformational polymorphism was identified in an MAO\u2010B polymerase chain reaction product after <jats:italic>Hae</jats:italic> III digestion. One hundred twenty\u2010one control individuals were allelotyped with frequencies of 0.45 and 0.55 for alleles 1 and 2, respectively. Frequencies of 0.62 and 0.38 (1 and 2, respectively) were observed in a population of 46 patients with PD. The presence of MAO\u2010B allele 1 is associated with a relative risk for PD of 2.03\u2010fold (confidence interval, 1.44\u20132.61; <jats:italic>p</jats:italic> &lt; 0.02). For comparison, a monoamine oxidase A polymorphism was used to determine allelic frequencies in these same populations and no statistically significant differences were found. These results suggest that an inherited variant of MAO\u2010B may be involved in a genetic predisposition for PD.</jats:p>",
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