DOI: 10.1002/ana.410250520. Swellings of proximal axons in a case of motor neuron disease

Swellings of proximal axons in a case of motor neuron disease

10.1002/ana.410250520

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractSerial semithin sections of lumbar anterior horn cells from a patient with rapidly progressive sporadic motor neuron disease were searched for direct connections between swellings of neuronal processes and perikarya. Focal swellings of the proximal axons were not uncommonly seen to be connected directly to perikarya. These swellings varied in shape and size and some were identified as spheroids. Most of the cell bodies connected with swellings showed otherwise normal architecture. These observations suggest that the focal swellings of proximal axons, particularly the distal portion of the initial segment and the first internode of the myelinated axon, indicate an early pathological change, and may represent functionally and morphologically vulnerable sites.

Bibliography

Sasaki, S., Maruyama, S., Yamane, K., Sakuma, H., & Takeishi, M. (1989). Swellings of proximal axons in a case of motor neuron disease. Annals of Neurology, 25(5), 520â522. Portico.

Authors 5

Shoichi Sasaki (first)
Shoichi Maruyama (additional)
Kiyomi Yamane (additional)
Hideo Sakuma (additional)
Makoto Takeishi (additional)

References 9 Referenced 33

10.1212/WNL.38.7.1114
{'key': 'e_1_2_1_3_2', 'first-page': '87', 'article-title': 'Observation of the proximal axons of large anterior horn cells in the human spinal cord embedded in Epon with toluidine blue staining', 'volume': '8', 'author': 'Sasaki S', 'year': '1987', 'journal-title': 'Neuropathology'} / Neuropathology / Observation of the proximal axons of large anterior horn cells in the human spinal cord embedded in Epon with toluidine blue staining by Sasaki S (1987)
10.1212/WNL.18.9.841
{'key': 'e_1_2_1_5_2', 'first-page': '448', 'article-title': "Early pathological changes of amyotrophic lateral sclerosis. Autopsy findings of a case of 10 months' duration", 'volume': '11', 'author': 'Inoue K', 'year': '1979', 'journal-title': 'Neurol Med'} / Neurol Med / Early pathological changes of amyotrophic lateral sclerosis. Autopsy findings of a case of 10 months' duration by Inoue K (1979)
{'key': 'e_1_2_1_6_2', 'first-page': '148', 'article-title': 'Early pathological changes of amyotrophic lateral sclerosis. Electron microscopic study of chromatolysis, spheroids and Bunina bodies', 'volume': '13', 'author': 'Hirano A', 'year': '1980', 'journal-title': 'Neurol Med'} / Neurol Med / Early pathological changes of amyotrophic lateral sclerosis. Electron microscopic study of chromatolysis, spheroids and Bunina bodies by Hirano A (1980)
10.1007/BF00688453
{'key': 'e_1_2_1_8_2', 'first-page': '161', 'volume-title': 'Experimental and clinical neurotoxicology', 'author': 'Griffin JW', 'year': '1980'} / Experimental and clinical neurotoxicology by Griffin JW (1980)
10.1002/ana.410120312
{'key': 'e_1_2_1_10_2', 'first-page': '89', 'article-title': 'Pathology of motor neurons in accelerated hereditary canine spinal muscular atrophy', 'volume': '46', 'author': 'Cork LC', 'year': '1982', 'journal-title': 'Lab Invest'} / Lab Invest / Pathology of motor neurons in accelerated hereditary canine spinal muscular atrophy by Cork LC (1982)

Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 9:11 a.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 11:32 p.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 2:46 p.m.)
Issued	36 years, 3 months ago (May 1, 1989)
Published	36 years, 3 months ago (May 1, 1989)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	36 years, 3 months ago (May 1, 1989)

Funders 0

None

BibTeX

@article{Sasaki_1989, title={Swellings of proximal axons in a case of motor neuron disease}, volume={25}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410250520}, DOI={10.1002/ana.410250520}, number={5}, journal={Annals of Neurology}, publisher={Wiley}, author={Sasaki, Shoichi and Maruyama, Shoichi and Yamane, Kiyomi and Sakuma, Hideo and Takeishi, Makoto}, year={1989}, month=may, pages={520–522} }

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