DOI: 10.1002/ana.410190613. Increased leukotriene C<sub>4</sub> and vasogenic edema surrounding brain tumors in humans

Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans

10.1002/ana.410190613

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractLeukotrines are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene–like immunoreactivity was increased in intracranial tumors associated with peritumoral edema. In 20 patients undergoing craniotomy tissue specimens were immediately frozen after removal and tissue leukotriene C4 levels were determined by radioimmunoassay. An index of peritumoral edema was estimated from preoperative contrast‐enhanced computed tomographic scans. There was a significant correlation between brain edema and tissue leukotriene levels (p < 0.003). Metastatic tumors (n = 8) had the highest leukotriene C4 level at 13.8 ± 8.5 pg/mg tissue (mean ± SE) and the highest index of edema 5.7 ± 1.8. The mean leukotriene C4 level in the gliomas (n + 5) ws 6.2 ± 2.3 pg/mg tissue and the edema index was 2.1 ± 0.6. There was no edema and no neoplasma in he temporal lobes removed for seizure (n + 2), and their level of leukotriene C4 was 0.4 ± 0.1 pg/mg tissue. The formation of leukotriene C4 is stimulated by intracranial tumors. Leukotrienes increase blood–brain barrier permeability and may be important in the formation of vasogenic edema surrounding tumors.

Bibliography

Black, K. L., Hoff, J. T., McGillicuddy, J. E., & Gebarski, S. S. (1986). Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans. Annals of Neurology, 19(6), 592â595. Portico.

Authors 4

Keith L. Black (first)
Julian T. Hoff (additional)
John E. McGillicuddy (additional)
Stephen S. Gebarski (additional)

References 19 Referenced 107

{'key': 'e_1_2_1_2_2', 'first-page': '63', 'article-title': 'Oxygen free radicals and leukotriene B4 induce increase in vascular leakage is mediated by polymorphonuclear leukocytes', 'volume': '7', 'author': 'Bjork J', 'year': '1982', 'journal-title': 'Agents Actions'} / Agents Actions / Oxygen free radicals and leukotriene B4 induce increase in vascular leakage is mediated by polymorphonuclear leukocytes by Bjork J (1982)
10.1016/0262-1746(84)90117-3
10.1002/ana.410180313
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10.1038/287147a0
10.1002/ana.410130608
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10.1126/science.6808665
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10.1126/science.6301011
{'key': 'e_1_2_1_15_2', 'volume-title': 'Leukotrienes and Other Lipoxygenase Products', 'author': 'Samuelsson B', 'year': '1982'} / Leukotrienes and Other Lipoxygenase Products by Samuelsson B (1982)
10.1016/0006-291X(79)92146-6
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10.1016/0262-1746(83)90041-0
10.1016/0090-6980(81)90012-5
10.3171/jns.1983.59.4.0612

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 12:31 p.m.)
Deposited	1 year, 10 months ago (Oct. 21, 2023, 3:17 p.m.)
Indexed	2 months, 3 weeks ago (June 11, 2025, 5:28 a.m.)
Issued	39 years, 3 months ago (June 1, 1986)
Published	39 years, 3 months ago (June 1, 1986)
Published Online	20 years, 10 months ago (Oct. 8, 2004)
Published Print	39 years, 3 months ago (June 1, 1986)

Funders 0

None

BibTeX

@article{Black_1986, title={Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans}, volume={19}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410190613}, DOI={10.1002/ana.410190613}, number={6}, journal={Annals of Neurology}, publisher={Wiley}, author={Black, Keith L. and Hoff, Julian T. and McGillicuddy, John E. and Gebarski, Stephen S.}, year={1986}, month=jun, pages={592–595} }

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  "abstract": "<jats:title>Abstract</jats:title><jats:p>Leukotrines are pharmacologically active compounds that promote vascular permeability. In this study we sought to determine whether tissue leukotriene\u2013like immunoreactivity was increased in intracranial tumors associated with peritumoral edema. In 20 patients undergoing craniotomy tissue specimens were immediately frozen after removal and tissue leukotriene C<jats:sub>4</jats:sub> levels were determined by radioimmunoassay. An index of peritumoral edema was estimated from preoperative contrast\u2010enhanced computed tomographic scans. There was a significant correlation between brain edema and tissue leukotriene levels (<jats:italic>p</jats:italic> &lt; 0.003). Metastatic tumors (n = 8) had the highest leukotriene C<jats:sub>4</jats:sub> level at 13.8 \u00b1 8.5 pg/mg tissue (mean \u00b1 SE) and the highest index of edema 5.7 \u00b1 1.8. The mean leukotriene C<jats:sub>4</jats:sub> level in the gliomas (n + 5) ws 6.2 \u00b1 2.3 pg/mg tissue and the edema index was 2.1 \u00b1 0.6. There was no edema and no neoplasma in he temporal lobes removed for seizure (n + 2), and their level of leukotriene C<jats:sub>4</jats:sub> was 0.4 \u00b1 0.1 pg/mg tissue. The formation of leukotriene C<jats:sub>4</jats:sub> is stimulated by intracranial tumors. Leukotrienes increase blood\u2013brain barrier permeability and may be important in the formation of vasogenic edema surrounding tumors.</jats:p>",
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