DOI: 10.1002/ana.410170310. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

10.1002/ana.410170310

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractOne hundred brains of patients with Down's syndrome(DS) who died in insstitutions for chronic care were exemined for clinicopathological correlation of Alzheimer's disease. Fifty‐one were below and 49 were above age 30 years at death. Tissues from the right, prefrontal, and hippocampal cortices were processed for microscopy using H & E and Bodian‐periodic acid‐schiff impregnation. M orphometric evluations of plaques and tangles were carried out Plaques or plaques and tangles were found in the brains of 56 patients with DS, 7 below age 30 and 49 above the age of 30. The brains of the patients with DS who also had clinical dementia had more than twenty plaques or plaques and tangles per 1.5 × 106 μm2 of cortex. The numbers of plaques and tangles found in the brains of the patients with DS above the age of 30 greatly increased with age but varied from brain to brain. These observations suggest a coreelation among dementia, the density of plaques and tangles, and age. All 100 brains studied showed early arrest of brain growth and brain atrophy, a condition that may have been due to prenatal arrest of neurogenesis mainly in the granular cell layers, prenatal and postnatal arrest of synaptogenesis, and early aging. Plaques and tangles developed twenty to thirty years earlier and dementia was clinically detected at least three times more frequently (20 to 30%) in DS than it is known to occur in the non‐DS population.

Bibliography

Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985). Occurrence of neuropathological changes and dementia of Alzheimerâs disease in Downâs syndrome. Annals of Neurology, 17(3), 278â282. Portico.

Authors 3

K. E. Wisniewski (first)
H. M. Wisniewski (additional)
G. Y. Wen (additional)

References 36 Referenced 908

10.1097/00005072-198305000-00066
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{'key': 'e_1_2_1_6_2', 'volume-title': 'Mental Illness and the Aging Brain', 'author': 'Corselis YAN', 'year': '1962'} / Mental Illness and the Aging Brain by Corselis YAN (1962)
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{'key': 'e_1_2_1_36_2', 'first-page': '319', 'volume-title': "Textbook of Alztheimer's Disease", 'author': 'Wisniewski KE', 'year': '1983'} / Textbook of Alztheimer's Disease by Wisniewski KE (1983)
10.1097/00005072-198305000-00114

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 12:21 p.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 9:54 p.m.)
Indexed	1 day, 7 hours ago (Sept. 4, 2025, 10 a.m.)
Issued	40 years, 6 months ago (March 1, 1985)
Published	40 years, 6 months ago (March 1, 1985)
Published Online	20 years, 10 months ago (Oct. 7, 2004)
Published Print	40 years, 6 months ago (March 1, 1985)

Funders 0

None

BibTeX

@article{Wisniewski_1985, title={Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome}, volume={17}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410170310}, DOI={10.1002/ana.410170310}, number={3}, journal={Annals of Neurology}, publisher={Wiley}, author={Wisniewski, K. E. and Wisniewski, H. M. and Wen, G. Y.}, year={1985}, month=mar, pages={278–282} }

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