DOI: 10.1002/ana.410170309. Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type

Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type

10.1002/ana.410170309

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractSenile plaques (SP) and neurofibrillary tangles (NFT) were found in 38 (74.5%) of 51 unselected brains of nondemented patients who died between the ages of 55 and 64 years. A high proportion (22, or 43%) had only NFTs. These were consistently present in the entorhinal cortex and/or the hippocampus; the olfactory bulb, the amygdala, and the nucleus basalis of Meynert were also occasionally invloved. Isolated SPs were seen in only 3 brains (6%); SPs and NFTs coexisted in 13 (25.5%). The distribution patterns of NFTs and SPs occurred in a more generalized distribution over the base and convexity of the cerebrum. The plaques were usually small (30 μ in diameter) and consisted of delicate fibrillary material. Other types of SP were also seen. The incidence of various types of plaques in nondemented patients is considered to indicate a morphological evolution of these structures.

Bibliography

Ulrich, J. (1985). Alzheimer changes in nondemented patients younger than sixtyâfive: Possible early stages of Alzheimerâs disease and senile dementia of Alzheimer type. Annals of Neurology, 17(3), 273â277. Portico.

Authors 1

J. Ulrich (first)

References 39 Referenced 181

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{'key': 'e_1_2_1_5_2', 'first-page': '457', 'article-title': "The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome", 'volume': '73', 'author': 'Bruger PC', 'year': '1973', 'journal-title': 'Am J Pathol'} / Am J Pathol / The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome by Bruger PC (1973)
{'key': 'e_1_2_1_6_2', 'first-page': '15', 'volume-title': "Alzheimer's Disease: Senile Dementia and Related Disorders (Aging, Vol 7)", 'author': 'Katzman R', 'year': '1978'} / Alzheimer's Disease: Senile Dementia and Related Disorders (Aging, Vol 7) by Katzman R (1978)
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{'key': 'e_1_2_1_32_2', 'first-page': '77', 'article-title': "The fine structure of eosinophilic stages of Alzheimer's neurofibrillary tangles", 'volume': '16', 'author': 'Okamoto K', 'year': '1983', 'journal-title': 'Clin Electron Microscopy'} / Clin Electron Microscopy / The fine structure of eosinophilic stages of Alzheimer's neurofibrillary tangles by Okamoto K (1983)
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Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 12:21 p.m.)
Deposited	1 year, 10 months ago (Oct. 19, 2023, 9:54 p.m.)
Indexed	1 year, 3 months ago (May 17, 2024, 7:24 p.m.)
Issued	40 years, 5 months ago (March 1, 1985)
Published	40 years, 5 months ago (March 1, 1985)
Published Online	20 years, 10 months ago (Oct. 7, 2004)
Published Print	40 years, 5 months ago (March 1, 1985)

Funders 0

None

BibTeX

@article{Ulrich_1985, title={Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer’s disease and senile dementia of Alzheimer type}, volume={17}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410170309}, DOI={10.1002/ana.410170309}, number={3}, journal={Annals of Neurology}, publisher={Wiley}, author={Ulrich, J.}, year={1985}, month=mar, pages={273–277} }

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