DOI: 10.1002/ana.410140616. Lack of clinical efficacy of chronic oral physostigmine in Alzheimer's disease

Lack of clinical efficacy of chronic oral physostigmine in Alzheimer's disease

10.1002/ana.410140616

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractTen patients with mild to severe Alzheimer's disease were treated for up to 10 months with 10 to 15 mg oral physostigmine daily or with placebo, according to a single blind, multiple crossover protocol. No clinically meaningful improvement occurred with physostigmine treatment.

Bibliography

Jotkowitz, S. (1983). Lack of clinical efficacy of chronic oral physostigmine in Alzheimerâs disease. Annals of Neurology, 14(6), 690â691. Portico.

Authors 1

Seymour Jotkowitz (first)

References 8 Referenced 34

10.1192/bjp.114.512.797
{'key': 'e_1_2_1_3_2', 'first-page': '721', 'article-title': 'Memory enhancement with oral physostigmine in Alzheimer disease', 'volume': '308', 'author': 'Davis KL', 'year': '1982', 'journal-title': 'N Engl J Med'} / N Engl J Med / Memory enhancement with oral physostigmine in Alzheimer disease by Davis KL (1982)
10.1016/S0140-6736(76)91936-X
{'key': 'e_1_2_1_5_2', 'first-page': '553', 'article-title': 'Diagnostic criteria for primary neuronal degeneration of the Alzheimer type', 'volume': '2', 'author': 'Eisdorfer C', 'year': '1980', 'journal-title': 'J Fam Pract'} / J Fam Pract / Diagnostic criteria for primary neuronal degeneration of the Alzheimer type by Eisdorfer C (1980)
{'key': 'e_1_2_1_6_2', 'first-page': '15', 'article-title': 'Microchemical pathology of the cerebral cortex in presenile dementia', 'volume': '89', 'author': 'Pope A', 'year': '1965', 'journal-title': 'Trans Am Neurol Assoc'} / Trans Am Neurol Assoc / Microchemical pathology of the cerebral cortex in presenile dementia by Pope A (1965)
{'key': 'e_1_2_1_7_2', 'first-page': '720', 'article-title': 'Memory enhancement with oral physostigmine in Alzheimer disease', 'volume': '308', 'author': 'Thal L', 'year': '1982', 'journal-title': 'N Engl J Med'} / N Engl J Med / Memory enhancement with oral physostigmine in Alzheimer disease by Thal L (1982)
10.1002/ana.410130220
10.1002/ana.410100203

Dates

Type	When
Created	20 years, 8 months ago (Jan. 1, 2005, 12:02 p.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 4 a.m.)
Indexed	1 month, 2 weeks ago (July 19, 2025, 11:51 p.m.)
Issued	41 years, 9 months ago (Dec. 1, 1983)
Published	41 years, 9 months ago (Dec. 1, 1983)
Published Online	20 years, 11 months ago (Oct. 7, 2004)
Published Print	41 years, 9 months ago (Dec. 1, 1983)

Funders 0

None

BibTeX

@article{Jotkowitz_1983, title={Lack of clinical efficacy of chronic oral physostigmine in Alzheimer’s disease}, volume={14}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410140616}, DOI={10.1002/ana.410140616}, number={6}, journal={Annals of Neurology}, publisher={Wiley}, author={Jotkowitz, Seymour}, year={1983}, month=dec, pages={690–691} }

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