DOI: 10.1002/ana.410100605. Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent

Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent

10.1002/ana.410100605

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractMice inoculated intracerebrally with mouse brain homogenate infected with a particular strain of scrapie agent developed amyloid and neuritic plaques and amyloid tubercles along the injection track, solid wall‐like infiltrations at the injection site, or both, Our observations implicate an infectious agent in the localized formation of the amyloid and the neuritic plaque—the leading pathological change found in normal elderly people and animals and in patients with senile dementia of the Alzheimer type. Further, these studies indicate that microglia appear to play a central role in the pathogenesis of amyloid formation and could be involved in the processing, production, and assembly of the fibers.

Bibliography

Wisniewski, H. M., Moretz, R. C., & Lossinsky, A. S. (1981). Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Annals of Neurology, 10(6), 517â522. Portico.

Authors 3

Henryk M. Wisniewski (first)
Roger C. Moretz (additional)
Albert S. Lossinsky (additional)

References 21 Referenced 110

{'key': 'e_1_2_1_2_2', 'first-page': '323', 'volume-title': 'Amyloidosis, Proceedings of the 5th Sigrid Juselius Foundation Symposium', 'author': 'Benditt EP', 'year': '1976'} / Amyloidosis, Proceedings of the 5th Sigrid Juselius Foundation Symposium by Benditt EP (1976)
10.1007/BF00707108
10.1111/j.1365-2990.1976.tb00521.x
10.1111/j.1365-2990.1975.tb00388.x
10.1111/j.1365-2990.1981.tb00100.x
10.1016/0021-9975(79)90029-X
10.1016/0002-9343(79)91050-7
10.1056/NEJM198006053022305
10.1177/16.10.633
10.1001/archneur.1972.00490120070008
10.1007/BF00685304
10.1097/00005072-198005000-00119
{'key': 'e_1_2_1_14_2', 'volume-title': 'The Fine Structure of the Nervous System', 'author': 'Peters A', 'year': '1976'} / The Fine Structure of the Nervous System by Peters A (1976)
10.1007/BF00432582
{'key': 'e_1_2_1_16_2', 'first-page': '1', 'article-title': 'Histochemistry of amyloid: general considerations, light microscopical and ultrastructural examinations', 'volume': '1', 'author': 'Stiller D', 'year': '1975', 'journal-title': 'Exp Pathol Suppl'} / Exp Pathol Suppl / Histochemistry of amyloid: general considerations, light microscopical and ultrastructural examinations by Stiller D (1975)
TerryRD WisniewskiHM:The ultrastructure of the neurofibrillary tangle and the senile plaque. In Wolstenholme GEW O'Connor M (eds): CIBA Foundation Symposium on Alzheimer's Disease and Related Conditions. London Churchill1970 pp145–168 (10.1002/9780470719749.ch10)
VorbrodtAW LossinskyAS WisniewskiHM MoretzRC IwanowskiL: Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice.Acta Neuropathol (Berl)(in press)
{'key': 'e_1_2_1_19_2', 'volume-title': 'Proceedings of the 5th Sigrid Juselius Foundation Symposium', 'author': 'Wegelius O', 'year': '1976'} / Proceedings of the 5th Sigrid Juselius Foundation Symposium by Wegelius O (1976)
10.1126/science.1237933
{'key': 'e_1_2_1_21_2', 'first-page': '1', 'article-title': 'Re‐examination of the pathogenesis of the senile plaque', 'volume': '2', 'author': 'Wisniewski HW', 'year': '1973', 'journal-title': 'Prog Neuropathol'} / Prog Neuropathol / Re‐examination of the pathogenesis of the senile plaque by Wisniewski HW (1973)
10.1097/00005072-198105000-00137

Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 8:20 a.m.)
Deposited	1 year, 9 months ago (Nov. 2, 2023, 2:41 a.m.)
Indexed	2 weeks, 1 day ago (Aug. 7, 2025, 4:46 p.m.)
Issued	43 years, 8 months ago (Dec. 1, 1981)
Published	43 years, 8 months ago (Dec. 1, 1981)
Published Online	20 years, 10 months ago (Oct. 7, 2004)
Published Print	43 years, 8 months ago (Dec. 1, 1981)

Funders 0

None

BibTeX

@article{Wisniewski_1981, title={Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent}, volume={10}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410100605}, DOI={10.1002/ana.410100605}, number={6}, journal={Annals of Neurology}, publisher={Wiley}, author={Wisniewski, Henryk M. and Moretz, Roger C. and Lossinsky, Albert S.}, year={1981}, month=dec, pages={517–522} }

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