DOI: 10.1002/ana.410030606. Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculation

Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculation

10.1002/ana.410030606

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractMetabolite levels were measured in seven brain regions in cats after 15 or 30 minutes of a severe ischemic insult and after a 90‐minute period of recirculation following 15 or 30 minutes of ischemia. Brain levels of phosphocreatine were depleted after a 15‐ or 30‐minute insult, and lactate levels were extremely high at both times. The adenosine triphosphate (ATP) content in many brain areas and the presence of microregions of low reduced nicotinamineadenine dinucleotide in the brains of the animals that had 15 minutes of ischemia suggested that the ischemia, though severe, was not complete.Recirculation following a 15‐minute insult restored brain levels of ATP and phosphocreatine to 70 to 100% of control values in all regions analyzed. In contrast, metabolic recovery from a 30‐minute insult was regionally heterogeneous. Thus, there was persistent depression of ATP and phosphocreatine and elevation of lactate, which was localized in discrete cortical foci near the longitudinal midline. The factors governing the localization of metabolic failure must have become manifest during the recirculation period since the ischemic insult itself caused similar metabolic perturbations in all cortical regions.

Bibliography

Welsh, F. A., Ginsberg, M. D., Rieder, W., & Budd, W. W. (1978). Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculation. Annals of Neurology, 3(6), 493â501. Portico.

Authors 4

Frank A. Welsh (first)
Myron D. Ginsberg (additional)
Wendy Rieder (additional)
William W. Budd (additional)

References 18 Referenced 44

10.1021/bi00851a033
10.1016/0006-8993(69)90144-9
GinsbergMD BuddWW WelshFA: Diffuse cerebral ischemia in the cat: I. Local blood flow during severe ischemia and recirculation.Ann Neurol p482this issue (10.1002/ana.410030605)
10.1001/archneur.1973.00490300037004
10.1016/0003-2697(73)90409-0
10.1136/jnnp.38.12.1197
10.1111/j.1471-4159.1977.tb07709.x
10.1016/0006-8993(74)91050-6
{'key': 'e_1_2_1_10_2', 'volume-title': 'A Flexible System of Enzymatic Analysis', 'author': 'Lowry OH', 'year': '1972'} / A Flexible System of Enzymatic Analysis by Lowry OH (1972)
10.3171/jns.1975.43.3.0318
10.3171/jns.1975.43.3.0323
NordströmC‐H:Effects of phenobarbital in cerebral ischemia. PhD Thesis Lund Sweden 1971
10.1001/archneur.1973.00490280046006
{'key': 'e_1_2_1_15_2', 'first-page': '217', 'article-title': 'Graded hypoxia‐oligemia in rat brain. I. Biochemical alterations and their implications', 'volume': '29', 'author': 'Salford LG', 'year': '1973', 'journal-title': 'Arch Neurol'} / Arch Neurol / Graded hypoxia‐oligemia in rat brain. I. Biochemical alterations and their implications by Salford LG (1973)
10.1111/j.1471-4159.1977.tb07710.x
10.1126/science.201026
10.1007/978-1-4615-9035-4_23
WelshFA RiederW: Evaluation ofin situfreezing of cat brain by NADH fluorescence.J Neurochem(in press)

Dates

Type	When
Created	20 years, 7 months ago (Jan. 1, 2005, 11:44 a.m.)
Deposited	1 year, 9 months ago (Nov. 2, 2023, 12:20 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 12, 2024, 1:55 p.m.)
Issued	47 years, 2 months ago (June 1, 1978)
Published	47 years, 2 months ago (June 1, 1978)
Published Online	20 years, 10 months ago (Oct. 7, 2004)
Published Print	47 years, 2 months ago (June 1, 1978)

Funders 0

None

BibTeX

@article{Welsh_1978, title={Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculation}, volume={3}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410030606}, DOI={10.1002/ana.410030606}, number={6}, journal={Annals of Neurology}, publisher={Wiley}, author={Welsh, Frank A. and Ginsberg, Myron D. and Rieder, Wendy and Budd, William W.}, year={1978}, month=jun, pages={493–501} }

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