DOI: 10.1002/ana.410030203. What hope for repair of the brain?

10.1002/ana.410030203

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractThe consequences of axonal injuries in the adult nervous system depend on the location of the axons: complete anatomical and functional repair can occur in the peripheral but not the central nervous sytem. A quantitative electron microscopical comparison of the reactions to axonal injuries in a peripheral site (the superior cervical sympathetic ganglion) and in a central site (the septal nuclei) in adult rats shows that in both cases the denervated postsynaptic sites are reinnervated by new formation of synapses. However, in the ganglion it is the originally severed axons which form the new synapses (regeneration), whereas in the septum the new synapses arise from local, undamaged axons and the cut axons do not reestablish their original contacts. Failure of regeneration in the central site is probably due to the fact that the growing axon sprouts are incapable of finding a pathway to the denervated tissues. Since the observations indicate that the neuropil of the central nervous system is capable of highly efficient synapse formation after injury, true repair of central nervous sytem damage might be possible if methods could be devised for dealing with the “pathway” problem.

Bibliography

Raisman, G. (1978). What hope for repair of the brain? Annals of Neurology, 3(2), 101â106. Portico.

Authors 1

Geoffrey Raisman (first)

References 12 Referenced 22

{'key': 'e_1_2_1_2_2', 'first-page': '723', 'volume-title': 'The Neurosciences: A Study Program', 'author': 'Altman J', 'year': '1967'} / The Neurosciences: A Study Program by Altman J (1967)
BarberPC RaismanG: Replacement of receptor neurons after section of the vomeronasal nerves in the adult mouse.Brain Res(in press)
{'key': 'e_1_2_1_4_2', 'volume-title': 'Degeneration and Regeneration of the Nervous System', 'author': 'Cajal S', 'year': '1928'} / Degeneration and Regeneration of the Nervous System by Cajal S (1928)
10.1083/jcb.59.2.525
10.1002/cne.901700304
10.1098/rstb.1977.0050
10.1113/jphysiol.1897.sp000688
10.1016/0006-8993(76)90137-2
10.1098/rstb.1977.0047
10.1016/0006-8993(73)90729-4
10.1016/0006-8993(73)90030-9
10.1016/0006-8993(74)90187-5

Dates

Type	When
Created	20 years, 8 months ago (Dec. 31, 2004, 5:50 p.m.)
Deposited	1 year, 10 months ago (Nov. 2, 2023, 2:58 a.m.)
Indexed	1 year, 3 months ago (May 17, 2024, 8:58 p.m.)
Issued	47 years, 7 months ago (Feb. 1, 1978)
Published	47 years, 7 months ago (Feb. 1, 1978)
Published Online	20 years, 10 months ago (Oct. 7, 2004)
Published Print	47 years, 7 months ago (Feb. 1, 1978)

Funders 0

None

BibTeX

@article{Raisman_1978, title={What hope for repair of the brain?}, volume={3}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410030203}, DOI={10.1002/ana.410030203}, number={2}, journal={Annals of Neurology}, publisher={Wiley}, author={Raisman, Geoffrey}, year={1978}, month=feb, pages={101–106} }

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