DOI: 10.1002/ana.410010603. Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil

Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil

10.1002/ana.410010603

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractFollowing periods of bilateral cerebral ischemia in urethane‐anesthetized Mongolian gerbils, the metabolism of isolated brain mitochondria was assessed in an in vitro oxygenated medium in the presence of the substrates glutamate‐malate. Mitochondria from both control and ischemic brains were well coupled. Urethane‐anesthetized controls showed an early mild depression and a subsequent enhancement of State 3 respiration (ADP present) relative to awake controls. Respiratory activity in State 3, calculated per mol of cytochrome oxidase, was first depressed below control values following 60 minutes of ischemia; and a further decline, to 46 to 58% of control values, followed 90 to 120 minutes of ischemia. Mitochondrial calcium ion accumulation was depressed by ischemia of 2 hours in moribund animals. In contrast, a significant degree of cerebral edema was observed with ischemia of only 30 minutes' duration. Respiration of brain mitochondria appears relatively resistant to irreversible impairment following cerebral ischemia.

Bibliography

Ginsberg, M. D., Mela, L., WrobelâKuhl, K., & Reivich, M. (1977). Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil. Annals of Neurology, 1(6), 519â527. Portico.

Authors 4

Myron D. Ginsberg (first)
Leena Mela (additional)
Krystyna Wrobel‐Kuhl (additional)
Martin Reivich (additional)

References 36 Referenced 94

10.1111/j.1471-4159.1975.tb03916.x
10.1016/S0021-9258(18)51740-3
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10.3171/jns.1975.43.3.0323
10.1007/BF00316134
10.1007/978-3-642-65814-3_45
10.1111/j.1748-1716.1970.tb04681.x
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{'key': 'e_1_2_1_18_2', 'first-page': '315', 'article-title': 'Cerebral ischemia in infant and adult gerbils: relation to incomplete circle of Willis', 'volume': '87', 'author': 'Levine S', 'year': '1969', 'journal-title': 'Arch Pathol'} / Arch Pathol / Cerebral ischemia in infant and adult gerbils: relation to incomplete circle of Willis by Levine S (1969)
10.1016/0022-510X(75)90188-4
10.1001/archneur.1975.00490490061005
10.1016/S0021-9258(18)62854-6
10.1021/bi00851a038
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{'key': 'e_1_2_1_25_2', 'first-page': '109', 'volume-title': 'Cellular Biology and Toxicity of Anesthetics', 'author': 'Cohen PJ', 'year': '1972'} / Cellular Biology and Toxicity of Anesthetics by Cohen PJ (1972)
10.1016/0014-5793(74)81057-4
10.1111/j.1399-6576.1975.tb05188.x
10.1111/j.1399-6576.1975.tb05407.x
10.1161/01.STR.5.1.1
10.1161/01.STR.6.4.405
10.1113/jphysiol.1971.sp009336
{'key': 'e_1_2_1_32_2', 'first-page': '59', 'volume-title': 'Cerebral Vascular Diseases', 'author': 'Brierley JB', 'year': '1973'} / Cerebral Vascular Diseases by Brierley JB (1973)
10.1083/jcb.26.3.885
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10.1016/0022-4804(74)90058-4
10.1001/archneur.1963.00460120013001
10.1001/archneur.1973.00490300037004

Dates

Type	When
Created	20 years, 2 months ago (May 27, 2005, 7:07 p.m.)
Deposited	1 year, 9 months ago (Nov. 2, 2023, 7:40 a.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 1:25 a.m.)
Issued	48 years, 2 months ago (June 1, 1977)
Published	48 years, 2 months ago (June 1, 1977)
Published Online	20 years, 10 months ago (Oct. 7, 2004)
Published Print	48 years, 2 months ago (June 1, 1977)

Funders 0

None

BibTeX

@article{Ginsberg_1977, title={Mitochondrial metabolism following bilateral cerebral ischemia in the gerbil}, volume={1}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.410010603}, DOI={10.1002/ana.410010603}, number={6}, journal={Annals of Neurology}, publisher={Wiley}, author={Ginsberg, Myron D. and Mela, Leena and Wrobel‐Kuhl, Krystyna and Reivich, Martin}, year={1977}, month=jun, pages={519–527} }

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