Abstract
AbstractVarious C‐terminally truncated amyloid β peptides (Aβ) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of Aβ38, Aβ40, and Aβ42 were measured by enzyme‐linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF Aβ42 levels was decreased in patients with AD, whereas CSF Aβ38 and Aβ40 levels were similar in patients with AD and control subjects. All three Aβ peptides were interrelated, particularly CSF Aβ38 and Aβ40. Diagnostic accuracy of CSF Aβ42 concentrations was not improved by applying the ratios of CSF Aβ42 to Aβ38 or Aβ40. Ann Neurol 2005;58:139–142
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Dates
Type | When |
---|---|
Created | 20 years, 2 months ago (June 27, 2005, 7:18 p.m.) |
Deposited | 1 year, 10 months ago (Oct. 16, 2023, 3:43 p.m.) |
Indexed | 1 month ago (July 30, 2025, 10:28 a.m.) |
Issued | 20 years, 2 months ago (June 27, 2005) |
Published | 20 years, 2 months ago (June 27, 2005) |
Published Online | 20 years, 2 months ago (June 27, 2005) |
Published Print | 20 years, 2 months ago (July 1, 2005) |
@article{Schoonenboom_2005, title={Amyloid β 38, 40, and 42 species in cerebrospinal fluid: More of the same?}, volume={58}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.20508}, DOI={10.1002/ana.20508}, number={1}, journal={Annals of Neurology}, publisher={Wiley}, author={Schoonenboom, Niki S. and Mulder, Cees and Van Kamp, Gerard J. and Mehta, Sangita P. and Scheltens, Philip and Blankenstein, Marinus A. and Mehta, Pankaj D.}, year={2005}, month=jun, pages={139–142} }