DOI: 10.1002/ana.20032. Localization of white matter volume increase in autism and developmental language disorder

Localization of white matter volume increase in autism and developmental language disorder

10.1002/ana.20032

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractIncreased brain volume in autism appears to be driven mainly by an unexplained white matter enlargement, and we have reported a similar phenomenon in developmental language disorder (DLD). Localization of this enlargement would strongly guide research into its cause, tissue basis, and functional implications. We utilized a white matter parcellation technique that divides cerebral white matter into an outer zone containing the radiate compartment and an inner zone containing sagittal and bridging system compartments. In both high‐functioning autism and DLD, enlargement localized to the radiate white matter (all lobes in autism, all but parietal in DLD), whereas inner zone white matter compartments showed no volume differences from controls. Furthermore, in both autism and DLD, later or longer‐myelinating regions showed greater volume increases over controls. Neither group showed cerebral cortex, corpus callosum, or internal capsule volume differences from control. Radiate white matter myelinates later than deep white matter; this pattern of enlargement thus is consistent with striking postnatal head circumference percentile increases reported in autism. These findings suggest an ongoing postnatal process in both autism and DLD that is probably intrinsic to white matter, that primarily affects intrahemispheric and corticocortical connections, and that places these two disorders on the same spectrum.

Bibliography

Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S. (2004). Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology, 55(4), 530â540. Portico.

Authors 9

Martha R. Herbert (first)
David A. Ziegler (additional)
Nikos Makris (additional)
Pauline A. Filipek (additional)
Thomas L. Kemper (additional)
Joseph J. Normandin (additional)
Heather A. Sanders (additional)
David N. Kennedy (additional)
Verne S. Caviness (additional)

References 48 Referenced 476

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Dates

Type	When
Created	21 years, 5 months ago (March 24, 2004, 3:01 a.m.)
Deposited	1 year, 11 months ago (Sept. 28, 2023, 10:29 a.m.)
Indexed	4 weeks, 2 days ago (July 30, 2025, 10:35 a.m.)
Issued	21 years, 5 months ago (March 22, 2004)
Published	21 years, 5 months ago (March 22, 2004)
Published Online	21 years, 5 months ago (March 22, 2004)
Published Print	21 years, 4 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Herbert_2004, title={Localization of white matter volume increase in autism and developmental language disorder}, volume={55}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.20032}, DOI={10.1002/ana.20032}, number={4}, journal={Annals of Neurology}, publisher={Wiley}, author={Herbert, Martha R. and Ziegler, David A. and Makris, Nikos and Filipek, Pauline A. and Kemper, Thomas L. and Normandin, Joseph J. and Sanders, Heather A. and Kennedy, David N. and Caviness, Verne S.}, year={2004}, month=mar, pages={530–540} }

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