DOI: 10.1002/ana.10669. Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment

Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment

10.1002/ana.10669

Crossref journal-article

Wiley

Annals of Neurology (311)

Abstract

AbstractThe neural basis of the amnesia characterizing early Alzheimer's disease (AD) remains uncertain. Postmortem pathological studies have suggested early involvement of the mesial temporal lobe, whereas in vivo metabolic studies have shown hypometabolism of the posterior cingulate cortex. Using a technique that combined the anatomic precision of magnetic resonance imaging with positron emission tomography, we found severe reductions of metabolism throughout a network of limbic structures (the hippocampal complex, medial thalamus, mamillary bodies, and posterior cingulate) in patients with mild AD. We then studied a cohort with mild cognitive impairment in whom amnesia was the only cognitive abnormality and found comparable hypometabolism through the same network. The AD and mild cognitive impairment groups were differentiated, however, by changes outside this network, the former showing significant hypometabolism in amygdala and temporoparietal and frontal association cortex, whereas the latter did not. The amnesia of very early AD reflects severe but localized limbic dysfunction.

Bibliography

Nestor, P. J., Fryer, T. D., Smielewski, P., & Hodges, J. R. (2003). Limbic hypometabolism in Alzheimerâs disease and mild cognitive impairment. Annals of Neurology, 54(3), 343â351. Portico.

Authors 4

Peter J. Nestor (first)
Tim D. Fryer (additional)
Peter Smielewski (additional)
John R. Hodges (additional)

References 46 Referenced 310

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Dates

Type	When
Created	21 years, 11 months ago (Sept. 2, 2003, 3:35 p.m.)
Deposited	1 year, 10 months ago (Oct. 11, 2023, 2:08 p.m.)
Indexed	1 day, 11 hours ago (Aug. 30, 2025, 1 p.m.)
Issued	22 years ago (Aug. 28, 2003)
Published	22 years ago (Aug. 28, 2003)
Published Online	22 years ago (Aug. 28, 2003)
Published Print	22 years ago (Sept. 1, 2003)

Funders 0

None

BibTeX

@article{Nestor_2003, title={Limbic hypometabolism in Alzheimer’s disease and mild cognitive impairment}, volume={54}, ISSN={1531-8249}, url={http://dx.doi.org/10.1002/ana.10669}, DOI={10.1002/ana.10669}, number={3}, journal={Annals of Neurology}, publisher={Wiley}, author={Nestor, Peter J. and Fryer, Tim D. and Smielewski, Peter and Hodges, John R.}, year={2003}, month=aug, pages={343–351} }

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