DOI: 10.1002/ajpa.1330740104. Hypothesis: A selective advantage for cystic fibrosis heterozygotes

Hypothesis: A selective advantage for cystic fibrosis heterozygotes

10.1002/ajpa.1330740104

Crossref journal-article

Wiley

American Journal of Physical Anthropology (311)

Abstract

AbstractEuropean populations have both a particularly long history of pulmonary tuberculosis and extremely high frequencies of cystic fibrosis (CF). While carriers of the recessive gene are asymptomatic for CF disease, their fibroblasts produce excessive amounts of hyaluronic acid, whose role in successful isolation of virulent pathogens appears to be especially adaptive in host resistance to the human strain of Mycobacterium tuberculosis. CF heterozygosity may have been an adaptation to a disease environment once dominated by this infection.

Bibliography

Meindl, R. S. (1987). Hypothesis: A selective advantage for cystic fibrosis heterozygotes. American Journal of Physical Anthropology, 74(1), 39â45. Portico.

Authors 1

Richard S. Meindl (first)

References 40 Referenced 40

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Dates

Type	When
Created	19 years, 6 months ago (Feb. 3, 2006, 5:49 p.m.)
Deposited	1 year, 10 months ago (Oct. 20, 2023, 8:06 p.m.)
Indexed	4 months, 2 weeks ago (April 8, 2025, 6:05 p.m.)
Issued	37 years, 11 months ago (Sept. 1, 1987)
Published	37 years, 11 months ago (Sept. 1, 1987)
Published Online	20 years, 4 months ago (April 27, 2005)
Published Print	37 years, 11 months ago (Sept. 1, 1987)

Funders 0

None

BibTeX

@article{Meindl_1987, title={Hypothesis: A selective advantage for cystic fibrosis heterozygotes}, volume={74}, ISSN={1096-8644}, url={http://dx.doi.org/10.1002/ajpa.1330740104}, DOI={10.1002/ajpa.1330740104}, number={1}, journal={American Journal of Physical Anthropology}, publisher={Wiley}, author={Meindl, Richard S.}, year={1987}, month=sep, pages={39–45} }

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