DOI: 10.1002/ajmg.b.20125. Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network

Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network

10.1002/ajmg.b.20125

Crossref journal-article

Wiley

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics (311)

Abstract

AbstractA recent study by Persico et al. [2001: Mol Psychiatry 6:150–159] suggests alleles of a CGG polymorphism, just 5′ of the reelin gene (RELN) initiator codon, confer liability for autism, especially alleles bearing 11 or more CGG repeats (long alleles). The association is consistent across both a case‐control and family‐based sample. We attempted to replicate their finding using a larger, independent family‐based sample from the NIH Collaborative Programs of Excellence in Autism (CPEA) Network. In our data, allele transmissions to individuals with autism versus unaffected individuals are unbiased, both when alleles are classified by repeat length and when they are classified into long/short categories. Because of the apparent linkage of autism to chromosome 7q, particularly related to the development of language, we also evaluate the relationship between Reelin alleles and the age at which autism subjects use their first word or first phrase. Neither is significantly associated with Reelin alleles. Our results are not consistent with a major role for Reelin alleles in liability to autism. Published 2004 Wiley‐Liss, Inc.

Bibliography

Devlin, B., Bennett, P., Dawson, G., Figlewicz, D. A., Grigorenko, E. L., McMahon, W., Minshew, N., Pauls, D., Smith, M., Spence, M. A., Rodier, P. M., Stodgell, C., & Schellenberg, G. D. (2004). Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 126B(1), 46â50. Portico.

Authors 13

Bernie Devlin (first)
Pamela Bennett (additional)
Geraldine Dawson (additional)
Denise A. Figlewicz (additional)
Elena L. Grigorenko (additional)
William McMahon (additional)
Nancy Minshew (additional)
David Pauls (additional)
Moyra Smith (additional)
M. Anne Spence (additional)
Patricia M. Rodier (additional)
Chris Stodgell (additional)
Gerard D. Schellenberg (additional)

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Dates

Type	When
Created	21 years, 5 months ago (March 23, 2004, 8:33 a.m.)
Deposited	1 year, 10 months ago (Oct. 18, 2023, 10:18 a.m.)
Indexed	1 year, 1 month ago (July 4, 2024, 6:35 p.m.)
Issued	21 years, 6 months ago (Feb. 5, 2004)
Published	21 years, 6 months ago (Feb. 5, 2004)
Published Online	21 years, 6 months ago (Feb. 5, 2004)
Published Print	21 years, 4 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Devlin_2004, title={Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network}, volume={126B}, ISSN={1552-485X}, url={http://dx.doi.org/10.1002/ajmg.b.20125}, DOI={10.1002/ajmg.b.20125}, number={1}, journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics}, publisher={Wiley}, author={Devlin, Bernie and Bennett, Pamela and Dawson, Geraldine and Figlewicz, Denise A. and Grigorenko, Elena L. and McMahon, William and Minshew, Nancy and Pauls, David and Smith, Moyra and Spence, M. Anne and Rodier, Patricia M. and Stodgell, Chris and Schellenberg, Gerard D.}, year={2004}, month=feb, pages={46–50} }

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