DOI: 10.1002/aja.1002040410. Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning

Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning

10.1002/aja.1002040410

Crossref journal-article

Wiley

Developmental Dynamics (311)

Abstract

AbstractMembers of the fibroblast growth factor (FGF) family of growth factors are key regulators of limb skeletal patterning and growth. Abnormal expression of FGFs or mutations in their receptors (fgfrs) result in skeletal disorders. Here we show that changes in the expression of fgfrs are intrinsic properties of differentiating cartilage. In mesenchymal micromass cultures differentiating into cartilage, as in ovo, fgfr 1 mRNA was found predominantly in undifferentiated, proliferating mesenchyme, fgfr 2 in precartilage cell aggregates, and fgfr 3 in differentiating cartilage nodules. Thus, our data suggest that switches in the expression of fgfr 1, 2, and 3 mRNAs are associated with phases of cartilage patterning both in vitro and in ovo, and mark distinct stages in the development of the limb skeleton. © 1995 wiley‐Liss, Inc.

Bibliography

Szebenyi, G., Savage, M. P., Olwin, B. B., & Fallon, J. F. (1995). Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning. Developmental Dynamics, 204(4), 446â456. Portico.

Authors 4

Györgyi Szebenyi (first)
Mary Pfann Savage (additional)
Bradley B. Olwin (additional)
John F. Fallon (additional)

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 9:02 p.m.)
Deposited	1 year, 10 months ago (Oct. 26, 2023, 10:57 p.m.)
Indexed	3 months, 3 weeks ago (May 5, 2025, 7:44 a.m.)
Issued	29 years, 8 months ago (Dec. 1, 1995)
Published	29 years, 8 months ago (Dec. 1, 1995)
Published Online	20 years, 6 months ago (Feb. 3, 2005)
Published Print	29 years, 8 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Szebenyi_1995, title={Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning}, volume={204}, ISSN={1097-0177}, url={http://dx.doi.org/10.1002/aja.1002040410}, DOI={10.1002/aja.1002040410}, number={4}, journal={Developmental Dynamics}, publisher={Wiley}, author={Szebenyi, Györgyi and Savage, Mary Pfann and Olwin, Bradley B. and Fallon, John F.}, year={1995}, month=dec, pages={446–456} }

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