DOI: 10.1002/aja.1002040305. Relationship between fibronectin expression during gastrulation and heart formation in the rat embryo

Relationship between fibronectin expression during gastrulation and heart formation in the rat embryo

10.1002/aja.1002040305

Crossref journal-article

Wiley

Developmental Dynamics (311)

Abstract

AbstractBy utilizing myosin immunostaining, we were able to identify early rat myocardium as a thin epithelial sheet and realized that its cohesive movement toward the midline leads to the straight heart tube formation. Localization study of fibronectin mRNA and protein was, therefore, carried out to investigate its tissue origin and possible roles in facilitating mesoderm migration and heart formation. Fibronectin mRNAs were first detected throughout the mesoderm during the early primitive streak stage, suggesting that the mesoderm is the source of fibronectin. By pre‐head fold (pre‐somite) and head fold (early somite) stages, the mesoderm became largely down‐regulated for fibronectin mRNAs, while it was also at these stages when myosin‐positive myocardium formed itself into the epithelium and was subsequently folding toward the midline. Thus, there appears to be little fibronectin synthesis during and directly relevant to early heart tube formation. Later, during the early straight heart tube stage (5 somite and older), endocardium became highly positive for fibronectin mRNAs, suggesting that the endocardium is the major source of fibronectin for the cardiac jelly. Based on the results, we present a map for the early mammalian heart in which the heart is a single crescentic band lying in front of the prechordal plate. We also suggest a process for heart tube formation based on the cohesive movement of the myocardial epithelium. During heart tube formation, fibronectin protein had been deposited previously by the mesoderm and was found uniformly in the ECM and not newly produced by any adjacent tissue. The data contradict the endodermal guidance of heart migration by fibronectin gradient and suggest, instead, a permissive role for the fibronectin substrate. © 1995 wiley‐Liss, Inc.

Bibliography

Suzuki, H. R., Solursh, M., & Baldwin, H. S. (1995). Relationship between fibronectin expression during gastrulation and heart formation in the rat embryo. Developmental Dynamics, 204(3), 259â277. Portico.

Authors 3

Hiroaki R. Suzuki (first)
Michael Solursh (additional)
H. Scott Baldwin (additional)

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 9:02 p.m.)
Deposited	8 months, 1 week ago (Dec. 24, 2024, 5:54 p.m.)
Indexed	2 months ago (July 1, 2025, 3:16 p.m.)
Issued	29 years, 10 months ago (Nov. 1, 1995)
Published	29 years, 10 months ago (Nov. 1, 1995)
Published Online	20 years, 7 months ago (Feb. 3, 2005)
Published Print	29 years, 10 months ago (Nov. 1, 1995)

Funders 0

None

BibTeX

@article{Suzuki_1995, title={Relationship between fibronectin expression during gastrulation and heart formation in the rat embryo}, volume={204}, ISSN={1097-0177}, url={http://dx.doi.org/10.1002/aja.1002040305}, DOI={10.1002/aja.1002040305}, number={3}, journal={Developmental Dynamics}, publisher={Wiley}, author={Suzuki, Hiroaki R. and Solursh, Michael and Baldwin, H. Scott}, year={1995}, month=nov, pages={259–277} }

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