DOI: 10.1002/aja.1001420106. Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO<sub>4</sub> and its subsequent regeneration

Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration

10.1002/aja.1001420106

Crossref journal-article

Wiley

American Journal of Anatomy (311)

Abstract

AbstractRegeneration of olfactory epithelium was studied at the ultrastructural level in two different strains of mice (C57B1/6J and SWR/J) following destructive changes induced by nasal irrigation with a 1% aqueous solution of zinc sulfate (ZnSO4).Three epithelial conditions were seen during the first four to 14 days following treatment: a “surface alteration” state characterized by changes at the apical ends of olfactory and columnar supporting cells, a “squamous‐metaplastic” state, and a “simple‐squamous” state. In the latter two conditions, thought to represent regenerative states, cells contained inclusions similar to secretion granules in Bowman's glands. This observation supports earlier suggestions that new epithelial cells originate from these glands. Later regenerative changes consist of differentiation of new sensory cells and columnar supporting cells in an initially disorganized epithelium. This epithelium then changes to a normal, pseudostratified organization.Regeneration of the epithelium begins earlier and proceeds more rapidly in the SWR/J strain than in C57B1/6J mice. Possibly, a genetle difference exists between strains. After 72 days the epithelium in both strains had regenerated.

Bibliography

Matulionis, D. H. (1975). Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration. American Journal of Anatomy, 142(1), 67â89. Portico.

Authors 1

Daniel H. Matulionis (first)

References 21 Referenced 98

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{'key': 'e_1_2_1_6_1', 'first-page': '72', 'article-title': 'The effect of zinc sulfate on the olfactory mucus membrane in dogs and monkeys', 'volume': '24', 'author': 'Hunnicutt L. G.', 'year': '1939', 'journal-title': 'Tr. Pacific Coast Oto‐Ophth. Soc.'} / Tr. Pacific Coast Oto‐Ophth. Soc. / The effect of zinc sulfate on the olfactory mucus membrane in dogs and monkeys by Hunnicutt L. G. (1939)
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{'key': 'e_1_2_1_16_1', 'first-page': '1', 'article-title': 'Repair of the olfactory mucosa', 'volume': '37', 'author': 'Schultz E. W.', 'year': '1960', 'journal-title': 'Am. J. Path.'} / Am. J. Path. / Repair of the olfactory mucosa by Schultz E. W. (1960)
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{'key': 'e_1_2_1_18_1', 'first-page': '138', 'article-title': 'Changes in the olfactory mucosa and the olfactory nerves following intranasal treatment with one per cent zinc sulfate', 'volume': '39', 'author': 'Smith C. G.', 'year': '1938', 'journal-title': 'Canad. Med. Assoc. J.'} / Canad. Med. Assoc. J. / Changes in the olfactory mucosa and the olfactory nerves following intranasal treatment with one per cent zinc sulfate by Smith C. G. (1938)
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Dates

Type	When
Created	20 years, 6 months ago (Feb. 26, 2005, 9:06 a.m.)
Deposited	1 year, 10 months ago (Nov. 1, 2023, 3:56 p.m.)
Indexed	2 months ago (July 7, 2025, 1:45 a.m.)
Issued	50 years, 8 months ago (Jan. 1, 1975)
Published	50 years, 8 months ago (Jan. 1, 1975)
Published Online	20 years, 7 months ago (Feb. 3, 2005)
Published Print	50 years, 8 months ago (Jan. 1, 1975)

Funders 0

None

BibTeX

@article{Matulionis_1975, title={Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration}, volume={142}, ISSN={1553-0795}, url={http://dx.doi.org/10.1002/aja.1001420106}, DOI={10.1002/aja.1001420106}, number={1}, journal={American Journal of Anatomy}, publisher={Wiley}, author={Matulionis, Daniel H.}, year={1975}, month=jan, pages={67–89} }

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