DOI: 10.1002/aja.1001350308. Ultrastructure of the human submaxillary gland IV. Serous granules

Ultrastructure of the human submaxillary gland IV. Serous granules

10.1002/aja.1001350308

Crossref journal-article

Wiley

American Journal of Anatomy (311)

Abstract

AbstractAcinar serous granules in specimens of human submaxillary gland fixed with aldehydes followed by osmium were examined in the electron microscope. Typical mature granules had a tripartite substructure: (1) an eccentrically placed dense spherule; (2) material of intermediate density adherent to the inner aspect of the granule membrane in the form of a crescent; and (3) a less dense, homogeneously fibrillo‐granular matrix. The dense spherules appeared within expanded Golgi saccules; other granule constituents apparently were of secondary acquisition. A few cells contained atypical serous granules in which material of intermediate density was disposed in random loops, whorls, and striae. Such granules usually lacked dense spherules. It is postulated that the two morphologically distinct types of granules represent separate classes of serous secretory products.

Bibliography

Tandler, B., & Erlandson, R. A. (1972). Ultrastructure of the human submaxillary gland IV. Serous granules. American Journal of Anatomy, 135(3), 419â433. Portico.

Authors 2

Bernard Tandler (first)
Robert A. Erlandson (additional)

References 35 Referenced 46

10.1083/jcb.41.3.753
10.1083/jcb.29.2.199
{'key': 'e_1_2_1_4_1', 'volume-title': 'Secretory Mechanism of the Digestive Glands', 'author': 'Babkin B. P.', 'year': '1950'} / Secretory Mechanism of the Digestive Glands by Babkin B. P. (1950)
10.1086/394335
10.1016/0003-9969(67)90216-6
10.1083/jcb.53.2.290
10.1002/jmor.1051320202
{'key': 'e_1_2_1_9_1', 'first-page': '273', 'article-title': 'Electron microscopy of squirrel monkey parotid glands', 'volume': '7', 'author': 'Cowley L. H.', 'year': '1970', 'journal-title': 'Ala. J. Med. Sci.'} / Ala. J. Med. Sci. / Electron microscopy of squirrel monkey parotid glands by Cowley L. H. (1970)
{'key': 'e_1_2_1_10_1', 'first-page': '531', 'volume-title': 'Handbook of Physiology. Sec. 6', 'author': 'Ellison S. A.', 'year': '1967'} / Handbook of Physiology. Sec. 6 by Ellison S. A. (1967)
10.1083/jcb.22.3.704
{'key': 'e_1_2_1_12_1', 'first-page': '223', 'article-title': 'Über die Ultrastruktur de Azinarzellen menschlicher Speicheldrüsen und deren Veränderung unter Zitronenreiz', 'volume': '117', 'author': 'Eschler J.', 'year': '1965', 'journal-title': 'Anat. Anz.'} / Anat. Anz. / Über die Ultrastruktur de Azinarzellen menschlicher Speicheldrüsen und deren Veränderung unter Zitronenreiz by Eschler J. (1965)
{'key': 'e_1_2_1_13_1', 'first-page': '128', 'article-title': 'Bau und Struktur der Speichldrüsen unter Berücksichtigung eigener elektronenmikroskopischer Beobachtungen am Menschen', 'volume': '16', 'author': 'Ferner H.', 'year': '1961', 'journal-title': 'Deut. Zahnärzt. Z.'} / Deut. Zahnärzt. Z. / Bau und Struktur der Speichldrüsen unter Berücksichtigung eigener elektronenmikroskopischer Beobachtungen am Menschen by Ferner H. (1961)
10.1007/BF00340928
10.1083/jcb.44.2.340
10.1152/ajplegacy.1960.198.1.108 / Am. J. Physiol. / Effects of atropine on synthesis and secretion of pepsinogen in the rat by Hirschowitz B. I. (1960)
10.1083/jcb.50.1.135
10.1111/j.1476-5381.1958.tb00193.x
10.1002/aja.1001310204
{'key': 'e_1_2_1_20_1', 'first-page': '137A', 'article-title': 'A formaldehyde‐glutaraldehyde fixative of high osmolality for use in electron microscopy', 'volume': '27', 'author': 'Karnovsky M. J.', 'year': '1965', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. / A formaldehyde‐glutaraldehyde fixative of high osmolality for use in electron microscopy by Karnovsky M. J. (1965)
10.1083/jcb.33.3.720
10.1159/000143243
{'key': 'e_1_2_1_23_1', 'first-page': '192', 'article-title': 'The effect of pharmacological agents on salivary secretion and composition in man. I. Pilocarpine, atropine and anticholinesterases', 'volume': '4', 'author': 'Mandel I. D.', 'year': '1967', 'journal-title': 'J. Oral Therapeut. Pharmacol.'} / J. Oral Therapeut. Pharmacol. / The effect of pharmacological agents on salivary secretion and composition in man. I. Pilocarpine, atropine and anticholinesterases by Mandel I. D. (1967)
10.1083/jcb.11.3.736
10.1002/aja.1001150303
10.1083/jcb.14.2.221
{'key': 'e_1_2_1_27_1', 'first-page': '64', 'volume-title': 'Subcellular Particles', 'author': 'Palade G. E.', 'year': '1959'} / Subcellular Particles by Palade G. E. (1959)
10.1083/jcb.17.1.208
10.1083/jcb.17.1.19
{'key': 'e_1_2_1_30_1', 'first-page': '1', 'article-title': 'On the secretory granules of the serous cell in the human submandibular gland', 'volume': '15', 'author': 'Sato M.', 'year': '1966', 'journal-title': 'J. Elect. Micr.'} / J. Elect. Micr. / On the secretory granules of the serous cell in the human submandibular gland by Sato M. (1966)
10.1016/B978-1-4832-2871-6.50009-6
10.1002/aja.1001110104
{'key': 'e_1_2_1_33_1', 'first-page': '180', 'article-title': 'Structural and histochemical diversity in mammalian salivary glands', 'volume': '5', 'author': 'Shackleford J. M.', 'year': '1968', 'journal-title': 'Ala. J. Med. Sci.'} / Ala. J. Med. Sci. / Structural and histochemical diversity in mammalian salivary glands by Shackleford J. M. (1968)
10.1083/jcb.22.3.697
10.1002/aja.1001110304
10.1016/S0022-5320(72)80017-0

Dates

Type	When
Created	20 years, 5 months ago (Feb. 26, 2005, 9:26 a.m.)
Deposited	1 year, 9 months ago (Nov. 1, 2023, 1:30 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 7, 2024, 7:53 p.m.)
Issued	52 years, 9 months ago (Nov. 1, 1972)
Published	52 years, 9 months ago (Nov. 1, 1972)
Published Online	20 years, 6 months ago (Feb. 3, 2005)
Published Print	52 years, 9 months ago (Nov. 1, 1972)

Funders 0

None

BibTeX

@article{Tandler_1972, title={Ultrastructure of the human submaxillary gland IV. Serous granules}, volume={135}, ISSN={1553-0795}, url={http://dx.doi.org/10.1002/aja.1001350308}, DOI={10.1002/aja.1001350308}, number={3}, journal={American Journal of Anatomy}, publisher={Wiley}, author={Tandler, Bernard and Erlandson, Robert A.}, year={1972}, month=nov, pages={419–433} }

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