Abstract
AbstractAsymmetric catalysis, in its infancy in the 1960s, has dramatically changed the procedures of chemical synthesis, and resulted in an impressive progression to a level that technically approximates or sometimes even exceeds that of natural biological processes. The recent exceptional advances in this area attest to a range of conceptual breakthroughs in chemical sciences in general, and to the practical benefits of organic synthesis, not only in laboratories but also in industry. The growth of this core technology has given rise to enormous economic potential in the manufacture of pharmaceuticals, animal health products, agrochemicals, fungicides, pheromones, flavors, and fragrances. Practical asymmetric catalysis is of growing importance to a sustainable modern society, in which environmental protection is of increasing concern. This subject is an essential component of molecular science and technology in the 21st century. Most importantly, recent progress has spurred various interdisciplinary research efforts directed toward the creation of molecularly engineered novel functions. The origin and progress of my research in this field are discussed.
References
191
Referenced
338
- For example
{'key': 'e_1_2_1_2_2', 'volume-title': 'The New Ambidextrous Universe, 3rd ed.', 'author': 'Gardner M.', 'year': '1990'}
/ The New Ambidextrous Universe, 3rd ed. by Gardner M. (1990){'key': 'e_1_2_1_3_2', 'volume-title': 'Reflections on Symmetry', 'author': 'Heilbronner E.', 'year': '1993'}
/ Reflections on Symmetry by Heilbronner E. (1993){'key': 'e_1_2_1_4_2', 'volume-title': 'The Same and Not the Same', 'author': 'Hoffmann R.', 'year': '1995'}
/ The Same and Not the Same by Hoffmann R. (1995){'key': 'e_1_2_1_5_2', 'volume-title': 'Rechts oder links in der Natur und anderswo', 'author': 'Brunner. H.', 'year': '1999'}
/ Rechts oder links in der Natur und anderswo by Brunner. H. (1999){'key': 'e_1_2_1_6_2', 'first-page': '1640', 'volume': '29', 'author': 'Blaschke G.', 'year': '1979', 'journal-title': 'Arzneim.‐Forsch.'}
/ Arzneim.‐Forsch. by Blaschke G. (1979)- This interpretation must be considered carefully because theR enantiomer racemizesin vivo.
10.1145/127248.127249
10.1021/cen-v068n028.p009
10.1021/cen-v070n039.p046
10.1021/cen-v079n020.p045
{'key': 'e_1_2_1_12_2', 'volume-title': 'Asymmetric Catalysis in Organic Synthesis', 'author': 'Noyori R.', 'year': '1994'}
/ Asymmetric Catalysis in Organic Synthesis by Noyori R. (1994)10.1016/S0040-4039(01)89263-7
10.1016/S0040-4020(01)91998-2
10.1351/pac198557121839
10.1007/978-3-642-58571-5_22
10.1039/tf9383401181
10.1021/ja01877a072
10.1021/ja01464a055
{'key': 'e_1_2_1_20_2', 'first-page': '131', 'author': 'Young J. F.', 'year': '1965', 'journal-title': 'Chem. Commun.'}
/ Chem. Commun. by Young J. F. (1965)10.1038/178323b0
{'key': 'e_1_2_1_22_2', 'first-page': '1445', 'author': 'Knowles W. S.', 'year': '1968', 'journal-title': 'Chem. Commun.'}
/ Chem. Commun. by Knowles W. S. (1968)10.1002/1521-3757(20020617)114:12<2096::AID-ANGE2096>3.0.CO;2-Z
10.1002/1521-3773(20020617)41:12<1998::AID-ANIE1998>3.0.CO;2-8
10.1002/ange.19680802413
10.1002/anie.196809422
- These achievements were based on the classic work of Mislow and Horner on resolution of chiral tertiary phosphanes:
10.1021/ja01020a017
10.1351/pac196409020225
10.1039/c29710000481
10.1039/c39720000010
10.1021/ja00460a018
10.1021/ar00087a006
{'key': 'e_1_2_1_32_2', 'volume-title': 'Chirality in Industry: The Commercial Manufacture and Applications of Optically Active Compounds', 'author': 'Crosby J.', 'year': '1992'}
/ Chirality in Industry: The Commercial Manufacture and Applications of Optically Active Compounds by Crosby J. (1992)10.1021/ja00711a083
10.1002/ange.19730852303
10.1002/anie.197309541
{'key': 'e_1_2_1_35_2', 'first-page': '83', 'volume': '25', 'author': 'Noyori R.', 'year': '1985', 'journal-title': 'Chem. Scr.'}
/ Chem. Scr. by Noyori R. (1985)10.1021/ja00547a020
10.1016/S0040-4020(01)82411-X
10.1021/ja00329a014
10.1021/jo00355a012
{'key': 'e_1_2_1_40_2', 'first-page': '6', 'volume': '76', 'author': 'Cai D.', 'year': '1998', 'journal-title': 'Org. Synth.'}
/ Org. Synth. by Cai D. (1998)10.1107/S0567740882004129
10.1039/c39820000600
10.1021/ja00330a029
{'key': 'e_1_2_1_44_2', 'first-page': '75', 'volume-title': 'Organic Synthesis in Japan: Past, Present, and Future', 'author': 'Akutagawa S.', 'year': '1992'}
/ Organic Synthesis in Japan: Past, Present, and Future by Akutagawa S. (1992){'key': 'e_1_2_1_45_2', 'volume-title': 'Chirality in Industry: The Commercial Manufacture and Applications of Optically Active Compounds', 'author': 'Akutagawa S.', 'year': '1992'}
/ Chirality in Industry: The Commercial Manufacture and Applications of Optically Active Compounds by Akutagawa S. (1992){'key': 'e_1_2_1_46_2', 'volume-title': 'Asymmetric Synthesis Vol.\u20055', 'author': 'Otsuka S.', 'year': '1985'}
/ Asymmetric Synthesis Vol. 5 by Otsuka S. (1985)10.1055/s-1991-26541
10.3891/acta.chem.scand.50-0353
10.15227/orgsyn.067.0048
10.1021/om00046a005
10.1039/cs9891800187
10.1126/science.248.4960.1194
10.1021/ar00178a005
{'key': 'e_1_2_1_54_2', 'first-page': '360', 'volume': '22', 'author': 'Noyori R.', 'year': '1992', 'journal-title': 'CHEMTECH'}
/ CHEMTECH by Noyori R. (1992)10.1016/S0040-4020(01)89365-0
{'key': 'e_1_2_1_56_2', 'first-page': '1', 'volume-title': '(IUPAC) Stereocontrolled Organic Synthesis', 'author': 'Noyori R.', 'year': '1994'}
/ (IUPAC) Stereocontrolled Organic Synthesis by Noyori R. (1994)10.3891/acta.chem.scand.50-0380
10.1039/j19680003143
10.1039/c39750000574
10.1021/ja00240a025
10.1021/ja00529a029
10.1021/ja000813n
10.1021/ja00282a054
10.1021/ic00276a025
10.1021/jo00040a068
{'key': 'e_1_2_1_66_2', 'first-page': '74', 'volume': '72', 'author': 'Takaya H.', 'year': '1993', 'journal-title': 'Org. Synth.'}
/ Org. Synth. by Takaya H. (1993)10.1016/S0040-4039(00)97276-9
10.1021/ja00002a029
10.1021/jo00390a043
10.1021/ja00239a065
10.1021/ja00239a065
10.1021/jo00238a048
10.1016/S0040-4039(00)96636-X
10.1021/jo00081a007
10.1016/S0957-4166(00)86107-8
{'key': 'e_1_2_1_75_2', 'first-page': '281', 'volume': '1', 'author': 'Kitamura M.', 'year': '1996', 'journal-title': 'Enantiomer'}
/ Enantiomer by Kitamura M. (1996)10.1039/C39850000922
10.1016/0040-4039(90)87031-T
- For other synthetic applications see reviews:
10.1002/ange.19911031004
10.1002/anie.199111933
{'key': 'e_1_2_1_80_2', 'first-page': '3', 'volume-title': 'Transition Metals for Organic Synthesis, Vol.\u20052', 'author': 'Börner A.', 'year': '1998'}
/ Transition Metals for Organic Synthesis, Vol. 2 by Börner A. (1998){'key': 'e_1_2_1_81_2', 'first-page': '121', 'volume-title': 'Comprehensive Asymmetric Catalysis, Vol.\u20051', 'author': 'Brown J. M.', 'year': '1999'}
/ Comprehensive Asymmetric Catalysis, Vol. 1 by Brown J. M. (1999)10.1002/0471721506.ch1
10.1016/S0040-4039(00)79892-3
10.15227/orgsyn.071.0001
10.1021/jo00090a026
10.1021/ja00210a070
10.1039/C39890001208
10.1016/S0040-4039(00)97885-7
10.1016/S0040-4039(00)80350-0
10.1016/S0040-4039(00)82338-2
10.1021/ja00207a038
10.1016/S0957-4166(00)82262-4
10.1021/ja00054a020
10.1016/S0040-4020(01)80541-X
10.1246/bcsj.68.36
10.1016/00404-0399(50)11355-
10.1021/ja00115a030
10.1021/ja00398a047
10.1021/ja00253a051
10.1021/ja01097a051
10.1021/ja01097a054
10.1016/0040-4020(79)87003-9
10.1021/ja00775a053
10.1021/ja00427a061
10.1021/ja00334a041
10.1021/ja00334a042
10.1021/bk-1996-0641.ch001
10.1021/cr00097a010
10.1002/(SICI)1521-3757(19980803)110:15<2092::AID-ANGE2092>3.0.CO;2-M
10.1002/(SICI)1521-3773(19980817)37:15<1986::AID-ANIE1986>3.0.CO;2-Z
- For early efforts see:
{'key': 'e_1_2_1_111_2', 'first-page': '421', 'volume': '5', 'author': 'Solodar J.', 'year': '1975', 'journal-title': 'CHEMTECH'}
/ CHEMTECH by Solodar J. (1975)10.1016/0040-4039(76)80113-X
10.1016/S0022-328X(00)84458-7
10.1016/0022-328X(85)87004-2
10.1021/ja00061a036
10.1002/chem.19970030824
10.1515/znb-1998-0301
10.1002/(SICI)1521-3757(19980420)110:8<1203::AID-ANGE1203>3.0.CO;2-M
10.1002/(SICI)1521-3773(19980504)37:8<1100::AID-ANIE1100>3.0.CO;2-3
10.1021/jo981859q
10.1007/978-1-4615-1909-6_7
10.1007/978-1-4615-1909-6_8
10.1021/ja00114a043
10.1002/1521-3757(20010105)113:1<40::AID-ANGE40>3.0.CO;2-K
10.1002/1521-3773(20010105)40:1<40::AID-ANIE40>3.0.CO;2-5
10.1351/pac199971081493
10.1351/pac200173020227
- Abbreviations: TolBINAP=2 2′‐Bis(di‐4‐tolylphosphano)‐1 1′‐binaphthyl. XylBINAP=2 2′‐Bis(di‐3 5‐xylylphosphano)‐1 1′‐binaphthyl. DPEN=1 2‐Diphenylethylenediamine. DAIPEN=1 1‐Di‐4‐anisyl‐2‐isopropyl‐1 2‐ethylenediamine.
10.1021/ja983257u
10.1021/ja00146a041
10.1055/s-1997-6141
10.1021/ol0000814
10.1021/jo960997h
10.1016/S0040-4039(99)00929-6
10.1021/ja001098k
10.1021/ol9904139
10.1021/ja972897e
10.1002/1615-4169(20010430)343:4<369::AID-ADSC369>3.0.CO;2-3
10.1002/1521-3757(20001016)112:20<3676::AID-ANGE3676>3.0.CO;2-W
10.1002/1521-3773(20001016)39:20<3532::AID-ANIE3532>3.0.CO;2-L
10.1002/(SICI)1521-3757(19990215)111:4<517::AID-ANGE517>3.0.CO;2-E
10.1002/(SICI)1521-3773(19990215)38:4<495::AID-ANIE495>3.0.CO;2-O
10.1002/1521-3757(20001016)112:20<3854::AID-ANGE3854>3.0.CO;2-#
10.1002/1521-3773(20001016)39:20<3707::AID-ANIE3707>3.0.CO;2-M
- Nonlinear effects in catalysis should be investigated carefully because of the homochiral and heterochiral interaction of the chiral species present in the catalytic system. For reviews see:
10.1002/tcr.1
10.1002/(SICI)1521-3757(19981102)110:21<3088::AID-ANGE3088>3.0.CO;2-A
10.1002/(SICI)1521-3773(19981116)37:21<2922::AID-ANIE2922>3.0.CO;2-1
10.1002/9780470147313.ch5
10.1002/(SICI)1521-3757(19980619)110:12<1792::AID-ANGE1792>3.0.CO;2-9
10.1002/(SICI)1521-3773(19980703)37:12<1703::AID-ANIE1703>3.0.CO;2-I
- The ketone substrate reacts in an outer sphere of the coordinatively saturated 18‐electron complex without interaction with the metallic center. Thus the general scheme given in Figure 1 is to be modified to some extent. For other mechanistic investigations see:
10.1021/ja015902u
10.1002/1521-3757(20011001)113:19<3693::AID-ANGE3693>3.0.CO;2-D
10.1002/1521-3773(20011001)40:19<3581::AID-ANIE3581>3.0.CO;2-7
10.1021/jo010721w
10.1021/ar9502341
10.1021/ja971570a
10.1021/ol0002119
10.1002/ange.19971090333
10.1002/anie.199702851
10.1021/ja991638h
10.1021/ja9906610
10.1002/1521-3757(20010803)113:15<2900::AID-ANGE2900>3.0.CO;2-8
10.1002/1521-3773(20010803)40:15<2818::AID-ANIE2818>3.0.CO;2-Y
10.1021/ja00297a051
10.1021/ja00222a033
10.1016/S0040-4020(01)85596-4
{'key': 'e_1_2_1_157_2', 'first-page': '22', 'author': 'Suzuki M.', 'year': '1989', 'journal-title': 'Synlett'}
/ Synlett by Suzuki M. (1989)- This process has been used at Ono Pharmaceutical Co. for the industrial synthesis of PGs using the Corey method.
10.1002/ange.19840961106
10.1002/anie.198408471
{'key': 'e_1_2_1_160_2', 'first-page': '173', 'volume': '3', 'author': 'Noyori R.', 'year': '1990', 'journal-title': 'Chemtracts: Org. Chem.'}
/ Chemtracts: Org. Chem. by Noyori R. (1990)10.1126/science.8418493
10.1002/ange.19961080326
10.1002/anie.199603341
10.1074/jbc.271.10.5901
10.1246/bcsj.73.1053
10.1046/j.1471-4159.1999.0722583.x
10.1002/chem.19970031219
10.1016/S0040-4020(00)00734-1
10.1046/j.1460-9568.1999.00791.x
{'key': 'e_1_2_1_169_2', 'volume-title': 'Applied Homogeneous Catalysis by Organometallic Complexes, 2nd ed.', 'author': 'Noyori R.'}
/ Applied Homogeneous Catalysis by Organometallic Complexes, 2nd ed. by Noyori R.10.1002/1521-3757(20020617)114:12<2126::AID-ANGE2126>3.0.CO;2-6
10.1002/1521-3773(20020617)41:12<2024::AID-ANIE2024>3.0.CO;2-O
Dates
Type | When |
---|---|
Created | 22 years, 7 months ago (Jan. 24, 2003, 11:09 a.m.) |
Deposited | 1 year, 11 months ago (Aug. 31, 2023, 9:51 a.m.) |
Indexed | 4 minutes ago (Aug. 28, 2025, 8:50 a.m.) |
Issued | 22 years, 7 months ago (Jan. 1, 2003) |
Published | 22 years, 7 months ago (Jan. 1, 2003) |
Published Online | 22 years, 7 months ago (Jan. 21, 2003) |
Published Print | 22 years, 7 months ago (Jan. 1, 2003) |
@article{Noyori_2003, title={Asymmetric Catalysis: Science and Opportunities (Nobel Lecture 2001)}, volume={345}, ISSN={1615-4169}, url={http://dx.doi.org/10.1002/adsc.200390002}, DOI={10.1002/adsc.200390002}, number={1–2}, journal={Advanced Synthesis & Catalysis}, publisher={Wiley}, author={Noyori, Ryoji}, year={2003}, month=jan, pages={15–32} }