DOI: 10.1002/adma.19940060703. Starburst/Cascade Dendrimers: Fundamental building blocks for a new nanoscopic chemistry set

Starburst/Cascade Dendrimers: Fundamental building blocks for a new nanoscopic chemistry set

10.1002/adma.19940060703

Crossref journal-article

Wiley

Advanced Materials (311)

Abstract

That dendrimer structures act as fundamental chemical building blocks (see Figure), forming a “nanoscopic chemistry set” analogous to the “picoscopic chemistry set” formed by atoms, is discussed in this review. Following the logic used by 19th century chemists while defining the atomic “chemistry set”, it is shown that the ability to preface directionality in dendrimer systems validates this approach. magnified image

Bibliography

Tomalia, D. A. (1994). Starburst/Cascade Dendrimers: Fundamental building blocks for a new nanoscopic chemistry set. Advanced Materials, 6(7â8), 529â539. Portico.

Authors 1

Donald A. Tomalia (first)

References 66 Referenced 278

Based on an invited lecture presented at the 33rd National Organic Chemistry Symposium (Bozeman MT; June 13–17 1993).
10.1051/jphyslet:01983004409035100
E.Buhleier W.Wehner F.Vögtie Synthesis1978 155. (10.1055/s-1978-24702)
R. G.Denkewalter J. F.Kolc W. J.Lukasavage US Patent 4410688 1983;
{'key': 'e_1_2_1_4_3', 'first-page': '103907', 'volume': '100', 'year': '1984', 'journal-title': 'Chem. Abstr.'} / Chem. Abstr. (1984)
10.1021/jo00211a052
10.1021/ja00264a054
5cG. R.Newkome G. R.Baker M. J.Saunders P. S.Russo V. K.Gupta Z.‐Q.Yao J. E.Miller K.Bouillion J. Chem. Soc. Chem. Commun.1986 752. (10.1039/c39860000752)
10.1021/jo00056a023
(a)D. A.Tomalia (August 1984) 1st Society Polymer Science Japan International Polym. Conf. Kyoto Japan; (See also reference [1]).
(b)D. A.Tomalia (19 March 1985) 6th Biennial CarlS.MarvelSymp. Tucson AZ USA.
10.1295/polymj.17.117
10.1021/ma00163a029
10.1021/ma00171a051
10.1021/jo00234a006
(g)D. A.Tomalia J. R.Dewald US Patent 4 507 466 1985;
US Patent 4 558 120 1985;
US Patent 4 568 737 1986;
US Patent 4 587 329 1986;
US Patent 4 631 337 1986;
US Patent 4 694 064 1987;
US Patent 4 713 975 1987;
US Patent 4 737 550 1988;
US Patent 4 8711 779 1989;
US Patent 4 857 599 1989.
10.1021/ja00239a068
(i)D. A.Tomalia Bürgenstock Conf. May 3 1987 Bürgenstock Switzerland.
10.1002/nadc.19870350704
10.1002/anie.199001381
10.1002/anie.199313061
10.1002/anie.199313081
10.1002/cber.19931260925
{'key': 'e_1_2_1_8_2', 'first-page': '115', 'volume': '30', 'author': 'Wilson L. R.', 'year': '1989', 'journal-title': 'Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)'} / Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) by Wilson L. R. (1989)
10.1021/ja00175a062
{'key': 'e_1_2_1_9_3', 'first-page': '182', 'volume': '33', 'author': 'Roovers J.', 'year': '1992', 'journal-title': 'Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)'} / Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) by Roovers J. (1992)
(c)A. W.van der Made P. W. N. M.van Leeuwen J. Chem. Soc. Chem. Commun.1992 1400. (10.1039/c39920001400)
10.1002/adma.19930050613
10.1021/ma00057a013
{'key': 'e_1_2_1_10_2', 'first-page': '119', 'volume': '30', 'author': 'Tomalia D. A.', 'year': '1989', 'journal-title': 'Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)'} / Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) by Tomalia D. A. (1989)
(a)K.Rengan R.Engel J. Chem. Soc. Chem. Commun.1990 1084. (10.1039/c39900001084)
10.1039/p19910000987
{'issue': '3', 'key': 'e_1_2_1_11_4', 'first-page': '601', 'volume': '32', 'author': 'Engel R.', 'year': '1991', 'journal-title': 'Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)'} / Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) by Engel R. (1991)
10.1021/ja00281a038
10.1016/S0040-4020(01)87581-5
10.1021/ja00165a080
10.1016/S0040-4039(01)93876-6
10.1021/jo00251a010
10.1093/nar/18.13.3813
10.1021/ja00034a029
10.1002/anie.199214931
10.1007/BFb0111285
{'key': 'e_1_2_1_16_2', 'first-page': '357', 'volume-title': 'Applied Polymer Analysis and Characterization', 'author': 'Smith P. B.', 'year': '1987'} / Applied Polymer Analysis and Characterization by Smith P. B. (1987)
{'key': 'e_1_2_1_17_2', 'first-page': '46', 'volume-title': 'Encyclopedia of Polymer Science and Engineering', 'author': 'Tomalia D. A.', 'year': '1990'} / Encyclopedia of Polymer Science and Engineering by Tomalia D. A. (1990)
10.1002/adma.19920041116
10.1002/anie.199215711
{'key': 'e_1_2_1_20_2', 'first-page': '31', 'volume': '25', 'author': 'Newkome G. R.', 'year': '1992', 'journal-title': 'Aldrichimica Acta'} / Aldrichimica Acta by Newkome G. R. (1992)
10.1021/ja00177a027
10.1021/ja00011a031
(c)C. J.Hawker J. M. J.Fréchet J. Chem. Soc. Chem. Commun.1990 1010. (10.1039/C39900001010)
10.1021/cm00010a006
10.1021/cm00017a005
10.1002/rcm.1290050902
{'key': 'e_1_2_1_24_2', 'first-page': '52', 'volume': '34', 'author': 'Tomalia D. A.', 'year': '1993', 'journal-title': 'Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)'} / Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) by Tomalia D. A. (1993)
10.1021/ma00223a036
10.1039/p19910001059
10.1021/ja00059a004

Dates

Type	When
Created	20 years, 8 months ago (Dec. 29, 2004, 1 a.m.)
Deposited	2 years ago (Aug. 30, 2023, 11:37 p.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 1 a.m.)
Issued	31 years, 2 months ago (July 1, 1994)
Published	31 years, 2 months ago (July 1, 1994)
Published Online	20 years, 11 months ago (Sept. 15, 2004)
Published Print	31 years, 2 months ago (July 1, 1994)

Funders 0

None

BibTeX

@article{Tomalia_1994, title={Starburst/Cascade Dendrimers: Fundamental building blocks for a new nanoscopic chemistry set}, volume={6}, ISSN={1521-4095}, url={http://dx.doi.org/10.1002/adma.19940060703}, DOI={10.1002/adma.19940060703}, number={7–8}, journal={Advanced Materials}, publisher={Wiley}, author={Tomalia, Donald A.}, year={1994}, month=jul, pages={529–539} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T05:00:58Z",
    "timestamp": 1755925258871
  },
  "reference-count": 66,
  "publisher": "Wiley",
  "issue": "7-8",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            9,
            15
          ]
        ],
        "date-time": "2004-09-15T00:00:00Z",
        "timestamp": 1095206400000
      },
      "content-version": "vor",
      "delay-in-days": 3729,
      "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        7
      ]
    ]
  },
  "abstract": "<jats:p><jats:bold>That dendrimer structures act as fundamental chemical building blocks</jats:bold> (see Figure), forming a \u201cnanoscopic chemistry set\u201d analogous to the \u201cpicoscopic chemistry set\u201d formed by atoms, is discussed in this review. Following the logic used by 19th century chemists while defining the atomic \u201cchemistry set\u201d, it is shown that the ability to preface directionality in dendrimer systems validates this approach. <jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/must001.gif\"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>",
  "DOI": "10.1002/adma.19940060703",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        12,
        29
      ]
    ],
    "date-time": "2004-12-29T06:00:48Z",
    "timestamp": 1104300048000
  },
  "page": "529-539",
  "source": "Crossref",
  "is-referenced-by-count": 278,
  "title": "Starburst/Cascade Dendrimers: Fundamental building blocks for a new nanoscopic chemistry set",
  "prefix": "10.1002",
  "volume": "6",
  "author": [
    {
      "given": "Donald A.",
      "family": "Tomalia",
      "sequence": "first",
      "affiliation": []
    }
  ],
  "member": "311",
  "published-online": {
    "date-parts": [
      [
        2004,
        9,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_2_1_1_2",
      "unstructured": "Based on an invited lecture presented at the 33rd National Organic Chemistry Symposium (Bozeman MT; June 13\u201317 1993)."
    },
    {
      "key": "e_1_2_1_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1051/jphyslet:01983004409035100"
    },
    {
      "key": "e_1_2_1_3_2",
      "doi-asserted-by": "crossref",
      "unstructured": "E.Buhleier W.Wehner F.V\u00f6gtie Synthesis1978 155.",
      "DOI": "10.1055/s-1978-24702"
    },
    {
      "key": "e_1_2_1_4_2",
      "unstructured": "R. G.Denkewalter J. F.Kolc W. J.Lukasavage US Patent 4410688 1983;"
    },
    {
      "key": "e_1_2_1_4_3",
      "first-page": "103907",
      "volume": "100",
      "year": "1984",
      "journal-title": "Chem. Abstr."
    },
    {
      "key": "e_1_2_1_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jo00211a052"
    },
    {
      "key": "e_1_2_1_5_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00264a054"
    },
    {
      "key": "e_1_2_1_5_4",
      "doi-asserted-by": "crossref",
      "unstructured": "5cG. R.Newkome G. R.Baker M. J.Saunders P. S.Russo V. K.Gupta Z.\u2010Q.Yao J. E.Miller K.Bouillion J. Chem. Soc. Chem. Commun.1986 752.",
      "DOI": "10.1039/c39860000752"
    },
    {
      "key": "e_1_2_1_5_5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jo00056a023"
    },
    {
      "key": "e_1_2_1_6_2",
      "unstructured": "(a)D. A.Tomalia (August 1984) 1st Society Polymer Science Japan International Polym. Conf. Kyoto Japan; (See also reference [1])."
    },
    {
      "key": "e_1_2_1_6_3",
      "unstructured": "(b)D. A.Tomalia (19 March 1985) 6th Biennial CarlS.MarvelSymp. Tucson AZ USA."
    },
    {
      "key": "e_1_2_1_6_4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1295/polymj.17.117"
    },
    {
      "key": "e_1_2_1_6_5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ma00163a029"
    },
    {
      "key": "e_1_2_1_6_6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ma00171a051"
    },
    {
      "key": "e_1_2_1_6_7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jo00234a006"
    },
    {
      "key": "e_1_2_1_6_8",
      "unstructured": "(g)D. A.Tomalia J. R.Dewald US Patent 4 507 466 1985;"
    },
    {
      "key": "e_1_2_1_6_9",
      "unstructured": "US Patent 4 558 120 1985;"
    },
    {
      "key": "e_1_2_1_6_10",
      "unstructured": "US Patent 4 568 737 1986;"
    },
    {
      "key": "e_1_2_1_6_11",
      "unstructured": "US Patent 4 587 329 1986;"
    },
    {
      "key": "e_1_2_1_6_12",
      "unstructured": "US Patent 4 631 337 1986;"
    },
    {
      "key": "e_1_2_1_6_13",
      "unstructured": "US Patent 4 694 064 1987;"
    },
    {
      "key": "e_1_2_1_6_14",
      "unstructured": "US Patent 4 713 975 1987;"
    },
    {
      "key": "e_1_2_1_6_15",
      "unstructured": "US Patent 4 737 550 1988;"
    },
    {
      "key": "e_1_2_1_6_16",
      "unstructured": "US Patent 4 8711 779 1989;"
    },
    {
      "key": "e_1_2_1_6_17",
      "unstructured": "US Patent 4 857 599 1989."
    },
    {
      "key": "e_1_2_1_6_18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00239a068"
    },
    {
      "key": "e_1_2_1_6_19",
      "unstructured": "(i)D. A.Tomalia B\u00fcrgenstock Conf. May 3 1987 B\u00fcrgenstock Switzerland."
    },
    {
      "key": "e_1_2_1_6_20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/nadc.19870350704"
    },
    {
      "key": "e_1_2_1_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.199001381"
    },
    {
      "key": "e_1_2_1_7_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.199313061"
    },
    {
      "key": "e_1_2_1_7_4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.199313081"
    },
    {
      "key": "e_1_2_1_7_5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/cber.19931260925"
    },
    {
      "key": "e_1_2_1_8_2",
      "first-page": "115",
      "volume": "30",
      "author": "Wilson L. R.",
      "year": "1989",
      "journal-title": "Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)"
    },
    {
      "key": "e_1_2_1_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00175a062"
    },
    {
      "key": "e_1_2_1_9_3",
      "first-page": "182",
      "volume": "33",
      "author": "Roovers J.",
      "year": "1992",
      "journal-title": "Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)"
    },
    {
      "key": "e_1_2_1_9_4",
      "doi-asserted-by": "crossref",
      "unstructured": "(c)A. W.van der Made P. W. N. M.van Leeuwen J. Chem. Soc. Chem. Commun.1992 1400.",
      "DOI": "10.1039/c39920001400"
    },
    {
      "key": "e_1_2_1_9_5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/adma.19930050613"
    },
    {
      "key": "e_1_2_1_9_6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ma00057a013"
    },
    {
      "key": "e_1_2_1_10_2",
      "first-page": "119",
      "volume": "30",
      "author": "Tomalia D. A.",
      "year": "1989",
      "journal-title": "Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)"
    },
    {
      "key": "e_1_2_1_11_2",
      "doi-asserted-by": "crossref",
      "unstructured": "(a)K.Rengan R.Engel J. Chem. Soc. Chem. Commun.1990 1084.",
      "DOI": "10.1039/c39900001084"
    },
    {
      "key": "e_1_2_1_11_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/p19910000987"
    },
    {
      "issue": "3",
      "key": "e_1_2_1_11_4",
      "first-page": "601",
      "volume": "32",
      "author": "Engel R.",
      "year": "1991",
      "journal-title": "Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)"
    },
    {
      "key": "e_1_2_1_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00281a038"
    },
    {
      "key": "e_1_2_1_12_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0040-4020(01)87581-5"
    },
    {
      "key": "e_1_2_1_12_4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00165a080"
    },
    {
      "key": "e_1_2_1_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0040-4039(01)93876-6"
    },
    {
      "key": "e_1_2_1_13_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/jo00251a010"
    },
    {
      "key": "e_1_2_1_13_4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/18.13.3813"
    },
    {
      "key": "e_1_2_1_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00034a029"
    },
    {
      "key": "e_1_2_1_14_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.199214931"
    },
    {
      "key": "e_1_2_1_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BFb0111285"
    },
    {
      "key": "e_1_2_1_16_2",
      "first-page": "357",
      "volume-title": "Applied Polymer Analysis and Characterization",
      "author": "Smith P. B.",
      "year": "1987"
    },
    {
      "key": "e_1_2_1_17_2",
      "first-page": "46",
      "volume-title": "Encyclopedia of Polymer Science and Engineering",
      "author": "Tomalia D. A.",
      "year": "1990"
    },
    {
      "key": "e_1_2_1_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/adma.19920041116"
    },
    {
      "key": "e_1_2_1_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.199215711"
    },
    {
      "key": "e_1_2_1_20_2",
      "first-page": "31",
      "volume": "25",
      "author": "Newkome G. R.",
      "year": "1992",
      "journal-title": "Aldrichimica Acta"
    },
    {
      "key": "e_1_2_1_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00177a027"
    },
    {
      "key": "e_1_2_1_21_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00011a031"
    },
    {
      "key": "e_1_2_1_21_4",
      "doi-asserted-by": "crossref",
      "unstructured": "(c)C. J.Hawker J. M. J.Fr\u00e9chet J. Chem. Soc. Chem. Commun.1990 1010.",
      "DOI": "10.1039/C39900001010"
    },
    {
      "key": "e_1_2_1_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cm00010a006"
    },
    {
      "key": "e_1_2_1_22_3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/cm00017a005"
    },
    {
      "key": "e_1_2_1_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/rcm.1290050902"
    },
    {
      "key": "e_1_2_1_24_2",
      "first-page": "52",
      "volume": "34",
      "author": "Tomalia D. A.",
      "year": "1993",
      "journal-title": "Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.)"
    },
    {
      "key": "e_1_2_1_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ma00223a036"
    },
    {
      "key": "e_1_2_1_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1039/p19910001059"
    },
    {
      "key": "e_1_2_1_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/ja00059a004"
    }
  ],
  "container-title": "Advanced Materials",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fadma.19940060703",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.19940060703",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        8,
        31
      ]
    ],
    "date-time": "2023-08-31T03:37:14Z",
    "timestamp": 1693453034000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://onlinelibrary.wiley.com/doi/10.1002/adma.19940060703"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        7
      ]
    ]
  },
  "references-count": 66,
  "journal-issue": {
    "issue": "7-8",
    "published-print": {
      "date-parts": [
        [
          1994,
          7
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1002/adma.19940060703"
  ],
  "URL": "http://dx.doi.org/10.1002/adma.19940060703",
  "relation": {},
  "ISSN": [
    "0935-9648",
    "1521-4095"
  ],
  "subject": [],
  "container-title-short": "Advanced Materials",
  "published": {
    "date-parts": [
      [
        1994,
        7
      ]
    ]
  }
}