DOI: 10.1002/adfm.201102746. Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle‐Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch

Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle‐Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch

10.1002/adfm.201102746

Crossref journal-article

Wiley

Advanced Functional Materials (311)

Abstract

AbstractA novel approach for the fabrication of multifunctional microspheres integrating several advantages of mesoporous, luminescence, and temperature responses into one single entity is reported. First, the hollow mesoporous silica capsules are fabricated via a sacrificial template route. Then, Gd2O3:Eu3+ luminescent nanoparticles are incorporated into the internal cavities to form rattle‐type mesoporous silica nanocapsules by an incipient‐wetness impregnation method. Finally, the rattle‐type capsules serve as a nanoreactor for successfully filling temperature‐responsive hydrogel via photoinduced polymerization to form the multifunctional composite microspheres. The organic–inorganic hybrid microspheres show a red emission under UV irradiation due to the luminescent Gd2O3:Eu3+ core. The in vitro cytotoxicity tests show that the samples have good biocompatibility, which indicates that the nanocomposite could be a promising candidate for drug delivery. In addition, flow cytometry and confocal laser scanning microscopy (CLSM) confirm that the sample can be effectively taken up by SKOV3 cells. For in vitro magnetic resonance imaging (MRI), the sample shows the promising spin‐lattice relaxation time (T1) weighted effect and could potentially apply as a T1‐positive contrast agent. This composite drug delivery system (DDS) provides a positive temperature controlled “on‐off”drug release pattern and the drug, indomethacin (IMC), is released fast at 45 °C (on phase) and completely shut off at 20 °C (off phase). Meanwhile Gd2O3:Eu3+ plays an important role as the luminescent tag for tracking the drug loading and release process by the reversible luminescence quenching and recovery phenomenon. These results indicate that the obtained multifunctional composite has the potential to be used as a smart DDS for biomedical applications.

Bibliography

Kang, X., Cheng, Z., Yang, D., Ma, P., Shang, M., Peng, C., Dai, Y., & Lin, J. (2012). Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent RattleâType Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch. Advanced Functional Materials, 22(7), 1470â1481. Portico.

Authors 8

Xiaojiao Kang (first)
Ziyong Cheng (additional)
Dongmei Yang (additional)
Ping'an Ma (additional)
Mengmeng Shang (additional)
Chong Peng (additional)
Yunlu Dai (additional)
Jun Lin (additional)

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Dates

Type	When
Created	13 years, 7 months ago (Jan. 30, 2012, 10:58 a.m.)
Deposited	1 year, 10 months ago (Oct. 11, 2023, 1:21 p.m.)
Indexed	2 weeks, 3 days ago (Aug. 19, 2025, 7:11 a.m.)
Issued	13 years, 7 months ago (Jan. 30, 2012)
Published	13 years, 7 months ago (Jan. 30, 2012)
Published Online	13 years, 7 months ago (Jan. 30, 2012)
Published Print	13 years, 4 months ago (April 10, 2012)

Funders 0

None

BibTeX

@article{Kang_2012, title={Design and Synthesis of Multifunctional Drug Carriers Based on Luminescent Rattle‐Type Mesoporous Silica Microspheres with a Thermosensitive Hydrogel as a Controlled Switch}, volume={22}, ISSN={1616-3028}, url={http://dx.doi.org/10.1002/adfm.201102746}, DOI={10.1002/adfm.201102746}, number={7}, journal={Advanced Functional Materials}, publisher={Wiley}, author={Kang, Xiaojiao and Cheng, Ziyong and Yang, Dongmei and Ma, Ping’an and Shang, Mengmeng and Peng, Chong and Dai, Yunlu and Lin, Jun}, year={2012}, month=jan, pages={1470–1481} }

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