DOI: 10.1002/adfm.200901235. Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

10.1002/adfm.200901235

Crossref journal-article

Wiley

Advanced Functional Materials (311)

Abstract

AbstractIntegrating multiple functionalities into individual nanoscale complexes is of tremendous importance in biomedicine, expanding the capabilities of nanoscale structures to perform multiple parallel tasks. Here, the ability to enhance two different imaging technologies simultaneously—fluorescence optical imaging and magnetic resonance imaging—with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell‐based complex. The nanocomplexes are constructed by coating a gold nanoshell with a silica epilayer doped with Fe3O4 and the fluorophore ICG, which results in a high T2 relaxivity (390 mM−1 s−1) and 45× fluorescence enhancement of ICG. Bioconjugate nanocomplexes target HER2+ cells and induce photothermal cell death upon near‐IR illumination.

Bibliography

Bardhan, R., Chen, W., PerezâTorres, C., Bartels, M., Huschka, R. M., Zhao, L. L., Morosan, E., Pautler, R. G., Joshi, A., & Halas, N. J. (2009). Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response. Advanced Functional Materials, 19(24), 3901â3909. Portico.

Authors 10

Rizia Bardhan (first)
Wenxue Chen (additional)
Carlos Perez‐Torres (additional)
Marc Bartels (additional)
Ryan M. Huschka (additional)
Liang L. Zhao (additional)
Emilia Morosan (additional)
Robia G. Pautler (additional)
Amit Joshi (additional)
Naomi J. Halas (additional)

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Dates

Type	When
Created	15 years, 9 months ago (Nov. 17, 2009, 11:07 a.m.)
Deposited	1 year, 10 months ago (Oct. 10, 2023, 9:53 a.m.)
Indexed	1 week, 6 days ago (Aug. 23, 2025, 1:05 a.m.)
Issued	15 years, 8 months ago (Dec. 18, 2009)
Published	15 years, 8 months ago (Dec. 18, 2009)
Published Online	15 years, 8 months ago (Dec. 18, 2009)
Published Print	15 years, 8 months ago (Dec. 23, 2009)

Funders 0

None

BibTeX

@article{Bardhan_2009, title={Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response}, volume={19}, ISSN={1616-3028}, url={http://dx.doi.org/10.1002/adfm.200901235}, DOI={10.1002/adfm.200901235}, number={24}, journal={Advanced Functional Materials}, publisher={Wiley}, author={Bardhan, Rizia and Chen, Wenxue and Perez‐Torres, Carlos and Bartels, Marc and Huschka, Ryan M. and Zhao, Liang L. and Morosan, Emilia and Pautler, Robia G. and Joshi, Amit and Halas, Naomi J.}, year={2009}, month=dec, pages={3901–3909} }

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